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Computational modelling and Epidemiology

Section edited by Michael N. Liebman

This section aims to allow rapid communication of methods and results that utilize computational modeling and epidemiologic approaches in translational medicine. The focus will be on population-based studies that extend towards more molecular level analysis. 

Submission of studies involving methods development is encouraged where actual application and results can be shown in the healthcare and life sciences domains. Among the approaches highlighted in this section are data-mining for health impact, data modeling, health record system design, applications of epidemiologic analysis, public policy evaluation, hypothesis evaluation and testing, risk assessment in healthcare and life sciences. These articles will describe the perspective on translational medicine where the approach and results reflect the computational modeling and epidemiologic aspects of this emerging area of research.

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  1. Parkinson's disease (PD), the second most common neurodegenerative disease with notable clinical heterogeneity, has Parkinson disease dementia (PDD) that severely impacts patients' quality of life. As no effec...

    Authors: Tayier Tuersong, Yu Xuan Yong, Yan Chen, Pei Shan Li, Samire Shataer, Munire Shataer, Liang Ying Ma and Xin Ling Yang
    Citation: Journal of Translational Medicine 2025 23:535
  2. The brain imaging subtypes of schizophrenia have been widely investigated using data-driven approaches. However, the heterogeneity of SZ in multiple biological data is largely unknown.

    Authors: Yuran Wang, Shixuan Feng, Yuanyuan Huang, Runlin Peng, Liqin Liang, Wei Wang, Minxin Guo, Baoyuan Zhu, Heng Zhang, Jianhao Liao, Jing Zhou, Hehua Li, Xiaobo Li, Yuping Ning, Fengchun Wu and Kai Wu
    Citation: Journal of Translational Medicine 2025 23:505
  3. Per- and polyfluoroalkyl substances (PFAS), particularly perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), are synthetic chemicals known for their widespread use and environmental persistence...

    Authors: Yanggang Hong, Deqi Wang, Zeyu Liu, Yuxin Chen, Yi Wang and Jiajun Li
    Citation: Journal of Translational Medicine 2025 23:504
  4. Emerging evidence implicates environmental contaminants such as cadmium (Cd) as modifiable risk factors for anxiety. Despite growing recognition of heavy metal toxicity in neuropsychiatric disorders, the molec...

    Authors: Sheng Wan, Yong Yang, Qihan Zhao, Zelong Xing, Jie Li, Hao Gao, Yinghui Yin, Zhenzhong Liu, Qiwen Chen, Maoqin Tian, Xinxin Shi, Ziyue Ji and Shaoxin Huang
    Citation: Journal of Translational Medicine 2025 23:499
  5. Modifiable factors affect cancer’s survival but literature did not differentiate prior to versus after cancer diagnosis. It is essential to provide references for the intervention prioritized at different stages.

    Authors: Xiong Chen, Dongxi Zhu, Chenchen Li, Yi Lin, Lin Lv, Feiling Ai, Zhijian Chen, Runnan Shen, Xuwen Shen, Guochang You, Zhige Jiang, Wenlong Zhong and Tianxin Lin
    Citation: Journal of Translational Medicine 2025 23:486
  6. Early-life smoking is linked to biological aging and chronic diseases, yet its specific relationship with cardiovascular disease (CVD) risk and the role of DNA methylation biomarkers of aging as potential medi...

    Authors: Chang Sheng, Rui Zhou, Hongcai Wang, Guoqiang Lin, Zhou Cai and Wei Wang
    Citation: Journal of Translational Medicine 2025 23:484
  7. Metabolic Associated Steatotic Liver Disease (MASLD), encompassing conditions simple liver steatosis (MAFL) and metabolic associated steatohepatitis (MASH), is the most prevalent chronic liver disease. Current...

    Authors: Weiliang Zhang, Weirong Lu, Yaqi Jiao, Tianhao Li, Haining Wang and Chunhua Wan
    Citation: Journal of Translational Medicine 2025 23:472
  8. Epidemiological studies have found an association between air pollution and cardiovascular and cerebrovascular diseases (CACD) and its subtypes. However, there is a lack of individual-level data to explore the...

    Authors: Fei Lin, Guohua Li, Yongbin Wang, Pingshuan Dong, Kan Yang, Hui Liu, Na Xie, Jingyu Liu, Hengwen Chen, Xiaomei Liu, Huan Li, Xuefang Li, Dongxu Li, Siyu Sun, Xiulong Wang, Yujing Sun…
    Citation: Journal of Translational Medicine 2025 23:469
  9. Peripheral arterial disease (PAD) is a common cardiovascular disease that it is an important reason for the decline of patients’ quality of life and the increase of family economic burden. To systematically ev...

    Authors: Congzhi Yan, Jiahao Chen, Xinbing Xu, Hua Wei and Jinjiao Li
    Citation: Journal of Translational Medicine 2025 23:463
  10. Systems biology is a holistic approach to biological sciences that combines experimental and computational strategies, aimed at integrating information from different scales of biological processes to unravel ...

    Authors: Aurelia Morabito, Giulia De Simone, Roberta Pastorelli, Laura Brunelli and Manuela Ferrario
    Citation: Journal of Translational Medicine 2025 23:425
  11. Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health concern that necessitates early screening and timely intervention to improve prognosis. The current diagnostic protocols for ...

    Authors: Gangfeng Zhu, Yipeng Song, Zenghong Lu, Qiang Yi, Rui Xu, Yi Xie, Shi Geng, Na Yang, Liangjian Zheng, Xiaofei Feng, Rui Zhu, Xiangcai Wang, Li Huang and Yi Xiang
    Citation: Journal of Translational Medicine 2025 23:381
  12. Esophageal cancer (EC) presents a significant public health challenge globally, particularly in regions with high alcohol consumption. Its etiology is multifactorial, involving both genetic predispositions and...

    Authors: Oswald Ndi Nfor, Pei-Ming Huang, Ming-Fang Wu, Ke-Cheng Chen, Ying-Hsiang Chou, Mong-Wei Lin, Ji-Han Zhong, Shuenn-Wen Kuo, Yu-Kwang Lee, Chih-Hung Hsu, Jang-Ming Lee and Yung-Po Liaw
    Citation: Journal of Translational Medicine 2025 23:379
  13. Mind-body therapies are a group of treatments based on the theory of mind-body medicine, which are effective for a wide range of illnesses. However, there are no bibliometric papers that have examined the topi...

    Authors: Yunxiao Zhang, Wenwen Li, Sai Xu, Shudi Li, Zhen Hai Sun, Menghe Zhang, Yaoyao Zuo and Shouqiang Chen
    Citation: Journal of Translational Medicine 2025 23:365
  14. Understanding the evolving patterns of cardiovascular disease (CVD) burden attributable to ambient particulate matter pollution (APMP) is essential. Furthermore, research on the underlying mechanisms has mostl...

    Authors: Haoxian Tang, Jingtao Huang, Hanyuan Lin, Xuan Zhang, Qinglong Yang, Nan Luo, Mengyue Lin, Cuihong Tian, Shiwan Wu, Jianan Hong, Jiasheng Wen, Liwen Jiang, Pan Chen, Xiaojing Chen, Junshuang Tang, Youti Zhang…
    Citation: Journal of Translational Medicine 2025 23:359
  15. The number of cancer survivors has steadily increased due to earlier detection and more effective therapies. Do all types of cancer survivors have an increased risk of developing subsequent cancers compared wi...

    Authors: Yubo Wang, Yining Jiang, Yang Bai and Haiyang Xu
    Citation: Journal of Translational Medicine 2025 23:355
  16. As global cancer incidence and mortality rise, digital twin technology in precision medicine offers new opportunities for cancer treatment.

    Authors: Shiying Shen, Wenhao Qi, Xin Liu, Jianwen Zeng, Sixie Li, Xiaohong Zhu, Chaoqun Dong, Bin Wang, Yankai Shi, Jiani Yao, Bingsheng Wang, Louxia Jing, Shihua Cao and Guanmian Liang
    Citation: Journal of Translational Medicine 2025 23:348
  17. Lung cancer, one of the leading causes of cancer-related morbidity and mortality worldwide, is strongly associated with smoking as its primary carcinogenic factor. However, despite the strong link between smok...

    Authors: Can Ouyang, Xiaopeng Yu, Huazhong Wang and Puhua Zeng
    Citation: Journal of Translational Medicine 2025 23:330
  18. Advancements in artificial intelligence (AI) and machine learning (ML) have revolutionized the medical field and transformed translational medicine. These technologies enable more accurate disease trajectory m...

    Authors: Laith Abualigah, Saleh Ali Alomari, Mohammad H. Almomani, Raed Abu Zitar, Kashif Saleem, Hazem Migdady, Vaclav Snasel, Aseel Smerat and Absalom E. Ezugwu
    Citation: Journal of Translational Medicine 2025 23:302
  19. Postpartum depression (PPD) is a significant public health issue. This study aimed to develop and validate machine learning (ML) models using biopsychosocial predictors to predict the risk of PPD for perinatal...

    Authors: Weijing Qi, Yongjian Wang, Yipeng Wang, Sha Huang, Cong Li, Haoyu Jin, Jinfan Zuo, Xuefei Cui, Ziqi Wei, Qing Guo and Jie Hu
    Citation: Journal of Translational Medicine 2025 23:291
  20. Studies have indicated that COVID-19 infection may accelerate the aging process in organisms. However, it remains unknown whether contracting COVID-19 affects life expectancy. Furthermore, the underlying biolo...

    Authors: Shizheng Qiu, Jianhua Liu, Jiahe Guo, Zhishuai Zhang, Yu Guo and Yang Hu
    Citation: Journal of Translational Medicine 2025 23:283
  21. Alzheimer’s disease (AD) is the main cause of dementia with few effective therapies. We aimed to identify potential plasma biomarkers or drug targets for AD by investigating the causal association between plas...

    Authors: Hui Zhan, Davis Cammann, Jeffrey L. Cummings, Xianjun Dong and Jingchun Chen
    Citation: Journal of Translational Medicine 2025 23:278
  22. Osteonecrosis (ON) is a debilitating orthopedic condition characterized by bone cell death due to impaired blood supply, leading to structural changes and disability. Osteoporosis (OP), a systemic skeletal dis...

    Authors: Chao Zhang, Hao Yu, Yulin Miao and Biaofang Wei
    Citation: Journal of Translational Medicine 2025 23:226
  23. Given the close relationship between lipids and gestational diabetes mellitus(GDM), the present study sought to examine the association between the triglyceride high-density cholesterol-glucose body index(TyHG...

    Authors: Ziyi Xu, Changhui Li, Nanzhu Wang and Guojiao Song
    Citation: Journal of Translational Medicine 2025 23:190
  24. The aim of this study was to explore the systemic inflammation response in relation to mortality in Helicobacter pylori (H. pylori) infection, and whether this relationship was mediated by accelerated biological ...

    Authors: Jiayu Qiu, Hui Fang, Dingwei Liu, Qirui Lai, Jinliang Xie, Youhua Wang, Sihai Chen and Yong Xie
    Citation: Journal of Translational Medicine 2025 23:174
  25. Methylglyoxal (MGO)-induced cell death in vascular endothelial cells (VECs) plays a critical role in the progression of diabetic vascular complications (DVCs). Previous studies have shown that MGO can induce i...

    Authors: Ruqiang Yuan, Hu Xu, Mingqi Wang, Lina Guo, Yang Yao, Xiaoru Zhang and Xiuli Wang
    Citation: Journal of Translational Medicine 2025 23:170
  26. Heart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and an...

    Authors: Beiqin Liu, Shuyue Wang, Hong Ma, Yulin Deng, Jichen Du, Yimeng Zhao and Yu Chen
    Citation: Journal of Translational Medicine 2025 23:132
  27. To develop a machine learning-based prediction model using clinical data from the first 24 h of ICU admission to enable rapid screening and early intervention for sepsis patients.

    Authors: Songchang Shi, Lihui Zhang, Shujuan Zhang, Jinyang Shi, Donghuang Hong, Siqi Wu, Xiaobin Pan and Wei Lin
    Citation: Journal of Translational Medicine 2025 23:97
  28. Risk-based breast cancer screening offers a more targeted and potentially cost-effective approach in cancer detection compared to age-based screening. This study aims to understand women’s preferences and will...

    Authors: Yi Wang, Peh Joo Ho, Langming Mou and Jingmei Li
    Citation: Journal of Translational Medicine 2025 23:96
  29. Despite the use of Next-Generation Sequencing (NGS) as the gold standard for the diagnosis of rare diseases, its clinical implementation has been challenging, limiting the cost-effectiveness of NGS and the und...

    Authors: Cristina Méndez-Vidal, Nereida Bravo-Gil, Javier Pérez-Florido, Irene Marcos-Luque, Raquel M. Fernández, José Luis Fernández-Rueda, María González-del Pozo, Marta Martín-Sánchez, Elena Fernández-Suárez, Marcela Mena, Rosario Carmona, Joaquín Dopazo, Salud Borrego and Guillermo Antiñolo
    Citation: Journal of Translational Medicine 2025 23:86
  30. Acute respiratory distress syndrome (ARDS) is a prevalent complication among critically ill patients, constituting around 10% of intensive care unit (ICU) admissions and mortality rates ranging from 35 to 46%....

    Authors: Senhao Wei, Hua Zhang, Hao Li, Chao Li, Ziyuan Shen, Yiyuan Yin, Zhukai Cong, Zhaojin Zeng, Qinggang Ge, Dongfeng Li and Xi Zhu
    Citation: Journal of Translational Medicine 2025 23:64
  31. Mounting evidence suggests that Parkinson’s disease (PD) and inflammatory bowel disease (IBD) are closely associated and becoming global health burdens. However, the causal relationships and common pathogenese...

    Authors: Beiming Wang, Xiaoyin Bai, Yingmai Yang and Hong Yang
    Citation: Journal of Translational Medicine 2025 23:45
  32. This study aims to develop a novel risk assessment tool for coronary artery disease (CAD) based on data of patients with chest pain in outpatient and emergency department, thereby facilitating the effective id...

    Authors: Zu-Fei Wu, Si-Xiao Tao, Wen-Tao Su, Shi Chen, Bai-Da Xu, Gang-Jun Zong and Gang-Yong Wu
    Citation: Journal of Translational Medicine 2025 23:41
  33. Artificial sweeteners (AS) have been widely utilized in the food, beverage, and pharmaceutical industries for decades. While numerous publications have suggested a potential link between AS and diseases, parti...

    Authors: Jumin Xie, Ying Zhu, Zixuan Yang, Zhang Yu, Mingzhi Yang and Qingzhi Wang
    Citation: Journal of Translational Medicine 2025 23:32
  34. Recent studies suggest a connection between immunoglobulin light chains (IgLCs) and coronary heart disease (CHD). However, current diagnostic methods using peripheral blood IgLCs levels or subtype ratios show ...

    Authors: Wenbo Ren, Zichen Zhang, Yifei Wang, Jiangyuan Wang, Li Li, Lin Shi, Taiyu Zhai and Jing Huang
    Citation: Journal of Translational Medicine 2025 23:22
  35. Animal systematic reviews are critical to inform translational research. Despite their growing popularity, there is a notable lack of information on their quality, scope, and geographical distribution over tim...

    Authors: Bernard Friedrich Hild, David Brüschweiler, Sophia Theodora Katharina Hild, Julia Bugajska, Viktor von Wyl, Marianna Rosso, Kimberley Elaine Wever, Eva Furrer and Benjamin Victor Ineichen
    Citation: Journal of Translational Medicine 2025 23:21
  36. Cardiac arrest (CA), characterized by its heterogeneity, poses challenges in patient management. This study aimed to identify clinical subphenotypes in CA patients to aid in patient classification, prognosis a...

    Authors: Weidong Zhang, Chenxi Wu, Peifeng Ni, Sheng Zhang, Hongwei Zhang, Ying Zhu, Wei Hu and Mengyuan Diao
    Citation: Journal of Translational Medicine 2025 23:16
  37. Heavy metal exposure is an emerging environmental risk factor linked to cardiovascular disease (CVD) through its effects on vascular ageing. However, the relationship between heavy metal exposure and vascular ...

    Authors: Yuntao Feng, Chengxing Liu, Litang Huang, Jun Qian, Na Li, Hongwei Tan and Xuebo Liu
    Citation: Journal of Translational Medicine 2025 23:4
  38. The relationship between cigarette smoking and diabetic retinopathy (DR) remains controversial, as existing studies have yielded inconsistent results. This study aimed to investigate the association between sm...

    Authors: Bin Wang, Hui Li, Huafeng Ma and ZaiHong Chen
    Citation: Journal of Translational Medicine 2024 22:1169
  39. It is unclear regarding the association between metabolomic state/genetic risk score(GRS) and brain volumes and how much of variance of brain volumes is attributable to metabolomic state or GRS.

    Authors: Xueli Zhang, Yu Huang, Shunming Liu, Shuo Ma, Min Li, Zhuoting Zhu, Wei Wang, Xiayin Zhang, Jiahao Liu, Shulin Tang, Yijun Hu, Zongyuan Ge, Honghua Yu, Mingguang He and Xianwen Shang
    Citation: Journal of Translational Medicine 2024 22:1098
  40. Although research has indicated correlations between lipids, cerebrospinal fluid (CSF) metabolites, and Late-Onset Alzheimer’s Disease (LOAD), the specific causal relationships among these elements, as well as...

    Authors: Jie Jie, Yonglu Gong, Hongbo Hu and Su Liu
    Citation: Journal of Translational Medicine 2024 22:1077
  41. The global outbreak of the coronavirus disease 2019 (COVID-19) has been enormously damaging, in which prolonged shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously 2019-nCoV) in...

    Authors: Yani Zhang, Qiankun Li, Haijun Duan, Liang Tan, Ying Cao and Junxin Chen
    Citation: Journal of Translational Medicine 2024 22:1054
  42. Benign prostatic hyperplasia (BPH) is a common chronic condition in elderly men. Observational studies have identified several comorbidities associated with BPH. However, these studies are limited by various c...

    Authors: Zhenfeng Song, Zhangkai J. Cheng, Hong Yuan, Zhenglin Chang, Yifan Lv, Xianbin Huang, Haiyang Li, Zhiman Liang, WenHan Cao, YouPeng Chen, HaoJie Wu, Defeng Qi and Baoqing Sun
    Citation: Journal of Translational Medicine 2024 22:1035
  43. Gut microbiome plays a significant role in longevity, and dysbiosis is indeed one of the hallmarks of aging. However, the causal relationship between gut microbiota and human longevity or aging remains elusive.

    Authors: Shu Chen, Wei Chen, Xudong Wang and Sheng Liu
    Citation: Journal of Translational Medicine 2024 22:1032
  44. Inflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder, and its incidence of comorbid with major depressive disorder (MDD) is significantly higher than the general population. How...

    Authors: Chaoqun Hu, Mei Ge, Yan Liu, Wei Tan, Yingzhi Zhang, Min Zou, Lingya Xiang, Xiaomei Song and Hong Guo
    Citation: Journal of Translational Medicine 2024 22:997
  45. Cardiac arrest presents a variety of causes and complexities, making it challenging to develop targeted treatment plans. Often, the original data are either inadequate or lack essential patient information. In...

    Authors: Yan Shao, Zhou Yang, Wei Chen and Yingqi Zhang
    Citation: Journal of Translational Medicine 2024 22:996
  46. There is evidence that inflammatory arthritis in the form of ankylosing spondylitis (AS), psoriatic arthritis (PsA), and rheumatoid arthritis are both positively and negatively associated with certain female-s...

    Authors: Christa Meisinger, Simone Fischer, Tracy O’Mara and Dennis Freuer
    Citation: Journal of Translational Medicine 2024 22:962
  47. Disorders of consciousness (DoC) are a group of conditions that affect the level of awareness and communication in patients. While neuroimaging techniques can provide useful information about the brain structu...

    Authors: Zengxin Qi, Wenwen Zeng, Di Zang, Zhe Wang, Lanqin Luo, Xuehai Wu, Jinhua Yu and Ying Mao
    Citation: Journal of Translational Medicine 2024 22:950

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