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Cellular Metabolism Therapy

Section Edited by Salvatore Nesci

Cellular Metabolism Therapy aims to promote the translation of basic research emerging from biochemistry, molecular medicine, physiology and biotechnology into cell metabolism in order to be exploited in clinical applications. 

Studies considered for publication will cover any aspect of translational metabolic research, including (but not limited to): genetic disorders and epigenetic diseases; metabolic derangements causing neurodegeneration; immunometabolism; stroke; cardiovascular diseases; tumours; stem cell bioenergetics; ageing; carbohydrate, lipid, and protein metabolism.


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  1. T-cell acute lymphoblastic leukemia (T-ALL) is a relatively rare hematological malignancy, characterized by the uncontrolled proliferation of immature T lymphoblasts and associated with a generally unfavorable...

    Authors: Shanshan Guo, Ekaterina Bourova-Flin, Sophie Rousseaux, Florent Chuffart, Lijun Peng, Duohui Jing, Jian-Qing Mi, Saadi Khochbin and Jin Wang
    Citation: Journal of Translational Medicine 2025 23:542
    Content type: Research Published on:

  2. As a research hotspot in the field of regenerative medicine, hepatocyte regeneration has great potential in the treatment of liver diseases. This paper comprehensively summarizes the diverse sources of hepatoc...

    Authors: Xiaoyi Zhang, Shenghao Li, Liyuan Hao, Fukang Jia, Fei Yu and Xiaoyu Hu
    Citation: Journal of Translational Medicine 2025 23:493
    Content type: Review Published on:

  3. Autosomal dominant optic atrophy (ADOA), a leading common inherited optic neuropathy, arises from progressive retinal ganglion cell degeneration, often linked to OPA1 mutations. OPA1, a mitochondrial GTPase, r...

    Authors: Kexuan Zhang, Wenqing Zhang, Lin Zhang, Xiaorong Hou, Runyi Tian, Zhengmao Hu, Lili Yin and Zhonghua Hu
    Citation: Journal of Translational Medicine 2025 23:471
    Content type: Research Published on:

  4. Colorectal cancer (CRC) is the leading cause for cancer mortality across the world. GRPEL2 is a critical regulator of mitochondria’s function with an oncogenic role in different kinds of cancer. The exact func...

    Authors: Cheng Song, Lei Zhao, Jing Deng, Li Wang, Min Mao, Siyuan Peng and Wei Tang
    Citation: Journal of Translational Medicine 2025 23:466
    Content type: Research Published on:

  7. Exposomes are critical drivers of carcinogenesis. However, how they modulate tumor behavior remains unclear. Extensive clinical data show cigarette smoke to be a key exposome that promotes aggressive tumors, h...

    Authors: Yang Li, Pedram Yadollahi, Fonma N. Essien, Vasanta Putluri, Chandra Shekar R. Ambati, Karthik Reddy Kami Reddy, Abu Hena Mostafa Kamal, Nagireddy Putluri, Lama M. Abdurrahman, Maria E. Ruiz Echartea, Keenan J. Ernste, Akshar J. Trivedi, Jonathan Vazquez-Perez, William H. Hudson, William K. Decker, Rutulkumar Patel…
    Citation: Journal of Translational Medicine 2025 23:403
    Content type: Research Published on:

  8. The transcription factor SRY-related HMG-box 4 (SOX4) has been implicated in intervertebral disc diseases. This study aimed to investigate the role of SOX4 in intervertebral disc degeneration (IDD) and explore...

    Authors: Wenzhi Zhao, Yadong Liu, Yunxiang Hu and Guiqi Zhang
    Citation: Journal of Translational Medicine 2025 23:395
    Content type: Research Published on:

  9. Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, with a prevalence as high as 32.4%. MASLD encompasses a spectrum of liver pathologies, rangi...

    Authors: Yu Zhang, Jiahui Yang, Jiali Min, Shan Huang, Yuchen Li and Shanshan Liu
    Citation: Journal of Translational Medicine 2025 23:368
    Content type: Review Published on:

  10. Glioma stem cells (GSCs) exhibit significant resistance to conventional radiotherapy and chemotherapy, contributing to high recurrence rates in gliomas. Addressing this critical clinical need, we developed DMC...

    Authors: Lei Shi, Xifeng Fei, Jian Huang, Bao He, Zhixiang Sun and Guan Sun
    Citation: Journal of Translational Medicine 2025 23:363
    Content type: Research Published on:

  11. Gastric cancer (GC) is one of the most common malignancies. Previous studies have shown that mitochondrial metabolism is associated with malignancies. However, relevant research on mitochondria-related lncRNAs...

    Authors: Shanshan Yu, Jinxiao Liang, Lixiao Liu, Ming Chen, Cheng Chen and Donghui Zhou
    Citation: Journal of Translational Medicine 2025 23:290
    Content type: Research Published on:

  12. Among all malignancies, colorectal cancer ranks third in incidence rate and second in mortality rate. Human beta-defensin-1 (hBD-1) has broad-spectrum antimicrobial properties, and it plays an important role i...

    Authors: Shixiang An, Jiaxian Cui, Wenhong Yang, Mingyu Zhang, Huiling Yu, Jingkun Lu, Yunpeng Tian, Lu Qiao, Xiumei Wang, Lili Bao and Pengwei Zhao
    Citation: Journal of Translational Medicine 2025 23:281
    Content type: Research Published on:

  13. Lipopolysaccharide (LPS) is known to induce cell injury and mitochondrial dysfunction, which are pivotal in neuroinflammation and related disorders. Recent studies have demonstrated the potential of nicotinami...

    Authors: Jia Li, Xiao-Yu Cheng, Rui-Xia Ma, Bin Zou, Yue Zhang, Miao-Miao Wu, Yao Yao and Juan Li
    Citation: Journal of Translational Medicine 2025 23:279
    Content type: Research Published on:

  14. Myocardial ischemia has the highest disease burden among all cardiovascular diseases making it a significant challenge to the global public health. It can result in myocardial cell damage and death due to impa...

    Authors: Chen Chen, Guohua Dai, Maoxia Fan, Xingmeng Wang, Kaibin Niu and Wulin Gao
    Citation: Journal of Translational Medicine 2025 23:277
    Content type: Review Published on:

  15. MCT4 is a lactate transporter associated with glycolysis, which has been found to be associated with various tumorigenesis and development processes. Gastric cancer is a malignant disease with high incidence a...

    Authors: Tao Jiang, Jingcheng Zhang, Sicheng Zhao, Mingsi Zhang, Yunhai Wei, Xiaojuan Liu, Shuo Zhang, Wei Fan, Yueying Liu, Yuanlin Lv and Guangji Zhang
    Citation: Journal of Translational Medicine 2025 23:276
    Content type: Research Published on:

  16. Microvascular complications of diabetes pose a significant threat to global health, mainly including diabetic kidney disease (DKD), diabetic retinopathy (DR), diabetic peripheral neuropathy (DPN), and diabetic...

    Authors: Xiangjie Hu, Jiao Lv, Yunyun Zhao, Xiangyan Li, Wenxiu Qi and Xiuge Wang
    Citation: Journal of Translational Medicine 2025 23:269
    Content type: Review Published on:

  17. Cellular senescence is a state of irreversible cell growth arrest. As such, senescence induction is viewed as an efficacious countermeasure in cancer treatment. Flap endonuclease 1 (FEN1) has been reported to ...

    Authors: Min Wu, Benmeng Wu, Xiaoshan Huang, Zirui Wang, Miaolin Zhu, Yaqin Zhu, Lin Yu and Jingjing Liu
    Citation: Journal of Translational Medicine 2025 23:248
    Content type: Research Published on:

  18. Ovarian aging has become a focal point in current research on female aging and refers to the gradual decline in ovarian function as women age. Numerous factors influence ovarian aging, among which mitochondria...

    Authors: Xiaoyue Zhang, Ling Zhang and Wenpei Xiang
    Citation: Journal of Translational Medicine 2025 23:211
    Content type: Review Published on:

  19. Cystinosis is a rare, incurable lysosomal storage disease caused by mutations in the CTNS gene encoding the cystine transporter cystinosin, which leads to lysosomal cystine accumulation in all cells of the body. ...

    Authors: Sante Princiero Berlingerio, Tjessa Bondue, Sarah Tassinari, Florian Siegerist, Angela Ferrulli, Celien Lismont, Sara Cairoli, Bianca Maria Goffredo, Bart Ghesquière, Marc Fransen, Nicole Endlich, Fanny Oliveira Arcolino, Benedetta Bussolati, Lambertus van den Heuvel and Elena Levtchenko
    Citation: Journal of Translational Medicine 2025 23:206
    Content type: Research Published on:

  20. Pulmonary fibrosis (PF) severely impacts both the survival and quality of life of patients with acute respiratory distress syndrome (ARDS) and remains a leading cause of late-stage ARDS-related mortality. The ...

    Authors: Jinhua Feng, Xi Huang, Yawen Peng, Wenyu Yang, Xinyi Yang, Ri Tang, Qiaoyi Xu, Yuan Gao, Zhengyu He, Shunpeng Xing and Shuya Mei
    Citation: Journal of Translational Medicine 2025 23:205
    Content type: Research Published on:

  21. Sepsis is a potentially fatal condition with a significant risk of death. Acute lung injury (ALI) is a life-threatening complication of sepsis, and the inflammatory response plays a critical role in sepsis-ind...

    Authors: Wenhan Li, Yuhan Li, Linjie Xiao, Zhanzhan Xie, Jun Peng, Wenhui Huang, Xu Li and Ying Meng
    Citation: Journal of Translational Medicine 2025 23:181
    Content type: Research Published on:

  22. Approximately half of patients with chronic ischemic cerebrovascular disease (CICD) exhibit poor revascularization. Metallothionein 2 A (MT2A) has a high affinity for metal ions and is potentially capable of c...

    Authors: Ni Mo, Chuyang Tai, Yang Yang, Cong Ling, Baoyu Zhang, Lei Wei, Cian Yao, Hui Wang and Chuan Chen
    Citation: Journal of Translational Medicine 2025 23:162
    Content type: Research Published on:

  23. The immune evasion and prolonged survival of Staphylococcus aureus (S. aureus) within macrophages are key factors contributing to the difficulty in curing osteomyelitis. Although macrophages play a vital role as ...

    Authors: Yaji Yang, Haotian Zhou, Feilong Li, Yanhao Zhang, Jianye Yang, Yidong Shen, Ning Hu, Quanming Zou, Leilei Qin, Hao Zeng and Wei Huang
    Citation: Journal of Translational Medicine 2025 23:156
    Content type: Research Published on:

  24. Drug resistance constitutes one of the principal causes of poor prognosis in breast cancer patients. Although cancer cells can maintain viability independently of mitochondrial energy metabolism, they remain r...

    Authors: Tiankai Xu, Chu Chu, Shuyu Xue, Tongchao Jiang, Ying Wang, Wen Xia and Huanxin Lin
    Citation: Journal of Translational Medicine 2025 23:131
    Content type: Research Published on:

  25. In patients with acute myocardial infarction (AMI), thrombolytic therapy and revascularization strategies allow complete recanalization of occluded epicardial coronary arteries. However, approximately 35% of p...

    Authors: Kaixin Wang, Qing Zhu, Wen Liu, Linyuan Wang, Xinxin Li, Cuiting Zhao, Nan Wu and Chunyan Ma
    Citation: Journal of Translational Medicine 2025 23:125
    Content type: Review Published on:

  26. The endoplasmic reticulum (ER) is a vital organelle responsible for protein quality control, including the folding, modification, and transport of proteins. When misfolded or unfolded proteins accumulate in th...

    Authors: Jiao Lv, Honghai Yu, Sasa Du, Pengyu Xu, Yunyun Zhao, Wenxiu Qi and Xiuge Wang
    Citation: Journal of Translational Medicine 2025 23:95
    Content type: Review Published on:

  27. Mitochondria are crucial to the function of renal tubular cells, and their dynamic perturbation in many aspects is an important mechanism of diabetic kidney disease (DKD). Single-nucleus RNA sequencing (snRNA-...

    Authors: Zhen Zhu, Guangxin Luan, Song Wu, Yiyi Song, Shuang Shen, Kaiyue Wu, Shengnan Qian, Weiping Jia, Jun Yin, Tao Ren, Jianping Ye and Li Wei
    Citation: Journal of Translational Medicine 2025 23:90
    Content type: Research Published on:

  28. Sepsis is a systemic inflammatory syndrome that can cause coagulation abnormalities, leading to damage in multiple organs. Vascular endothelial cells (VECs) are crucial in the development of sepsis-induced coa...

    Authors: Jun Zhang, Xing Zhu, Yong Li, Yinyu Wu, Yunxia Du, Hai Yang, Zhengchao Liu, Haoyu Pei, Rui Li, Huan Luo, Deyu Zuo, Han She and Qingxiang Mao
    Citation: Journal of Translational Medicine 2025 23:80
    Content type: Research Published on:

  29. Chronic liver diseases are highly linked with mitochondrial dysfunction and macrophage infiltration. Mallory-Denk bodies (MDBs) are protein aggregates associated with hepatic inflammation, and MDBs pathogenesi...

    Authors: Zixuan Fang, Bei Zhong, Yi Shi, Wanmei Zhou, Maoping Huang, Samuel W. French, Xiaoping Tang and Hui Liu
    Citation: Journal of Translational Medicine 2025 23:77
    Content type: Research Published on:

  30. With breast cancer being the most common tumor among women in the world today, it is also the leading cause of cancer-related deaths. Standard treatments include chemotherapy, surgery, endocrine therapy, and t...

    Authors: Aoling Huang, Haochen Xue, Ting Xie, Lingyan Xiang, Zhengzhuo Chen, Aolong Ma, Honglin Yan and Jingping Yuan
    Citation: Journal of Translational Medicine 2025 23:70
    Content type: Review Published on:

  31. Pharmacological vitamin C (Vit-C), or high-dose Vit-C has recently gained attention as a potential cancer therapeutic. However, the anticancer activity of Vit-C has not been investigated in realistic 3D models...

    Authors: Ali Mussa, Mahasin Hamid, Khalid Hajissa, Ahmad Hafiz Murtadha, Mohammad A. I. Al-Hatamleh, Noor Fatmawati Mokhtar, Vuk Uskoković, Magdalena Plebanski, Rohimah Mohamud and Rosline Hassan
    Citation: Journal of Translational Medicine 2025 23:31
    Content type: Research Published on:

  32. Skeletal muscle injury caused by excessive exercise is one of the most commonly seen clinical diseases. It is indispensable to explore drugs for treating and relieving skeletal muscle injury. Gallic acid (GA) ...

    Authors: Likai Yu, Di Tian, Zishan Su, Li Zhang, Shaobo Guo, Wenhui Zhu, Yuan Fang, Peimin Wang and Nongshan Zhang
    Citation: Journal of Translational Medicine 2025 23:30
    Content type: Research Published on:

  33. The inflammatory responses from synovial fibroblasts and macrophages and the mitochondrial dysfunction in chondrocytes lead to oxidative stress, disrupt extracellular matrix (ECM) homeostasis, and accelerate t...

    Authors: Ana Maria Vega-Letter, Cynthia García-Guerrero, Liliana Yantén-Fuentes, Carolina Pradenas, Yeimi Herrera-Luna, Eliana Lara-Barba, Felipe A. Bustamante-Barrientos, Masyelly Rojas, María Jesús Araya, Nicole Jeraldo, Constanza Aros, Francisca Troncoso, Daniela Poblete, Angela Court, Alexander Ortloff, Jose Barraza…
    Citation: Journal of Translational Medicine 2025 23:26
    Content type: Research Published on:

  34. Coronary artery disease (CAD) has become a dominant economic and health burden worldwide, and the role of autophagy in CAD requires further clarification. In this study, we comprehensively revealed the associa...

    Authors: Yanjun Wang, Xin Zhang, Mengmeng Ren, Shu He, Hengjie Bie, Mengyang Duan, Zhiyuan Chen, Qiaowei Jia, Boyu Chi, Xiongkang Gan, Chengcheng Li, Yahong Fu, Hanxiao Zhou, Sheng Zhang, Qian Zhang, Fenghui An…
    Citation: Journal of Translational Medicine 2024 22:1171
    Content type: Research Published on:

  35. Cardiovascular diseases (CVDs) are the leading cause of mortality among individuals with noncommunicable diseases worldwide. Obesity is associated with an increased risk of developing cardiovascular disease (C...

    Authors: Baile Zuo, Xiaoyan Li, Dawei Xu, Liping Zhao, Yang Yang, Yi Luan and Bi Zhang
    Citation: Journal of Translational Medicine 2024 22:1160
    Content type: Review Published on:

  36. Increased ribosome biogenesis is required for tumor growth. In this study, we investigated the function and underlying molecular mechanism of ribosome biogenesis factor (RBIS) in the progression of non-small c...

    Authors: Hongyu Pan, Li Liao, Siwei Xu, Yujian Xu, Wenjun Chai, Xiaoli Liu, Jing Li, Yue Cao, Lei Sun, Qian Liu and Mingxia Yan
    Citation: Journal of Translational Medicine 2024 22:1147
    Content type: Research Published on:

  37. Stem cells derived from the apical papilla (SCAPs) play a crucial role in tooth root development and dental pulp regeneration. They are important seed cells for bone/tooth tissue engineering. However, replicat...

    Authors: Yijia Shi, Tong Xiao, Yingying Weng, Ya Xiao, Jintao Wu, Jing Wang, Wenmin Wang, Maoshen Yan, Ming Yan, Zehan Li and Jinhua Yu
    Citation: Journal of Translational Medicine 2024 22:1129
    Content type: Research Published on:

  38. Ulcerative colitis (UC) is a persistent inflammatory bowels disease (IBD) characterized by immune response dysregulation and metabolic disruptions. Tryptophan metabolism has been believed as a significant fact...

    Authors: Guorong Chen, Hongying Qi, Li Jiang, Shijie Sun, Junhai Zhang, Jiali Yu, Fang Liu, Yanli Zhang and Shiyu Du
    Citation: Journal of Translational Medicine 2024 22:1121
    Content type: Research Published on:

  39. Yes-associated protein 1 (YAP1) regulates the survival, proliferation, and stemness of cells, and contributes to the development of metabolic dysfunction associated fatty liver disease (MAFLD). However, the re...

    Authors: Tiancheng Mao, Xianjun Xu, Leheng Liu, Yulun Wu, Xiaowan Wu, Wenlu Niu, Dandan You, Xiaobo Cai, Lungen Lu and Hui Zhou
    Citation: Journal of Translational Medicine 2024 22:1119
    Content type: Research Published on:

  40. Dietary cholesterol promotes metabolic dysfunction-associated steatohepatitis (MASH), with hepatic macrophages central to disease pathology. However, the mechanisms by which cholesterol-loaded macrophages infl...

    Authors: Xiaoxiao Li, Kai Wang, Yunhong Sun, Yirong Wang, Jiaxuan Wu, Yanqi Dang, Meng Li and Wenjun Zhou
    Citation: Journal of Translational Medicine 2024 22:1085
    Content type: Research Published on:

  41. Excessive oxidative stress is known to cause endothelial dysfunction and drive cardiovascular diseases (CVD). While telomerase reverse transcriptase (TERT) shows protective effects against oxidative stress in ...

    Authors: Haijing Zhao, Nian Cao, Qi Liu, Yingyue Zhang, Rui Jin, Huiying Lai, Li Zheng, Honghong Zhang, Yue Zhu, Yuhan Ma, Zengao Yang, Zhengfeng Wu, Weini Li, Yuqi Liu, Long Cheng and Yundai Chen
    Citation: Journal of Translational Medicine 2024 22:1080
    Content type: Research Published on:

  42. Intervertebral disc degeneration (IVDD) is a common cause of low back pain. Procyanidin C1 (PCC1) has been demonstrated to exert a protective effect on nucleus pulposus (NP) cells, and therefore, plays a criti...

    Authors: Wenbin Hua, Lin Xie, Chenpeng Dong, Guoyu Yang, Shouyuan Chi, Zhiqiang Xu, Cao Yang, Huiwen Wang and Xinghuo Wu
    Citation: Journal of Translational Medicine 2024 22:1071
    Content type: Research Published on:

  43. Iron overload is a pathological condition characterized by the abnormal accumulation of iron within the body, which may result from excessive iron intake, disorders of iron metabolism, or specific disease stat...

    Authors: Yangyang Zhao, Mengjiao Yang and Xiaoxue Liang
    Citation: Journal of Translational Medicine 2024 22:1057
    Content type: Research Published on:

  44. Alzheimer's disease (AD) is a prevalent irreversible neurodegenerative condition marked by gradual cognitive deterioration and neuronal loss. The mammalian Ste20-like kinase (MST1)–Hippo pathway is pivotal in ...

    Authors: Dongqing Cui, Haixia Liu, Lili Cao, Xiaowei Du, Dingxin Liu, Zhiping Liu, Tong Wang, Hui Yang, Xiaolei Zheng, Zhaohong Xie, Shunliang Xu, Jianzhong Bi and Ping Wang
    Citation: Journal of Translational Medicine 2024 22:1056
    Content type: Research Published on:

  45. Allergic rhinitis (AR) is a complex disorder with variable pathogenesis. Increasing evidence suggests that the LRRC8A is involved in maintaining cellular stability, regulating immune cell activation and functi...

    Authors: Linghui Meng, Dingqian Hao, Yuan Liu, Peng Yu, Jinfeng Luo, Chunhao Li, Tianjiao Jiang, JinZhuang Yu, Qian Zhang, Shengyang Liu and Li Shi
    Citation: Journal of Translational Medicine 2024 22:1034
    Content type: Research Published on:

  46. Explore the effects of mitochondrial transplantation (MT) after cardiopulmonary resuscitation (CPR) on the polarization of microglia/macrophages (MG/MΦ) and neurological function.

    Authors: Jie Zhu, Zhen Wang, Mengda Xu, Xuyuan Ma, Maozheng Shen, Jingyu Yan and Xiang Zhou
    Citation: Journal of Translational Medicine 2024 22:1014
    Content type: Research Published on:

  47. Osteoarthritis (OA) is a chronic degenerative joint condition characterised by cartilage deterioration and changes in bone morphology, resulting in pain and impaired joint mobility. Investigation into the path...

    Authors: Minghang Zhang, Junfeng Wu, Kehan Cai, Yang Liu, Botao Lu, Jiaojiao Zhang, Jianzhong Xu, Chenxi Gu and Tao Chen
    Citation: Journal of Translational Medicine 2024 22:1013
    Content type: Review Published on:

  48. Mitochondrial dysfunction is a critical factor in the pathogenesis of septic cardiomyopathy (SCM). Mitochondrial anchored protein ligase (MAPL), a small ubiquitin-like modifier (SUMO) E3 ligase, plays a signif...

    Authors: Yinghua Wang, Xiying Huang, Huanhuan Huo, Zhaohua Cai, Qingqi Ji, Yi Jiang, Fei Zhuang, Yi Li, Linghong Shen, Xia Wang and Ben He
    Citation: Journal of Translational Medicine 2024 22:1012
    Content type: Research Published on:

  50. Brain damage caused by acute hypoxia is associated with the physiological activities of mitochondria. Although mitochondria being dynamically regulated, our comprehensive understanding of the response of speci...

    Authors: Fengying Liu, Xueyang Lin, Xiaodong Wu, Xi Sui, Wenwen Ren, Qian Wang, Yongan Wang, Yuan Luo and Jiangbei Cao
    Citation: Journal of Translational Medicine 2024 22:974
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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