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Translational Cancer Biology

Section edited by Cristina Maccalli

This section aims to provide a platform for the communication and dissemination of advances in cancer biology and their translational applications. Studies considered for publication include those dissecting the mechanisms of transformation, progression and metastatization, the biology of cancer stem cells and their immunological properties, the mechanisms undergoing the epithelial-to mesenchymal (EMT) transition and tumor dormancy, their relationship with immune functions and the mechanisms undergoing cancer resistance to therapies. 

This section is also dedicated to those investigations dedicated to the translational aspects and the development of novel therapies related to the aforementioned themes and the identification of patient’s responsiveness and outcome to therapies.

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  1. Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, with high incidence and mortality rates, and the number of cases is expected to increase by 2030. Understanding the molecular mechan...

    Authors: Zhipeng Quan, Bo Peng, Kai Hu, Lixing Liang, Mingjiang Liu, Lijuan Liao, Shilian Chen, Jing Qin, Songqing He and Zeyuan Li
    Citation: Journal of Translational Medicine 2025 23:564
    Content type: Research Published on:

  3. Osteosarcoma (OS) is a primary bone malignancy characterized by early metastasis and generally poor prognosis. ESPN is highly expressed and plays an important role in regulating the aggressive phenotypes of se...

    Authors: Ruikai Zhou, Hongyu Wu, Hao You, Xiaofei Wang, Xiuchen Yuan, Zhengyi Sun, Dong Zhou, Yuqing Jiang and Yifei Shen
    Citation: Journal of Translational Medicine 2025 23:527
    Content type: Research Published on:

  4. Hepatocellular carcinoma (HCC) significantly affects the patient’s physical and mental health. Long non-coding RNA plasmacytoma variant translocation 1 (lncRNA PVT1) has been associated with the progression of...

    Authors: Shuaihui Wu, Qian Cheng, Yang Shi, Kunlei Wang, Zhinan Chen, Xinyin Li, Ping Jiang, Zhixiang Cheng, Zhiyong Yang and Bo Liao
    Citation: Journal of Translational Medicine 2025 23:500
    Content type: Research Published on:

  5. Ovarian cancer (OC) often presents at advanced stages with poor prognosis. Although poly(ADP-ribose) polymerase inhibitors (PARPi) offer clinical benefits, resistance remains a major challenge. This study inve...

    Authors: Huimin Xiao, Guiyun Cheng, Haocheng Zhang, Yao Liu, Zhongshao Chen, Yuehan Gao, Feng Gao, Yanling Liu, Shourong Wang and Beihua Kong
    Citation: Journal of Translational Medicine 2025 23:492
    Content type: Research Published on:

  6. SF3B4 encodes a core subunit of the U2-type spliceosome and is implicated in abnormal cell growth and tumorigenesis. However, its role in regulating gene expression and alternative splicing in hepatocellular c...

    Authors: HanFei Huang, Yuan Fang, ZhiTao Li, SiMing Qu, Bo Yuan, Kai Gan, ChengLong Yue, HaiJing Li, YuBo Wen and Zhong Zeng
    Citation: Journal of Translational Medicine 2025 23:441
    Content type: Research Published on:

  9. The epithelial-mesenchymal transition (EMT) is a critical process in cancer progression, facilitating tumor cells to develop invasive traits and augmenting their migratory capabilities. EMT is primed by tumor ...

    Authors: Yuqi Xie, Xuan Wang, Wenquan Wang, Ning Pu and Liang Liu
    Citation: Journal of Translational Medicine 2025 23:386
    Content type: Review Published on:

  10. Ovarian cancer (OC) is recognized as one of the deadliest forms of gynecological cancer, approximately two-thirds of patients have already developed metastasis when they are diagnosed. The function of transmem...

    Authors: Lili Yan, Zhaona Song, Lili Yi, Conghui Tian, Ruirui Zhang, Xuying Qin, Xiang Wang, Shaoda Ren, Xiaoping Ma, Xiaobing Wang, Xiaofeng Zhao, Feifei Wang, Jianmei Wei, Xiaodong Jia, Mingliang Gu, Fengjiao Yuan…
    Citation: Journal of Translational Medicine 2025 23:350
    Content type: Research Published on:

  11. Many studies have shown that F-box proteins regulate epithelial-mesenchymal transition, which is closely related to tumor metastasis. However, there is still limited research on the role of F-box proteins in r...

    Authors: Wuping Yang, Taile Jing, Cunjin Wu, Minghao Lu, Xiaolin Yao, Dan Xia and Ding Peng
    Citation: Journal of Translational Medicine 2025 23:335
    Content type: Research Published on:

  12. Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype with the worst prognosis, and there are no targeted treatments available. TNBC patients are more likely to develop metastases a...

    Authors: Xing Yao, Tan Yuen, Chen Qingchuan, Zhang Jianjun, Liu Yefu and Sun Shulan
    Citation: Journal of Translational Medicine 2025 23:284
    Content type: Research Published on:

  13. Embigin (EMB) is a transmembrane glycoprotein highly expressed in glioblastoma multiforme (GBM), yet its role in GBM progression remains unclear. In this study, we investigate the function of intracellular EMB...

    Authors: Bo Cheng, Jing Liu, Ling Gao, Ziwen Zhu, Yang Yang, Shangqi Liu and Xiaojin Wu
    Citation: Journal of Translational Medicine 2025 23:272
    Content type: Research Published on:

  14. Targeted therapy is an effective strategy for the treatment of advanced and metastatic pancreatic cancer, one of the leading causes for cancer-related death worldwide. To address the limitations of existing ta...

    Authors: Xiaolong Liu, Xueyan Zhang, Tingyu Zeng, Yali Chen, Liu Ye, Shuping Wang and Yulan Li
    Citation: Journal of Translational Medicine 2025 23:268
    Content type: Research Published on:

  15. Aberrant epigenetic and transcriptional events that drive cancer progression could be precisely targeted. We aimed to uncover the epigenetic roles of RBBP7 on breast cancer (BCa) stemness and metastasis.

    Authors: Yuanyin Xi, Ruoding Wang, Man Qu, Qinwen Pan, Minghao Wang, Xiang Ai, Zihan Sun, Chao Zhang, Peng Tang, Jun Jiang and Ying Hu
    Citation: Journal of Translational Medicine 2025 23:266
    Content type: Research Published on:

  16. Hepatocellular carcinoma (HCC) has a hidden onset and high malignancy. Its high metastasis, high recurrence, and short survival time have always been a difficult and hot spot in clinical practice. Our previous...

    Authors: Di Li, Li Xu, Ruyuan Liu, Zhaonv Yao, Chuanjun Zheng, Song Jin, Xuefeng Guo, Zhengbao Zhang, Shengkui Tan and Xiaonian Zhu
    Citation: Journal of Translational Medicine 2025 23:265
    Content type: Research Published on:

  17. Cancer-associated fibroblasts (CAFs) have been identified to drive chemotherapy resistance in triple-negative breast cancer (TNBC). This study evaluated the functions of CAFs-mediated suppressive ferroptosis i...

    Authors: KeJing Zhang, Lei Guo, Xin Li, Yu Hu and Na Luo
    Citation: Journal of Translational Medicine 2025 23:247
    Content type: Research Published on:

  18. Neural infiltration has been found in various cancers and the infiltrating nerves influence tumor growth and dissemination. In non-small cell lung cancer, pan-neuronal marker PGP9.5 was detected by immunohisto...

    Authors: Jie Mi, Wentian Zhang, Yijiu Ren, Lei Zhu, Bei Yang, Hao Wang and Liang Duan
    Citation: Journal of Translational Medicine 2025 23:246
    Content type: Research Published on:

  19. M6A modification is one of the most common regulatory mechanisms of gene expression in eukaryotic cells, influencing processes such as RNA splicing, degradation, stability, and protein translation. Studies hav...

    Authors: Xi Chen, Yixiao Yuan, Fan Zhou, Lihua Li, Jun Pu and Xiulin Jiang
    Citation: Journal of Translational Medicine 2025 23:245
    Content type: Review Published on:

  20. Cervical cancer remains one of the leading causes of cancer-related deaths among women globally, and there is still a need to research molecular targets that can be used for prognosis assessment and personaliz...

    Authors: Dongmei Zhang, Meiqi Zhao, Ping Jiang, Yunzhen Zhou, Xu Yan, Chong Zhou, Yu Mu, Shan Xiao, Guohua Ji, Nan Wu, Donglin Sun, Xiaobo Cui, Shangwei Ning, Hongxue Meng, Sheng Xiao and Yan Jin
    Citation: Journal of Translational Medicine 2025 23:244
    Content type: Research Published on:

  21. Clear cell renal cell carcinoma (ccRCC) is a prevalent urogenital malignancy characterized by heterogeneous patterns. Stemness is a pivotal factor in tumor progression, recurrence, and metastasis. Nevertheless...

    Authors: Jia Liu, Lin Yao, Yong Yang, Jinchao Ma, Ruijian You, Ziyi Yu and Peng Du
    Citation: Journal of Translational Medicine 2025 23:238
    Content type: Research Published on:

  22. The Jumonji domain-containing protein 6 (JMJD6), a histone arginine demethylase, is known to have a multifaceted and significant role on cancer progression. However, the specific function and mechanism of JMJD...

    Authors: Huanxiang Chen, Nan Xiao, Chenxing Zhang, Yang Li, Xiangzhuan Zhao, Ruike Zhang, Lu Bai, Qiaozhen Kang, Junhu Wan and Hongyang Liu
    Citation: Journal of Translational Medicine 2025 23:233
    Content type: Research Published on:

  23. How to select muscle-invasive bladder cancer (MIBC) patients who are sensitive to immunotherapy is an unmet medical need. This study aimed to explore the role of immunoproteasome subunits as a novel signature ...

    Authors: XinJian Wang, Hang You, Teng Zhang, Yuan Li, XinYu Chen, Michael Basler, QingMing Jiang, Han Chen, Nan Liu, Fang Yuan and Jun Li
    Citation: Journal of Translational Medicine 2025 23:228
    Content type: Research Published on:

  24. Cancer stem cells (CSCs) are crucial for lung adenocarcinoma (LUAD). This study investigates tumor stem cell gene signatures in LUAD using single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing (RNA-se...

    Authors: Fengyun Zhao, Mengting Chen, Tianjiao Wu, Mingfang Ji and Fugui Li
    Citation: Journal of Translational Medicine 2025 23:222
    Content type: Research Published on:

  25. Osteosarcoma (OS) is recognized as a prevalent primary bone malignancy, particularly affecting adolescents during their growth spurts. Despite its clinical significance, the underlying biological characteristi...

    Authors: Weilai Tong, Xinsheng Xie, Zhiguo Shu, Jiangbo Nie, Xianhe Yang, Feng Yang, Zhili Liu and Jiaming Liu
    Citation: Journal of Translational Medicine 2025 23:220
    Content type: Research Published on:

  26. 3-hydroxy-3-methylglutaryl-coenzymOHBe A(HMG-CoA) lyase (HMGCL) catalyzes the cleavage of HMG-CoA into acetyl-CoA and acetoacetic acid and serves as a rate-limiting enzyme in the metabolism of ketone bodies. W...

    Authors: Wenda Liu, Kezhou Xia, Xinghan Huang, Zhun Wei, Zicheng Wei, Xingyu Wang, Chen Xiong and Weichun Guo
    Citation: Journal of Translational Medicine 2025 23:219
    Content type: Research Published on:

  27. Colorectal cancer (CRC) initiating cells (CICs) possess self-renewal capabilities and are pivotal in tumor recurrence and resistance to conventional therapies, including immunotherapy. The mechanisms underlyin...

    Authors: Issam Tout, Salim Bougarn, Mohammed Toufiq, Neha Gopinath, Ola Hussein, Abbirami Sathappan, Evonne Chin-Smith, Fazulur Rehaman, Rebecca Mathew, Lisa Mathew, Kun Wang, Li Liu, Abdulrahman Salhab, Oleksandr Soloviov, Sara Tomei, Waseem Hasan…
    Citation: Journal of Translational Medicine 2025 23:193
    Content type: Research Published on:

  28. Second Primary Cancers (SPCs) are defined as cancers that develop either simultaneously or metachronously in the same individual who has been diagnosed with and survived one primary cancer. SPCs exhibit a high...

    Authors: Meiyuan Zeng, Anqi Lin, Aimin Jiang, Zhengang Qiu, Hongman Zhang, Shifu Chen, Mingyan Xu, Zaoqu Liu, Quan Cheng, Jian Zhang and Peng Luo
    Citation: Journal of Translational Medicine 2025 23:115
    Content type: Review Published on:

  29. It is worthwhile to establish a prognostic prediction model based on microenvironment cells (MCs) infiltration and explore new treatment strategies for triple-negative breast cancer (TNBC).

    Authors: Xian-Yan Yang, Nian Chen, Qian Wen, Yu Zhou, Tao Zhang, Ji Zhou, Cheng-Hui Liang, Li-Ping Han, Xiao-Ya Wang, Qing-Mei Kang, Xiao-Xia Zheng, Xue-Jia Zhai, Hong-Ying Jiang, Tian-Hua Shen, Jin-Wei Xiao, Yu-Xin Zou…
    Citation: Journal of Translational Medicine 2025 23:61
    Content type: Research Published on:

  31. Human kinesin family member 11 (KIF11) plays a vital role in regulating the cell cycle and is implicated in the tumorigenesis and progression of various cancers, but its role in endometrial cancer (EC) is stil...

    Authors: Biying Wang, Lunmin Bao, Xiaoduo Li, Guang Sun, Wu Yang, Nanzi Xie, Ling Lei, Wei Chen, Hailong Zhang, Man Chen, Xing Zhao, Xiufang Wan, Rui Yuan and Hongmei Jiang
    Citation: Journal of Translational Medicine 2025 23:48
    Content type: Research Published on:

  32. Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in China, commonly associated with undifferentiated cell types and Epstein-Barr virus (EBV) infection. The presence of intense lymphocytic infiltration ...

    Authors: Huilin Wang, Yuting Zhan, Jiadi Luo, Weiyuan Wang and Songqing Fan
    Citation: Journal of Translational Medicine 2025 23:38
    Content type: Review Published on:

  33. The most common malignant type of kidney cancer is clear cell renal cell carcinoma (ccRCC). The expression levels of hyaluronan-mediated motility receptor (HMMR) in many tumor types are significantly elevated....

    Authors: Xinyang Niu, Dingheng Lu, Weitao Zhan, Jiazhu Sun, Yuxiao Li, Yuchen Shi, Kai Yu, Suyuelin Huang, Xueyou Ma, Xiaoyan Liu and Ben Liu
    Citation: Journal of Translational Medicine 2025 23:36
    Content type: Research Published on:

  34. Gasdermin D (GSDMD) is a key effector molecule that activates pyroptosis through its N terminal domain (GSDMD-NT). However, the roles of GSDMD in colorectal cancer (CRC) have not been fully explored. The role ...

    Authors: Ying Li, Jiayao Chen, Huijun Liang, Qindan Du, Jingjie Shen and Xiaoying Wang
    Citation: Journal of Translational Medicine 2024 22:1170
    Content type: Research Published on:

  35. This study aims to investigate the molecular mechanisms by which YWHAG (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma) promotes metastasis in bladder cancer. Specifically, it see...

    Authors: Tai Tian, Shiming He, Han Hao, Bao Guan, Yanqing Gong, Jian Fan, Zhenpeng Zhu, Wenzhi Gao, Yucai Wu, Ninghan Feng, Aixiang Wang, Yuexian Guo and Xuesong Li
    Citation: Journal of Translational Medicine 2024 22:1159
    Content type: Research Published on:

  36. Mitochondrial transcription elongation factor (TEFM) is a recently discovered factor involved in mitochondrial DNA replication and transcription. Previous studies have reported that abnormal TEFM expression ca...

    Authors: Jia Lei, Qingguo Zhu, Jianghao Guo, Jiaxing Chen, Lixia Qi, Mengmeng Cui, Zhixiong Jiang, Chunhui Fan, Lin Wang, Tianjiao Lai, Yuxi Jin, Lulu Si, Yana Liu, Qi Yang, Dengke Bao and Ruixia Guo
    Citation: Journal of Translational Medicine 2024 22:1151
    Content type: Research Published on:

  37. Aberrant alternative splicing (AS) contributes to tumor progression. A crucial component of AS is cleavage and polyadenylation specificity factor 4 (CPSF4). It remains unclear whether CPSF4 plays a role in tri...

    Authors: Guansheng Zhong, Qinyan Shen, Xinli Zheng, Kun Yu, Hongjiang Lu, Bajin Wei, Haidong Cui, Zhijun Dai and Weiyang Lou
    Citation: Journal of Translational Medicine 2024 22:1149
    Content type: Research Published on:

  38. The evaluation of the efficacy of immunotherapy is of great value for the clinical treatment of bladder cancer. Graph Neural Networks (GNNs), pathway analysis and multi-omics analysis have shown great potentia...

    Authors: Shuai Ren, Yongjian Lu, Guangping Zhang, Ke Xie, Danni Chen, Xiangna Cai and Maodong Ye
    Citation: Journal of Translational Medicine 2024 22:1141
    Content type: Research Published on:

  39. Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with high rates of morbidity and mortality, largely because of its late diagnosis and metastatic potential. Lactate metabolism and protein lactylation...

    Authors: Changlin Liu, Chuping Ni, Chao Li, Hu Tian, Weiquan Jian, Yuping Zhong, Yanqing Zhou, Xiaoming Lyu, Yuanbin Zhang, Xiao-Jun Xiang, Chao Cheng and Xin Li
    Citation: Journal of Translational Medicine 2024 22:1116
    Content type: Research Published on:

  41. Colon adenocarcinoma (COAD) ranks as the third most prevalent and lethal cancer in 2020, with metastasis being the primary cause of cancer-related mortality. A comprehensive understanding of the mechanism unde...

    Authors: Zhengyan Chang, Runzhi Huang, Jiaqi Song, Zhenyu Li, Man Pi, Shuyuan Xian, Jingcheng Zhang, Jinglei Huang, Ruting Xie, Guo Ji, Dongyan Han and Qiongyi Huang
    Citation: Journal of Translational Medicine 2024 22:1029
    Content type: Research Published on:

  42. Pseudomyxoma peritonei (PMP) is a rare malignant peritoneal tumor that readily recurs and metastasizes. Studies have shown that cancer stem cells (CSCs) play an important role in tumor recurrence, metastasis, ...

    Authors: Haipeng Zhou, Hongbin Xu, Shaojun Pang, Lubiao An, Guanjun Shi, Chong Wang, Pu Zhang, Xiwen Fan, Jing Yang, Shiyi Tang, Yiyan Lu, Lifei Yu, Feng Chen and Ruiqing Ma
    Citation: Journal of Translational Medicine 2024 22:1022
    Content type: Research Published on:

  43. The complexity of tumors and the challenges associated with treatment often stem from the limitations of existing models in accurately replicating authentic tumors. Recently, organoid technology has emerged as...

    Authors: Guolong Zeng, Yifan Yu, Meiting Wang, Jiaxing Liu, Guangpeng He, Sixuan Yu, Huining Yan, Liang Yang, Hangyu Li and Xueqiang Peng
    Citation: Journal of Translational Medicine 2024 22:1007
    Content type: Review Published on:

  44. Aerobic glycolysis is a tumor cell phenotype and a hallmark in cancer research. The alternative splicing of the pyruvate kinase M (PKM) gene regulates the expressions of PKM1/2 isoforms and the aerobic glycolysis...

    Authors: Jia-Yi Hou, Xiao-Ling Wang, Hai-Jiao Chang, Xi-Xing Wang, Shu-Lan Hao, Yu Gao, Gang Li, Li-Juan Gao, Fu-Peng Zhang, Zhi-Jie Wang, Jian-Yun Shi, Ning Li and Ji-Min Cao
    Citation: Journal of Translational Medicine 2024 22:995
    Content type: Research Published on:

  47. The serine/threonine/tyrosine kinase 1 (STYK1) is a receptor protein-tyrosine kinase (RPTK)-like molecule that is detected in several human organs. STYK1 plays an important role in promoting tumorigenesis and ...

    Authors: Junming He, Yuexi He, Ruojia Biao, Yuqing Wei, Zhongjun Dong and Juan Du
    Citation: Journal of Translational Medicine 2024 22:943
    Content type: Research Published on:

  48. N-acetyltransferase 10 (NAT10) plays a crucial role in the occurrence and development of various tumors. However, the current regulatory mechanism of NAT10 in tumors is limited to its presence in tumor cells. ...

    Authors: Teng Cai, Jianye Dai, Yanyan Lin, Zhongtian Bai, Jingdong Li and Wenbo Meng
    Citation: Journal of Translational Medicine 2024 22:875
    Content type: Research Published on:

  49. Gene methylation and the immune-related tumor microenvironment (TME) are highly correlated in tumor progression and therapeutic efficacy. Although both of them can be used to predict the clinical outcomes of c...

    Authors: Jie Sun, Songli Shi, Chao Sun, Jiangping Wang, Xiaohui Yang, Zhengduo Yang, Jing Xu and Shiwu Zhang
    Citation: Journal of Translational Medicine 2024 22:861
    Content type: Research Published on:

  50. This study aimed to investigate the effect and potential mechanism of evodiamine (EVO) on proliferation and apoptosis of nasopharyngeal carcinoma (NPC) cells. EVO inhibited proliferation, blocked cell cycle pr...

    Authors: Jie Liu, Lan He, Wenqing Zhang, Yinggang Tang, Jingying Fan and Yingchun He
    Citation: Journal of Translational Medicine 2024 22:859
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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