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Translational Ophthalmology

Section edited by Geoffrey Broadhead and Levon Khachigian

This section is focused on the rapidly expanding field of translational medicine as it relates to ophthalmology and vision science, as well as the role of ophthalmology in guiding the diagnosis and care of other (non-ophthalmic) diseases. Translational Ophthalmology is a section primarily aimed at (but not limited to) studies focused on mechanisms and development of novel therapies for ophthalmic conditions, new biomarkers of ocular pathology, and the role of ophthalmology and ophthalmic findings in the diagnosis and management of systemic medical conditions.

The section aims to provide a platform for research and review articles into the expanding field of translational ophthalmology and will facilitate the publication and discussion of high-quality peer-reviewed studies in this area.

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  1. Myopia presents a noteworthy global health concern, urging exploration of innovative treatments. The role of intraocular pressure (IOP) in regulating the progression of myopia has been controversial.

    Authors: Peiyuan Wang, Kangjie Kong, Jiaxuan Jiang, Jingwen Jiang, Zihong Xie, Fengbin Lin, Yunhe Song, Xiuli Fang, Ling Jin, Fei Li, Wei Wang, Shaolin Du, Zhuoxing Shi, Junwen Zeng, Xiulan Zhang and Shida Chen
    Citation: Journal of Translational Medicine 2025 23:556
    Content type: Research Published on:

  2. Isotretinoin is a vitamin A derivative used as a first-line treatment for moderate to severe acne. One of its most frequent side effects is dry eye disease (DED), in which tear film instability and neurosensor...

    Authors: Alberto Barros, Javier Lozano-Sanroma, Juan Queiruga-Piñeiro, Luis Fernández-Vega-Cueto, Cristina Sánchez-Fernández, Jesús Merayo-Lloves and Ignacio Alcalde
    Citation: Journal of Translational Medicine 2025 23:550
    Content type: Research Published on:

  3. Diabetic retinopathy (DR), a microvascular complication of diabetes mellitus (DM), represents the predominant cause of preventable vision loss in working-age populations globally. While the pathophysiological ...

    Authors: Yeanqi Jin, Junbin Liu, Xueli Zhang, Liang Zhang, Ying Cui, Xiaoyang Luo, Haoxian Zhu, Zhifan Chen, Mengya Liu, Xiyu Wu, Xinyu Chen, Shuoxin Liao, Guanrong Wu, Xiang Fang and Qianli Meng
    Citation: Journal of Translational Medicine 2025 23:476
    Content type: Research Published on:

  4. Heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) plays a vital role in angiogenesis, when its nucleic acid-binding domain is occupied by transthyretin (TTR), the neovascularization of human retinal mic...

    Authors: Yixiu Chen, Lu Ye, Shujing Cui, Jun Shao and Yu Xin
    Citation: Journal of Translational Medicine 2025 23:458
    Content type: Research Published on:

  6. Uveitis is a common recurrent autoimmune disease that seriously endangers the visual health of patients. MicroRNAs (miRNAs) are closely related to a series of autoimmune diseases.

    Authors: Xuewei Yin, Huixia Wei, Lijie Guo, Bin Liu, Yuan Peng, Mengxian Zhou, Yan Qiu, Ruyi Qu, Yane Gao, Qiuxin Wu, Wenjun Jiang, Hongsheng Bi and Dadong Guo
    Citation: Journal of Translational Medicine 2025 23:426
    Content type: Research Published on:

  7. Thyroid-associated ophthalmopathy (TAO) is a thyroid function-related, organ-specific autoimmune disease that primarily leads to specific reactive changes and tissue remodeling in the periocular region. The ex...

    Authors: Xuemei Li, Siyi Wang, Hanwen Cao, Simin Xu, Chao Xiong, Jinhai Yu, Yunxiu Chen, Zhangjun Ren, Min Li, Ying Hu, Puying Gan, Qihua Xu, Yaohua Wang and Hongfei Liao
    Citation: Journal of Translational Medicine 2025 23:423
    Content type: Research Published on:

  8. Congenital Stationary Night Blindness (CSNB) is a non-progressive hereditary eye disease that primarily affects the retinal signal processing, resulting in significantly reduced vision under low-light conditio...

    Authors: Yi Zhang, Siqi Lin, Lingqi Yu, Xiang Lin, Shuai Qu, Qingyang Ye, Mengting Yu, Wenfeng Chen and Wenjie Wu
    Citation: Journal of Translational Medicine 2025 23:392
    Content type: Review Published on:

  10. Platelet-derived growth factor receptor β (PDGFRβ) is the principal PDGFR isoform in retinal pigment epithelial (RPE) cells from the epiretinal membranes of patients with proliferative vitreoretinopathy (PVR)....

    Authors: Duo Li, Minli Linghu, Jisen Tang, Gukun Yang, Chuanwu Li, Hang Yao, Hetian Lei, Yikeng Huang and Xionggao Huang
    Citation: Journal of Translational Medicine 2025 23:374
    Content type: Research Published on:

  11. The development of age-related macular degeneration (AMD) is influenced by risk factors that contribute to inflammatory processes, cellular stress responses, and a dysregulation of the complement system. Given...

    Authors: Juliane Schikora, Aaron Dort, Hannah N. Wolf, Mihály Józsi, Richard B. Pouw, Thomas Bertelmann, Dirk Bahlmann, Christian van Oterendorp, Nicolas Feltgen, Hans Hoerauf, Diana Pauly and Jannis Klemming
    Citation: Journal of Translational Medicine 2025 23:317
    Content type: Research Published on:

  12. Proliferative diabetic retinopathy (PDR) is among the primary causes of blindness in individuals with diabetes. Elevated lactate levels have been identified as a critical biomarker associated with the prognosi...

    Authors: Keyi Zou, Xue Li, Bibo Ren, Fu Cheng, Jian Ye and Zelin Ou
    Citation: Journal of Translational Medicine 2025 23:310
    Content type: Research Published on:

  13. In patients with advanced glaucoma, lesions frequently extend beyond the eye and affect other organs. However, early distal consequences of elevated intraocular pressure (IOP) remain unclear. This study aimed ...

    Authors: Ya Zhang, Jia Zhao, Jian Zhou, Zhen Jiang, Kaihui Cheng, Caifeng Lei and Ling Yu
    Citation: Journal of Translational Medicine 2025 23:200
    Content type: Research Published on:

  14. Previous studies have suggested oxidative stress may play a key role in the pathogenesis of retinopathy, while evidence from observational studies directly linking oxidative biomarkers to clinically relevant o...

    Authors: Xiangliang Liu, Yu Chang, Yuguang Li, Yingrui Liu, Wei Song, Jin Lu, Naifei Chen and Jiuwei Cui
    Citation: Journal of Translational Medicine 2025 23:94
    Content type: Research Published on:

  15. Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, commonly causing sensory disturbances, motor weakness, impaired gait, incoordination and optic neuritis (ON). Accor...

    Authors: Bin Tong, Xin Zhang, Haijian Hu, Huayi Yang, Xifeng Wang, Maolin Zhong, Fan Yang and Fuzhou Hua
    Citation: Journal of Translational Medicine 2025 23:87
    Content type: Review Published on:

  17. The activation of macrophages or microglia in patients' whole body or local eyes play significant roles in diabetic retinopathy (DR). Mitochondrial function regulates the inflammatory polarization of macrophag...

    Authors: Weifeng Liu, Bin Tong, Jian Xiong, Yanfang Zhu, Hongwei Lu, Haonan Xu, Xi Yang, Feifei Wang, Peng Yu and Yunwei Hu
    Citation: Journal of Translational Medicine 2025 23:23
    Content type: Research Published on:

  18. Diabetic retinopathy (DR) is the most important complication of Type 2 Diabetes (T2D) in eyes. Despite its prevalence, the early detection and management of DR continue to pose considerable challenges. Our res...

    Authors: Guoguo Yi, Zhengran Li, Yuxin Sun, Xinyu Ma, Zijin Wang, Jinken Chen, Dong Cai, Ziran Zhang, Zejun Chen, Fanye Wu, Mingzhe Cao and Min Fu
    Citation: Journal of Translational Medicine 2024 22:1146
    Content type: Research Published on:

  19. Early detection of lifestyle factors, skin and hair color, circulating parameters, and metabolic comorbidities is crucial for personalized prevention and treatment of early age-related macular degeneration (AM...

    Authors: Gang Shen, Yaqiong Chen, Jiahao Chen, Lingling Wang, Huanhuan Cheng, Bo Hu and Jiao Gong
    Citation: Journal of Translational Medicine 2024 22:988
    Content type: Research Published on:

  20. Retinal neurovascular unit (NVU) is a multi-cellular structure that consists of the functional coupling between neural tissue and vascular system. Disrupted NVU will result in the occurrence of retinal and cho...

    Authors: Lulu Sha, Yameng Zhao, Siyu Li, Dong Wei, Ye Tao and Yange Wang
    Citation: Journal of Translational Medicine 2024 22:898
    Content type: Review Published on:

  21. Diabetic retinopathy (DR), the principal cause of acquired blindness among the working-age population, is the most frequent microvascular complication of diabetes. Although metabolic disorders are hypothesized...

    Authors: Lan Zhou, Hongyan Sun, Gongyi Chen, Cunzi Li, Dan Liu, Xurui Wang, Ting Meng, Zhenyou Jiang, Shu Yang and Ming-Ming Yang
    Citation: Journal of Translational Medicine 2024 22:870
    Content type: Research Published on:

  22. The increasing incidence of diabetes mellitus has established diabetic cataracts (DC) as a significant worldwide public health issue. The mechanisms underlying DC remain unknown, and effective prevention and t...

    Authors: Su Dong, Jiajia Zhang, Yushan Fu, Gege Tang, Jianfeng Chen, Dawei Sun, Yanhua Qi and Nan Zhou
    Citation: Journal of Translational Medicine 2024 22:865
    Content type: Research Published on:

  23. Ocular toxicity is a severe adverse effect that limits the chronic clinical use of the antiarrhythmic drug amiodarone. Here, we aimed to evaluate the cytoprotective effect of artemisinin and explore the potent...

    Authors: Chao Yang, Xia Zhao, Wenshu Zhou, Qin Li, Philip Lazarovici and Wenhua Zheng
    Citation: Journal of Translational Medicine 2024 22:844
    Content type: Research Published on:

  24. To explore the functional and morphological variations of retinal vessels in diabetes with no clinically detectable retinopathy (NDR) and mild non-proliferative diabetic retinopathy (NPDR) and to establish a h...

    Authors: Jinze Zhang, Ke Ma, Zhongzhou Luo, Gengyuan Wang, Ziqing Feng, Yuancong Huang, Keyi Fei, Yushuang Liu, Honghui Xia, Jin Yuan and Peng Xiao
    Citation: Journal of Translational Medicine 2024 22:798
    Content type: Research Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2024 22:850

  25. The cornea is the outermost layer of the eye and plays an essential role in our visual system. Limbal epithelial stem cells (LESCs), which are localized to a highly regulated limbal niche, are the master condu...

    Authors: Shiding Li, Hao Sun, Liangbo Chen and Yao Fu
    Citation: Journal of Translational Medicine 2024 22:794
    Content type: Review Published on:

  26. Glaucoma, a blinding eye disease with optic neuropathy, is usually associated with elevated intraocular pressure (IOP). The currently available pharmacological and surgical treatments for glaucoma have signifi...

    Authors: Samarendra Mohanty, Subrata Batabyal, Chinenye Idigo, Darryl Narcisse, Sanghoon Kim, Houssam Al-Saad, Michael Carlson, Kissaou Tchedre and Adnan Dibas
    Citation: Journal of Translational Medicine 2024 22:791
    Content type: Research Published on:

  27. Vascular dysregulation is one of the major risk factors of glaucoma, and endothelin-1 (ET-1) may have a role in the pathogenesis of vascular-related glaucoma. Fruit extract from Lycium Barbarum (LB) exhibits a...

    Authors: Yamunadevi Lakshmanan, Francisca Siu Yin Wong, Kwok-Fai So and Henry Ho-Lung Chan
    Citation: Journal of Translational Medicine 2024 22:727
    Content type: Research Published on:

  28. Myopia is one of the most common eye diseases in children and adolescents worldwide, and scleral remodeling plays a role in myopia progression. However, the identity of the initiating factors and signaling pat...

    Authors: Ruixue Zhang, Ying Wen, Jinpeng Liu, Jiawen Hao, Yuan Peng, Miao Zhang, Yunxiao Xie, Zhaohui Yang, Xuewei Yin, Yongwei Shi, Hongsheng Bi and Dadong Guo
    Citation: Journal of Translational Medicine 2024 22:710
    Content type: Research Published on:

  30. Intravitreal injections of angiogenesis inhibitors have proved efficacious in the majority of patients with ocular angiogenesis. However, one-fourth of all treated patients fail to derive benefits from intravi...

    Authors: Yan Ma, Ying Zhang, Hui-Ying Zhang, Ya Zhao, Xiu-Miao Li, Yi-Fei Jiang, Mu-Di Yao, Qin Jiang and Biao Yan
    Citation: Journal of Translational Medicine 2024 22:562
    Content type: Research Published on:

  31. Diabetic macular edema (DME) is the leading cause of visual impairment in patients with diabetes mellitus (DM). The goal of early detection has not yet achieved due to a lack of fast and convenient methods. Th...

    Authors: Guanrong Wu, Yijun Hu, Qibo Zhu, Anyi Liang, Zijing Du, Chunwen Zheng, Yanhua Liang, Yuxiang Zheng, Yunyan Hu, Lingcong Kong, Yingying Liang, Maman Lawali Dan Jouma Amadou, Ying Fang, Yuejuan Liu, Songfu Feng, Ling Yuan…
    Citation: Journal of Translational Medicine 2024 22:523
    Content type: Research Published on:

  32. Myopia is one of the eye diseases that can damage the vision of young people. This study aimed to explore the protective role of miR-92b-3p against DNA damage and apoptosis in retinal tissues of negative lens-...

    Authors: Jinpeng Liu, Bo Bao, Tuling Li, Zhaohui Yang, Yongle Du, Ruixue Zhang, Jizhao Xin, Jiawen Hao, Guimin Wang, Hongsheng Bi and Dadong Guo
    Citation: Journal of Translational Medicine 2024 22:511
    Content type: Research Published on:

  33. Diabetic retinopathy (DR) is the leading cause of blinding eye disease among working adults and is primarily attributed to the excessive proliferation of microvessels, which leads to vitreous hemorrhage and re...

    Authors: Runze Wang, Wei Xue, Feifei Kan, Huiying Zhang, Di Wang, Lei Wang and Jianwen Wang
    Citation: Journal of Translational Medicine 2024 22:476
    Content type: Research Published on:

  34. Corneal injuries, often leading to severe vision loss or blindness, have traditionally been treated with the belief that limbal stem cells (LSCs) are essential for repair and homeostasis, while central corneal...

    Authors: Ruijue Ma, Yingxi Li, Xiaoli Dong, Yiming Zhang, Xiaosu Chen, Yue Zhang, Haohan Zou and Yan Wang
    Citation: Journal of Translational Medicine 2024 22:458
    Content type: Research Published on:

  35. The duration of type 2 diabetes mellitus (T2DM) and blood glucose levels have a significant impact on the development of T2DM complications. However, currently known risk factors are not good predictors of the...

    Authors: Mingqian He, Guixue Hou, Mengmeng Liu, Zhaoyi Peng, Hui Guo, Yue Wang, Jing Sui, Hui Liu, Xiaoming Yin, Meng Zhang, Ziyi Chen, Patrick C.N. Rensen, Liang Lin, Yanan Wang and Bingyin Shi
    Citation: Journal of Translational Medicine 2024 22:448
    Content type: Research Published on:

  36. Retinal ischemia/reperfusion (RIR) is implicated in various forms of optic neuropathies, yet effective treatments are lacking. RIR leads to the death of retinal ganglion cells (RGCs) and subsequent vision loss...

    Authors: Jiawen Wu, Daowei zhang, Hongli Liu, Jufeng Li, Ting Li, Jihong Wu and Shenghai Zhang
    Citation: Journal of Translational Medicine 2024 22:447
    Content type: Research Published on:

  37. Retinal detachment (RD) is a vision-threatening disorder of significant severity. Individuals with high myopia (HM) face a 2 to 6 times higher risk of developing RD compared to non-myopes. The timely identific...

    Authors: Shengjie Li, Meiyan Li, Jianing Wu, Yingzhu Li, Jianping Han, Yunxiao Song, Wenjun Cao and Xingtao Zhou
    Citation: Journal of Translational Medicine 2024 22:405
    Content type: Research Published on:

  38. Diabetic macular edema (DME) is a leading cause of vision loss in patients with diabetes. This study aimed to develop and evaluate an OCT-omics prediction model for assessing anti-vascular endothelial growth f...

    Authors: Zhishang Meng, Yanzhu Chen, Haoyu Li, Yue Zhang, Xiaoxi Yao, Yongan Meng, Wen Shi, Youling Liang, Yuqian Hu, Dan Liu, Manyun Xie, Bin Yan and Jing Luo
    Citation: Journal of Translational Medicine 2024 22:358
    Content type: Research Published on:

  39. Diabetic retinopathy (DR) is the foremost cause of vision loss among the global working-age population, and statins are among the most frequently prescribed drugs for lipid management in patients with DR. The ...

    Authors: Chengming Chen, Huan Zhang, Yanyan Lan, Weiming Yan, Sida Liu, Yixuan Chen, Tingke Xie, Jiayi Ning, Xiaolong Yan, Lei Shang and Jing Han
    Citation: Journal of Translational Medicine 2024 22:298
    Content type: Research Published on:

  40. Global myopia prevalence poses a substantial public health burden with vision-threatening complications, necessitating effective prevention and control strategies. Precise prediction of spherical equivalent (S...

    Authors: Jing Zhao, Yanze Yu, Yiming Li, Feng Li, Zhe Zhang, Weijun Jian, Zhi Chen, Yang Shen, Xiaoying Wang, Zhengqiang Ye, Chencui Huang and Xingtao Zhou
    Citation: Journal of Translational Medicine 2024 22:289
    Content type: Research Published on:

  41. Patients with spondyloarthritis (SpA)/HLA-B27-associated acute anterior uveitis (AAU) experience recurring acute flares, which pose significant visual and financial challenges. Despite established links betwee...

    Authors: Shuming Chen, Weidi Huang, Qiaoqian Wan, Zichun Tang, Xie Li, Fang Zeng, Shuyan Zheng, Zhuo Li and Xiao Liu
    Citation: Journal of Translational Medicine 2024 22:271
    Content type: Research Published on:

  42. In diabetic retinopathy (DR), hypoxia-inducible factor (HIF-1α) induces oxidative stress by upregulating glycolysis. This process leads to neurodegeneration, particularly photoreceptor cell damage, which furth...

    Authors: Bolin Chen, Jing Zou, Lihui Xie, Yinjun Cai, Bowen Li, Wei Tan, Jinhaohao Huang, Fangling Li and Huizhuo Xu
    Citation: Journal of Translational Medicine 2024 22:245
    Content type: Research Published on:

  43. Retinal degenerative disorders (RDDs) cause vision loss by damaging retinal neurons and photoreceptors, affecting individuals of all ages. Cell-based therapy has emerged as an effective approach for the treatm...

    Authors: Alireza Soltani Khaboushan, Negar Ebadpour, Mohammad Mehdi Johari Moghadam, Zahra Rezaee, Abdol-Mohammad Kajbafzadeh and Masoumeh Majidi Zolbin
    Citation: Journal of Translational Medicine 2024 22:227
    Content type: Review Published on:

  44. Hypertension influences the inflammatory pathological changes in the retina. The function of the inflammasomes is significant. To see if Sirtuin 1 (SIRT1) regulates angiotensin II (Ang II)-induced hypertensive...

    Authors: Jing Li, Xiaochen Wang, Jie Bai, Huangzhao Wei, Wenbo Wang and Shuai Wang
    Citation: Journal of Translational Medicine 2024 22:155
    Content type: Research Published on:

  45. Retinitis pigmentosa is the prevailing genetic cause of blindness in developed nations with no effective treatments. In the pursuit of unraveling the intricate dynamics underlying this complex disease, mechani...

    Authors: Marina Esteban-Medina, Carlos Loucera, Kinza Rian, Sheyla Velasco, Lorena Olivares-González, Regina Rodrigo, Joaquin Dopazo and Maria Peña-Chilet
    Citation: Journal of Translational Medicine 2024 22:139
    Content type: Research Published on:

  46. Unilateral high myopia (uHM), commonly observed in patients with retinal diseases or only with high myopia, is frequently associated with amblyopia with poor prognosis. This study aims to reveal the clinical a...

    Authors: Yi Jiang, Xueshan Xiao, Wenmin Sun, Yingwei Wang, Shiqiang Li, Xiaoyun Jia, Panfeng Wang, J. Fielding Hejtmancik and Qingjiong Zhang
    Citation: Journal of Translational Medicine 2024 22:75
    Content type: Research Published on:

  47. Radiomics analysis of orbital magnetic resonance imaging (MRI) shows preliminary potential for intravenous glucocorticoid (IVGC) response prediction of thyroid eye disease (TED). The current region of interest...

    Authors: Haiyang Zhang, Mengda Jiang, Hoi Chi Chan, Huijie Zhang, Jiashuo Xu, Yuting Liu, Ling Zhu, Xiaofeng Tao, Duojin Xia, Lei Zhou, Yinwei Li, Jing Sun, Xuefei Song, Huifang Zhou and Xianqun Fan
    Citation: Journal of Translational Medicine 2024 22:56
    Content type: Research Published on:

  48. Age-related macular degeneration (AMD) is an irreversible eye disease that can cause blurred vision. Regular exercise has been suggested as a therapeutic strategy for treating AMD, but how exercise improves AM...

    Authors: ChangHyuk Kwon, Wonjun Cho, Sung Woo Choi, Heeseung Oh, A. M. Abd El-Aty, Ibrahim Gecili, Ji Hoon Jeong and Tae Woo Jung
    Citation: Journal of Translational Medicine 2024 22:38
    Content type: Research Published on:

  49. Electrical activity has a crucial impact on the development and survival of neurons. Numerous recent studies have shown that noninvasive electrical stimulation (NES) has neuroprotective action in various retin...

    Authors: Jiaxian Li, Wei Zhou, Lina Liang, Yamin Li, Kai Xu, Xiaoyu Li, Ziyang Huang and Yu Jin
    Citation: Journal of Translational Medicine 2024 22:28
    Content type: Review Published on:

  50. Diabetes mellitus (DM) is a progressive disease that involves multiple organs due to increased blood glucose, and diabetic retinopathy (DR) is the main complication of DM in the eyes and causes irreversible vi...

    Authors: Yihan Wang, Yujuan Liu, Junwei Fang, Xindan Xing, Hanying Wang, Xin Shi, Xinyi Liu, Tian Niu and Kun Liu
    Citation: Journal of Translational Medicine 2024 22:2
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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