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Cardiovascular, Metabolic and Lipoprotein Translation

Section edited by Tommaso Angelone
© Juan Gärtner/ stock.adob

This section aims to speed mechanistic understanding, development of novel diagnostics and potential therapeutic targets within cardiovascular, metabolic diseases and lipoprotein diseases. The section is open to experiments involving cellular models, animal models, observational studies and clinical trials that are distinguished for their novelty in approach, design or indication, timeliness, and unique ability to translate laboratory concepts from the bench to the bedside.

Highest priority will be given to those manuscripts which are specifically focused on cardiovascular, metabolic and lipid disorders which enrich understanding of disease mechanism, novel therapeutics and state-of-the-art scientific technique.

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  1. Immune-related myocarditis induced by immune checkpoint inhibitors (ICIs) is a rare immune-related adverse event (irAE) but is characterized by a high mortality rate. However, the specific pathological mechani...

    Authors: Boyu Sun, Ziyu Xun, Zixiang Zhou, Nan Zhang, Mingjian Piao, Chengjie Li, Jiongyuan Li, Shuofeng Li, Longhao Zhang, Xiangqi Chen, Hanping Wang and Haitao Zhao
    Citation: Journal of Translational Medicine 2025 23:555
  2. Extracellular vesicles (EVs) are membrane-bound structures released by all cell types. They play a critical role in intercellular communication by transferring their cargo, comprising proteins, lipids, metabol...

    Authors: Riccardo Di Febo, Zeeba Saeed, Francesco Serafini, Davide Brocco, Francesca D’Ascanio, Andrea Delli Pizzi, Nicola Tinari, Rossella Crescitelli, Paola Lanuti and Giulia Renda
    Citation: Journal of Translational Medicine 2025 23:553
  3. Limited access to echocardiography can delay the diagnosis of suspected heart failure (HF), which in turn postpones the initiation of optimal guideline-directed medical therapy. Although natriuretic peptides l...

    Authors: Narainrit Karuna, Claire Tonry, Mark Ledwidge, Nadezhda Glezeva, Joe Gallagher, Ken McDonald and Chris J. Watson
    Citation: Journal of Translational Medicine 2025 23:546
  4. The rise of hypertension in children has been increasingly associated with hyperhomocysteinemia (HHcy), which is recognized as a major risk factor. However, the underlying mechanisms linking homocysteine and h...

    Authors: Baoling Bai, Lingyun Liu, Yanyan Liu, Shuangshuang Yang, Haojie Wu, Kexin Zhang, Lin Shi and Qin Zhang
    Citation: Journal of Translational Medicine 2025 23:525
  5. Vascular smooth muscle cells loaded with cholesterol (foam-VSMCs) play a crucial role in the progression of human atherosclerosis. Exchange Protein Directly Activated by cAMP 1 (EPAC1) is a critical protein in...

    Authors: Eduardo Garcia, Lene Claudi, Maria Teresa La Chica Lhoëst, Anna Polishchuk, Valerie Samouillan, Aleyda Benitez Amaro, Janet Pinero, Joan Carles Escolà-Gil, Eduard Sabidó, Ruben Leta, David Vilades and Vicenta Llorente Cortes
    Citation: Journal of Translational Medicine 2025 23:523
  6. The optimal management strategy for new-onset atrial fibrillation (NOAF) in patients with sepsis remains unclear. This study aimed to investigate and compare the associations of rhythm control medications vers...

    Authors: Cuilian Weng, Jian Lin, Qinghua Liu, Chang-hong Zou, Mingyu Zheng, Tingting Jiang, Linqian Jiang, Xiao-Feng Zhuang and Hangwei Feng
    Citation: Journal of Translational Medicine 2025 23:512
  7. Long QT Syndrome Type-2 (LQT2) is due to loss-of-function KCNH2 variants. KCNH2 encodes Kv11.1 that forms a delayed-rectifier potassium channel in the brain and heart. LQT2 is associated with arrhythmias, seizure...

    Authors: Veronica Singh, Kyle T. Wagner, Laura G. Williams, Justin M. Ryan, Katherine R. Keller, Jonathan D. Mohnkern, Robert S. Gardner, Louis T. Dang, Julie M. Ziobro, Richard J. H. Wojcikiewicz, Nathan R. Tucker and David S. Auerbach
    Citation: Journal of Translational Medicine 2025 23:446
  8. The intimate correlation between cardiovascular diseases and other organ pathologies, such as metabolic and kidney diseases, underscores the intricate interactions among these organs. Understanding inter-organ...

    Authors: Baoqiang Ni, Lingqun Ye, Yan Zhang, Shijun Hu and Wei Lei
    Citation: Journal of Translational Medicine 2025 23:380
  9. Patients with primary aldosteronism (PA) are at a high risk of cardiovascular diseases (CVD) and metabolic syndrome. Notable inflammatory and fibrotic changes and differential microRNA (miRNA) expression profi...

    Authors: Xuelin Li, Min Luo, Yanmei Zeng, Renyi Zhang, Xiaochun Lin, Yuejun Du, Wei Zhao, Qijian Feng, Minghai Wu, Jin Zhang, Lei Guo, Peili Wu, Chuyi Yang, Feifei Cai, Yuan Wang, Yuxuan Hu…
    Citation: Journal of Translational Medicine 2025 23:345
  10. Dysregulation of histone methylation-based epigenetic mechanisms leads to either transient or long-lasting transcriptomic alterations in vascular and immune cells with important consequences on atherosclerotic...

    Authors: Simona-Adriana Manea, Mihaela-Loredana Vlad, Alexandra-Gela Lazar, Horia Muresian, Maya Simionescu and Adrian Manea
    Citation: Journal of Translational Medicine 2025 23:339
  11. In developed nations, myocardial infarction (MI) is one of the main causes of morbidity and mortality, resulting in a significant economic burden and becoming a global public health problem. C1q/tumor necrosis...

    Authors: Yanzhen Tan, Hong Li, Guojie Cao, Jialin Xin, Dongxu Yan, Yingying Liu, Panpan Li, Yuxi Zhang, Lei Shi, Bing Zhang, Wei Yi and Yang Sun
    Citation: Journal of Translational Medicine 2025 23:300
  12. Cardiomyopathies are a heterogeneous group of disorders that can lead to fulminant heart failure and sudden cardiac death. In recent years, the prevalence of all types of cardiomyopathies has shown an upward t...

    Authors: Elahe Radmehr, Niloufar Yazdanpanah and Nima Rezaei
    Citation: Journal of Translational Medicine 2025 23:249
  13. Prenatal development of autonomic innervation of sinus venosus-related structures might be related to atrial arrhythmias later in life. Most of the pioneering studies providing embryological background are con...

    Authors: Fleur Zwanenburg, Thomas A. Bos, Arend D. J. Ten Harkel, Monique C. Haak, Nathan D. Hahurij, Robert E. Poelmann, Conny J. van Munsteren, Lambertus J. Wisse, Nico A. Blom, Marco C. DeRuiter and Monique R. M. Jongbloed
    Citation: Journal of Translational Medicine 2025 23:73
  14. Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Infiltration and alterations in non-cardiomyocytes of the human heart involve crucially in the occurrence of DCM and associated i...

    Authors: Siyu He, Chunyu Li, Mingxin Lu, Fang Lin, Sangyu Hu, Junfang Zhang, Luying Peng and Li Li
    Citation: Journal of Translational Medicine 2025 23:17
  15. Ischemic cardiomyopathy, characterized by coronary artery atherosclerosis, impairs the myocardial tissue. Coronary artery bypass grafting (CABG) is commonly used to revascularize affected areas and improve pat...

    Authors: Takuji Kawamura, Daisuke Yoshioka, Ai Kawamura, Yusuke Misumi, Takura Taguchi, Daisuke Mori, Shunsuke Saito, Takashi Yamauchi, Hiroki Hata and Shigeru Miyagawa
    Citation: Journal of Translational Medicine 2024 22:1091
  16. Right ventricular volume overload (RVVO) is one of the most important hemodynamic characteristics in children with congenital heart disease (CHD) and heart failure, and cardiomyocyte (CM) proliferation is one ...

    Authors: Chunxia Zhou, Yuqing Hu, Zhuoya Dong, Zheng Wang, Sixie Zheng, Debao Li, Yingying Xiao, Dian Chen, Hao Chen, Sijuan Sun, Lincai Ye and Haibo Zhang
    Citation: Journal of Translational Medicine 2024 22:1075
  17. The use of light to control the activity of living cells is a promising approach in cardiac research due to its unparalleled spatio-temporal selectivity and minimal invasiveness. Ziapin2, a newly synthesized a...

    Authors: Chiara Florindi, Vito Vurro, Paola Moretti, Chiara Bertarelli, Antonio Zaza, Guglielmo Lanzani and Francesco Lodola
    Citation: Journal of Translational Medicine 2024 22:1068
  18. The role of the complement inhibitory proteins CD46 and CD59 in the immune response to an acute coronary syndrome (ACS) is unknown. We investigated the relationships between the shedding of CD46 and CD59 into ...

    Authors: Baojun Zhong, Ben King, Homa Waziri, Troels Yndigegn, Daniel Engelbertsen, Harry Björkbacka, Jan Nilsson, Isabel Goncalves, Anna M. Blom and Alexandru Schiopu
    Citation: Journal of Translational Medicine 2024 22:1011
  19. Vasculogenic therapies explored for the treatment of peripheral artery disease (PAD) have encountered minimal success in clinical trials. Addressing this, B55α, an isoform of protein phosphatase 2A (PP2A), eme...

    Authors: Adela García-Martín, María E. Prados, Isabel Lastres-Cubillo, Francisco J. Ponce-Diaz, Laura Cerero, Martin Garrido-Rodríguez, Carmen Navarrete, Rafael Pineda, Ana B. Rodríguez, Ignacio Muñoz, Javier Moya, Antonella Medeot, José A. Moreno, Antonio Chacón, José García-Revillo and Eduardo Muñoz
    Citation: Journal of Translational Medicine 2024 22:1003
  20. Hyperuricemia is independently associated with a poor prognosis in patients with myocardial infarction (MI). Furthermore, MI induces activation of the repair response in local fibroblasts, resulting in extrace...

    Authors: Zehao Zhuang, Ao Liu, Jinghong Zhang, Shuangjian Han, Lu Tang, Tingting Yu, Yiping Shi, Hui Li, Heng Yang, Peiyuan Bai and Yanhua Tang
    Citation: Journal of Translational Medicine 2024 22:983
  21. In mouse models of atherosclerosis, knockout of the PLA2G2A gene has been shown to reduce the volume of atherosclerotic plaques. Clinical trials have demonstrated the potential of using the sPLA2 inhibitor Var...

    Authors: Xin Wang, Shen Li, Chen Liu, Jiawei Zhao, Gangfeng Ren, Feng Zhang, Xuyang Liu, Shuang Cao, Yuming Xu and Zongping Xia
    Citation: Journal of Translational Medicine 2024 22:967
  22. Lower limb arterial occlusive disease is treated with intraluminal devices, such as paclitaxel (PTX)-coated balloons (PCBs); however, post-procedural restenosis remains a significant challenge. NLRP3 activatio...

    Authors: Qinghui Kan, Zhanli Peng, Kangjie Wang, Tang Deng, Zhihao Zhou, Ridong Wu, Chen Yao and Rui Wang
    Citation: Journal of Translational Medicine 2024 22:871
  23. Doxorubicin is an important anticancer drug, however, elicits dose-dependently cardiomyopathy. Given its mode of action, i.e. topoisomerase inhibition and DNA damage, we investigated genetic events associated ...

    Authors: Jürgen Borlak, Yari Ciribilli, Alessandra Bisio, Saravanakumar Selvaraj, Alberto Inga, Jung-Hwa Oh and Reinhard Spanel
    Citation: Journal of Translational Medicine 2024 22:845
  24. The prevalence of vascular calcification (VC) in chronic kidney disease (CKD) patients remains substantial, but currently, there are no effective pharmaceutical therapies available. BRCA1/BRCA2-containing comp...

    Authors: Yalan Li, Xiaoyue Chen, Yiqing Xiong, Xueqiang Xu, Caidie Xie, Min Min, Dongmei Liang, Cheng Chen and Huijuan Mao
    Citation: Journal of Translational Medicine 2024 22:820
  25. We aimed to compare the changes in blood metabolomes and cardiac parameters following doxorubicin treatment in HER2-positive and HER2-negative breast cancer patients. Additionally, the potential roles of chang...

    Authors: Chanisa Thonusin, Nichanan Osataphan, Krit Leemasawat, Wichwara Nawara, Sirawit Sriwichaiin, Siriporn Supakham, Siriluck Gunaparn, Nattayaporn Apaijai, Areewan Somwangprasert, Arintaya Phrommintikul, Siriporn C. Chattipakorn and Nipon Chattipakorn
    Citation: Journal of Translational Medicine 2024 22:398
  26. Maladaptive cardiac hypertrophy contributes to the development of heart failure (HF). The oxidoreductase Selenoprotein T (SELENOT) emerged as a key regulator during rat cardiogenesis and acute cardiac protecti...

    Authors: Anna De Bartolo, Teresa Pasqua, Naomi Romeo, Vittoria Rago, Ida Perrotta, Francesca Giordano, Maria Concetta Granieri, Alessandro Marrone, Rosa Mazza, Maria Carmela Cerra, Benjamin Lefranc, Jérôme Leprince, Youssef Anouar, Tommaso Angelone and Carmine Rocca
    Citation: Journal of Translational Medicine 2024 22:375
  27. Authors: Giuseppina Caiazzo, Rosa Redenta De Simone, Emanuele Monda, Ferdinando Barretta, Fabiana Uomo, Cristina Mazzaccara, Matteo Megna, Limongelli Giuseppe and Giulia Frisso
    Citation: Journal of Translational Medicine 2024 22:357
  28. Long QT syndrome type 7 (Andersen–Tawil syndrome, ATS), which is caused by KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal malformations. The development, differenti...

    Authors: Peipei Chen, Junyu Long, Tianrui Hua, Zhifa Zheng, Ying Xiao, Lianfeng Chen, Kang Yu, Wei Wu and Shuyang Zhang
    Citation: Journal of Translational Medicine 2024 22:307
  29. Lactate is traditionally recognized as a by-product of anaerobic metabolism. However, lactate is a preferred oxidative substrate for stressed myocardium. Exogenous lactate infusion increases cardiac output (CO...

    Authors: Oskar Kjærgaard Hørsdal, Niels Moeslund, Kristoffer Berg-Hansen, Roni Nielsen, Niels Møller, Hans Eiskjær, Henrik Wiggers and Nigopan Gopalasingam
    Citation: Journal of Translational Medicine 2024 22:285
  30. Amino acids (AAs) are one of the primary metabolic substrates for cardiac work. The correlation between AAs and both atrial fibrillation (AF) and aging has been documented. However, the relationship between AA...

    Authors: Yunying Huang, Qiuzhen Lin, Yong Zhou, Jiayi Zhu, Yingxu Ma, Keke Wu, Zuodong Ning, Zixi Zhang, Na Liu, Mohan Li, Yaozhong Liu, Tao Tu and Qiming Liu
    Citation: Journal of Translational Medicine 2024 22:259
  31. Currently, noninvasive imaging techniques and circulating biomarkers are still insufficient to accurately assess carotid plaque stability, and an in-depth understanding of the molecular mechanisms that contrib...

    Authors: Zhichao Lai, Chaonan Wang, Xiaoyan Liu, Haidan Sun, Zhengguang Guo, Jiang Shao, Kang Li, Junye Chen, Jiaxian Wang, Xiangling Lei, Keqiang Shu, Yuyao Feng, Deqiang Kong, Wei Sun and Bao Liu
    Citation: Journal of Translational Medicine 2024 22:247
  32. Prior evidence demonstrated that Regulator of G protein Signaling 6 (RGS6) translocates to the nucleolus in response to cytotoxic stress though the functional significance of this phenomenon remains unknown.

    Authors: Abhishek Singh Sengar, Manish Kumar, Chetna Rai, Sreemoyee Chakraborti, Dinesh Kumar, Pranesh Kumar, Sukhes Mukherjee, Kausik Mondal, Adele Stewart and Biswanath Maity
    Citation: Journal of Translational Medicine 2024 22:204
  33. Heart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of heart failure cases. The molecular mechanisms by which HFpEF leads to impaired diastolic function of the heart have not ...

    Authors: Yixiao Xiong, Xin Liu, Ling Jiang, Tao Hao, Yanyan Wang and Tao Li
    Citation: Journal of Translational Medicine 2024 22:199
  34. Coronary artery bypass graft (CABG) is generally used to treat complex coronary artery disease. Treatment success is affected by neointimal hyperplasia (NIH) of graft and anastomotic sites. Although sirolimus ...

    Authors: Ji-yeon Ryu, Eui Hwa Jang, JiYong Lee, Jung-Hwan Kim and Young-Nam Youn
    Citation: Journal of Translational Medicine 2024 22:166
  35. Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary disease characterized by complement dependent and proinflammatory activation of macrophages. However, effective treatment for complement activa...

    Authors: Lei Dai, Yu Chen, Jinhua Wu, Zhen He, Yueqi Zhang, Wenjun Zhang, Yang Xie, Hesong Zeng and Xiaodan Zhong
    Citation: Journal of Translational Medicine 2024 22:164
  36. Cardiac fibroblast activation protein (FAP) has an emerging role in heart failure (HF). A paradoxical reduction in its levels in pathological conditions associated with acute processes has been observed. We ai...

    Authors: Marta Delgado-Arija, Patricia Genovés, Lorena Pérez-Carrillo, Irene González-Torrent, Isaac Giménez-Escamilla, Luis Martínez-Dolz, Manuel Portolés, Estefanía Tarazón and Esther Roselló-Lletí
    Citation: Journal of Translational Medicine 2024 22:124
  37. The sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA2a) depression substantially contributes to diastolic dysfunction in heart failure (HF), suggesting that SERCA2a stimulation may be a mechanism-based HF therapy. ...

    Authors: Martina Arici, Shih-Che Hsu, Mara Ferrandi, Paolo Barassi, Carlotta Ronchi, Eleonora Torre, Andrea Luraghi, Gwo-Jyh Chang, Patrizia Ferrari, Giuseppe Bianchi, Francesco Peri, Antonio Zaza and Marcella Rocchetti
    Citation: Journal of Translational Medicine 2024 22:77
  38. Long Intergenic noncoding RNA predicting CARdiac remodeling (LIPCAR) is a long noncoding RNA identified in plasma of patients after myocardial infarction (MI) to be associated with left ventricle remodeling (L...

    Authors: Annie Turkieh, Olivia Beseme, Ouriel Saura, Henri Charrier, Jean-Baptiste Michel, Philippe Amouyel, Thomas Thum, Christophe Bauters and Florence Pinet
    Citation: Journal of Translational Medicine 2024 22:31
  39. Pulmonary hypertension (PH), an infrequent disease, is characterized by excessive pulmonary vascular remodeling and proliferation of pulmonary artery smooth muscle cells (PASMCs). However, its underlying molec...

    Authors: Yingli Liu, Li Zhu, Yue Ming, Zhuhua Wu, Lili Zhang, Qi Chen and Yong Qi
    Citation: Journal of Translational Medicine 2023 21:821
  40. Heart transplantation (HTX) is the standard treatment for end-stage heart failure. However, reperfusion following an ischemic period can contribute to myocardial injury. Neutrophil infiltration, along with the...

    Authors: Baoer Liu, Brice Korkmaz, Patricia Kraft, Tobias Mayer, Alex A. Sayour, Marc A. Grundl, Roxane Domain, Matthias Karck, Gábor Szabó and Sevil Korkmaz-Icöz
    Citation: Journal of Translational Medicine 2023 21:799
  41. Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have revealed diverse aetiologies. Among them, familial DCM is th...

    Authors: Chia Yee Tan, Pui Shi Chan, Hansen Tan, Sung Wei Tan, Chang Jie Mick Lee, Jiong-Wei Wang, Shu Ye, Hendrikje Werner, Ying Jie Loh, Yin Loon Lee, Matthew Ackers-Johnson, Roger S. Y. Foo and Jianming Jiang
    Citation: Journal of Translational Medicine 2023 21:690
  42. Atherosclerosis is a chronic inflammatory process induced by the influx and entrapment of excess lipoproteins into the intima media of arteries. Previously, our lab demonstrated that systemic PTP1B inhibition ...

    Authors: Helk Oliver, Dekeryte Ruta, Dawn Thompson, Sarah Kamli-Salino, Sam Philip, Heather M. Wilson, Nimesh Mody and Mirela Delibegovic
    Citation: Journal of Translational Medicine 2023 21:715
  43. Heart diseases are among the leading causes of death worldwide, many of which lead to pathological cardiomyocyte hypertrophy and capillary rarefaction in both patients and animal models, the quantification of ...

    Authors: Patrick Droste, Dickson W. L. Wong, Mathias Hohl, Saskia von Stillfried, Barbara M. Klinkhammer and Peter Boor
    Citation: Journal of Translational Medicine 2023 21:666
  44. Inflammation in cardiac adipose tissue (AT) is associated with atherosclerosis. We investigated whether the epicardial-, pericardial and pre-sternal subcutaneous AT (EAT, PAT and SAT) expression of Sirtuin1 (S...

    Authors: Trine Baur Opstad, Bianca Papotti, Sissel Åkra, Charlotte Holst Hansen, Bjørn Braathen, Theis Tønnessen, Svein Solheim and Ingebjørg Seljeflot
    Citation: Journal of Translational Medicine 2023 21:644
  45. Vibrational spectroscopy can be a valuable tool to monitor the markers of cardiovascular diseases. In the present work, we explored the vibrational spectroscopy characteristics of the cardiac tissue in an expe...

    Authors: Leonardo Pioppi, Reza Parvan, Alan Samrend, Gustavo Jose Justo Silva, Marco Paolantoni, Paola Sassi and Alessandro Cataliotti
    Citation: Journal of Translational Medicine 2023 21:617
  46. Long-chain acyl-carnitines (ACs) are potential arrhythmogenic metabolites. Their role in atrial fibrillation (AF) remains incompletely understood. Using a systems medicine approach, we assessed the contributio...

    Authors: Julia Krause, Alexander Nickel, Alexandra Madsen, Hamish M. Aitken-Buck, A. M. Stella Stoter, Jessica Schrapers, Francisco Ojeda, Kira Geiger, Melanie Kern, Michael Kohlhaas, Edoardo Bertero, Patrick Hofmockel, Florian Hübner, Ines Assum, Matthias Heinig, Christian Müller…
    Citation: Journal of Translational Medicine 2023 21:566
  47. Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis (AS), and myocardial infarct...

    Authors: Qian Yan, Shasha Liu, Yang Sun, Chen Chen, Songwei Yang, Meiyu Lin, Junpeng Long, Jiao Yao, Yuting Lin, Fan Yi, Lei Meng, Yong Tan, Qidi Ai, Naihong Chen and Yantao Yang
    Citation: Journal of Translational Medicine 2023 21:519
  48. Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart failure and even death. Multiple bi...

    Authors: Jaydev Dave, Vineeta Jagana, Radoslav Janostiak and Malik Bisserier
    Citation: Journal of Translational Medicine 2023 21:477
  49. Dilated cardiomyopathy (DCM) is one of the most frequent causes of heart failure and heart transplantation (HTx). The genetic basis of DCM among patients undergoing HTx remains to be further studied. This stud...

    Authors: Hong Lian, Shen Song, Wenzheng Chen, Anteng Shi, Haobin Jiang and Shengshou Hu
    Citation: Journal of Translational Medicine 2023 21:476

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