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Emerging Therapeutics

Section edited by Gennaro Ciliberto

© Parilov / stock.adobe.comThe Emerging Therapeutics section is dedicated to the wave of emerging therapeutics arising from the intense research efforts and therapeutic breakthroughs based on recent scientific and technological developments. 

The section is interested in original papers, reviews and perspectives on the advancements in the field, including genetic vaccines, monoclonal antibodies, CAR-Ts, gene therapy with viral vectors, clinical applications of CRISPR/CAS9 gene editing, microbiota-modulating approaches, ‘omics approaches, emerging therapeutics from the development of new technologies for drug development, and discovery of new intervention targets and the possibility for new drug combinations.

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  1. The molecular landscape of lung neuroendocrine neoplasms is still poorly characterized, making it difficult to develop a molecular classification and personalized therapeutic approaches. Significant clinical h...

    Authors: Giulia Pecora, Camilla Mancini, Rossella Mazzilli, Virginia Zamponi, Stefano Telese, Stefano Scalera, Marcello Maugeri-Saccà, Ludovica Ciuffreda, Francesca De Nicola, Maurizio Fanciulli, Anna La Salvia, Massimiliano Mancini, Andrea Vecchione, Alessandra Siciliani, Mohsen Ibrahim, Diana Bellavia…
    Citation: Journal of Translational Medicine 2025 23:538
    Content type: Research Published on:

  2. Protein Tyrosine Phosphatase Receptor Type Kappa (PTPRK) is a membrane-bound tyrosine phosphatase encoded by the frequently deleted region of chromosome 6q, which plays a crucial role in regulating cell signaling...

    Authors: Chen Zheng, Ting Liu, An Qi Wang, Xing An Chen, Rong Zhe Zhang, Xuan Chao Wang, Chao Yue Lv, Ru Lu Pan, Ou Chen Wang and Xin-Cheng Lu
    Citation: Journal of Translational Medicine 2025 23:534
    Content type: Review Published on:

  3. The delivery of macromolecules through dermal and transdermal routes presents both significant challenges and transformative opportunities in therapeutic applications. This review highlights the most recent ad...

    Authors: Medha Bhat, Abhay Tharmatt, Samarth Bhargava, Tushar Kumeria, Amit Mishra, Anupama Mittal and Deepak Chitkara
    Citation: Journal of Translational Medicine 2025 23:513
    Content type: Review Published on:

  4. Tumor immunotherapy is one of the most promising strategies in cancer treatment. Specifically, intraperitoneal immunotherapy has emerged as a novel approach for dealing with abdominal metastases. Previously, w...

    Authors: Qi Wang, Yi Mei, Wenmei Rao, Sen Hong, Aoxing Chen, Yang Yang and Qin Liu
    Citation: Journal of Translational Medicine 2025 23:509
    Content type: Research Published on:

  5. Peptide-based therapeutics for melanoma have received increasing attention in medical research. However, the local delivery of such therapeutics poses unique challenges. Cell-penetrating peptides (CPPs) with t...

    Authors: Zheng Zhao, Zi-Qian Li, Ying-Bin Huang, Meng-meng Liu, Fei Cao, Guo-Long Bu, Peng-Fei Xu, Qi Fang, Zhu-Long Hu, Di Wu, Guo-Kai Feng and Xue-Kui Liu
    Citation: Journal of Translational Medicine 2025 23:495
    Content type: Research Published on:

  6. Despite the prevalence of non-small cell lung cancer (NSCLC) is high, the limited early detection and management of these tumors are restricted since there is an absence of reliable and precise diagnostic biom...

    Authors: Hongyuan Yin, Jiayi Shi, Shaoling Li, Qianhui You, Huici Zhu, Chinying Koo, Baonian Liu, Likun Hou and Chunyan Wu
    Citation: Journal of Translational Medicine 2025 23:490
    Content type: Review Published on:

  7. Dual-specific phosphatase-8 (DUSP8), identified as the first gene in a genome-wide association study (GWAS), is implicated in cellular oxidative stress, proliferation, apoptosis, and drug resistance through it...

    Authors: Tingping Cao, Quanling Zhou, Fujun Li, Mingyue Wang, Ming Zhang, Xiaohui Li, Hailong Zhao and Ya Zhou
    Citation: Journal of Translational Medicine 2025 23:485
    Content type: Review Published on:

  8. Melanoma is a highly aggressive form of skin cancer. Despite significant advances in targeted therapies and immunotherapeutic approaches, some patients still have poor response rates, making a deeper understan...

    Authors: Yongyi Xie, Ruoqi Wang, Mingyuan Xu, Jiashe Chen, Wei Tan, Yanbin Chen, Yun Bai, Nanhui Wu, Fei Wu, Xiaoxiang Xu, Xin Ma and Yeqiang Liu
    Citation: Journal of Translational Medicine 2025 23:470
    Content type: Research Published on:

  9. The ribosomal DNA (rDNA) plays a vital role in regulating protein synthesis by ribosome biogenesis, essential for maintaining cellular growth, metabolism, and more. Cancer cells show a high dependence on ribos...

    Authors: Hong-Xia Li, Yi-Meng He, Jing Fei, Man Guo, Chen Zeng, Pi-Jun Yan, Yong Xu, Gang Qin and Fang-Yuan Teng
    Citation: Journal of Translational Medicine 2025 23:457
    Content type: Review Published on:

  10. Endometrial cancer ranks among the most common gynecological cancers, with increasing rates of incidence and death. Cold atmospheric plasma (CAP) has become a promising novel therapeutic approach for cancer tr...

    Authors: Jinlin Liu, Yang Li, Ruonan Ma, Youming Chen, Jinyang Wang, Lindong Zhang, Baojin Wang, Zidi Zhang, Lili Huang, Hongyan Zhang, Junhu Wan and Hongyang Liu
    Citation: Journal of Translational Medicine 2025 23:442
    Content type: Research Published on:

  11. Breast cancer is one of the most prevalent malignant tumors among women and ranks as the second leading cause of cancer-related deaths in females, primarily due to delays in diagnosis and shortcomings in treat...

    Authors: Yun Hong, Jun He, Dan Deng, Qinyue Liu, Xuyu Zu and Yingying Shen
    Citation: Journal of Translational Medicine 2025 23:439
    Content type: Review Published on:

  12. Extracellular vesicles (EVs) produced in the tumor microenvironment in response to chemotherapy promote chemotherapy-resistant phenotypes. However, the role of EVs proteins induced by gastric cancer (GC) cell ...

    Authors: Yuhan Liao, Xinhua Chen, Hao Xu, Yunfei Zhi, Xinghua Zhuo, Jiang Yu and Liang Zhao
    Citation: Journal of Translational Medicine 2025 23:320
    Content type: Research Published on:

  13. Endothelial dysfunction is a hallmark feature of cardiovascular disease (CVD), yet the underlying mechanisms are still poorly understood. This has impeded the development of effective therapies, particularly f...

    Authors: Sahar Ghorbanpour, Siân Peta Cartland, Hao Chen, Sanchit Seth, Rupert C. Ecker, Claire Richards, Dunja Aksentijevic, Matthew P. Padula, Louise Cole, Majid Ebrahimi Warkiani, Mary Meltem Kavurma and Lana McClements
    Citation: Journal of Translational Medicine 2025 23:309
    Content type: Research Published on:

  14. Emerging evidence has confirmed the inextricable connection between N4-acetylcytidine (ac4C) mRNA modification and the clinical characteristics of malignancies. Nonetheless, it is uncertain whether and how ac4...

    Authors: Jianlan Liu, Pengpeng Zhang, Chaoqin Wu, Binlin Luo, Xiaojian Cao and Jian Tang
    Citation: Journal of Translational Medicine 2025 23:287
    Content type: Research Published on:

  15. Neisseria gonorrhoeae is an escalating global health threat due to increasing antimicrobial resistance. The emergence of multidrug-resistant (MDR) strains necessitates alternative prevention strategies. This stud...

    Authors: Narjes Noori Goodarzi, Seyed Mahmoud Barzi, Soheila Ajdary, Mohsen Chiani, Mir Saeed Yekaninejad, Farzad Badmasti and Mohammad Reza Pourmand
    Citation: Journal of Translational Medicine 2025 23:261
    Content type: Research Published on:

  16. Pentamidine (PTM) is an aromatic diamidine administered for infectious diseases, e.g. sleeping sickness, malaria, and Pneumocystis jirovecii pneumonia. Due to similarities of cellular mechanisms between human cel...

    Authors: Nima Rastegar-Pouyani, Mohammad Amin Farzin, Jaber Zafari, Mohadeseh Haji Abdolvahab and Shokoufeh Hassani
    Citation: Journal of Translational Medicine 2025 23:258
    Content type: Review Published on:

  17. Progression to castration resistance is the leading cause of death in prostate cancer patients. Long non-coding RNAs (lncRNAs) have recently become a focal point in the regulation of cancer development. Howeve...

    Authors: Yingying Wu, Shaojie Cheng, Ting Zhang, Leilei Wang, Ting Li, Yongbo Zheng, Guo Yang, Xiaohou Wu, Chunli Luo, Tingmei Chen and Liping Ou
    Citation: Journal of Translational Medicine 2025 23:255
    Content type: Research Published on:

  18. Transmembrane protein 52B (TMEM52B) is a novel gene expressed widely in various normal human tissues; however, the biological function of TMEM52B in cancer remains largely unknown. Previously, we demonstrated ...

    Authors: Yunhee Lee, Dongjoon Ko, Junghwa Yoon and Semi Kim
    Citation: Journal of Translational Medicine 2025 23:146
    Content type: Research Published on:

  19. CircRNAs are closely related to ferroptosis in gastric cancer cells; however, the mechanism by which circRNAs regulate ferroptosis in gastric carcinogenesis remains unknown. CircRNA-encoded novel peptides are ...

    Authors: Song Wang, Chengwei Wu, Jiawei Wang, Feng Yuan, Yinfen Hou, Tingting Cao, Lishuai Xu, Long Qian, Yabin Xia, Li Xu, Ailiang Zeng, Xiaoming Wang, Luman Wang and Xiaoxu Huang
    Citation: Journal of Translational Medicine 2025 23:250
    Content type: Research Published on:

  21. Co-stimulatory molecules are imperative for CD8+ T cells to eliminate target cell and maintain sustained cytotoxicity. Despite an advanced understanding of the co-stimulatory molecules deficiency that results in ...

    Authors: Hanyi Zeng, Jiaping Yu, Haijian Wang, Mengying Shen, Xuejing Zou, Ziyong Zhang and Li Liu
    Citation: Journal of Translational Medicine 2025 23:225
    Content type: Research Published on:

  22. Immune checkpoint inhibitors (ICIs) are emerging promising agents for the treatment of patients with esophageal squamous cell carcinoma (ESCC), however, there are only a small proportion respond to ICI therapy...

    Authors: Xinxin Cheng, Huihui Zhao, Zhangwang Li, Liping Yan, Qingjie Min, Qingnan Wu and Qimin Zhan
    Citation: Journal of Translational Medicine 2025 23:197
    Content type: Research Published on:

  23. Tyroservatide (YSV), a bioactive tripeptide, holds potential as an anti-tumor agent. However, its specific effects on oral squamous cell carcinoma (OSCC) have not been elucidated. This study aims to investigat...

    Authors: Lin Qiu, Qian Gao, Yiheng Liao, Xinxin Li and Cuiying Li
    Citation: Journal of Translational Medicine 2025 23:145
    Content type: Research Published on:

  24. Acute pancreatitis (AP) presents a significant clinical challenge with limited therapeutic options. The complex etiology and pathophysiology of AP emphasize the need for innovative treatments. This study explo...

    Authors: Amaya Lopez-Pascual, Eva Santamaria, Nuria Ardaiz, Iker Uriarte, Tiffany Palmer, Anne-Renee Graham, Celia Gomar, Roberto C. Barbero, M. Ujue Latasa, Maria Arechederra, Jesus M. Urman, Carmen Berasain, Antonio Fontanellas, Carlos L. del Rio, Maite G. Fernandez-Barrena, Paolo G.V. Martini…
    Citation: Journal of Translational Medicine 2025 23:122
    Content type: Research Published on:

  25. The high mortality rate of metastatic colorectal cancer (CRC) is primarily attributed to resistance to chemotherapy, where cancer stem cells (CSCs) play a crucial role. Deubiquitinating enzymes are essential r...

    Authors: Fengtian Li, Yi Zhou, Xinyue Lin, Yaxin Zhang, Qingyong Hu, Enen Zhao, Huali Li, Xingyan Pan, Feng Shu, Kun Zhang, Chengmei Huang, Na Tang and Wenting Liao
    Citation: Journal of Translational Medicine 2025 23:114
    Content type: Research Published on:

  26. The sustained activation of androgen receptor splice variant-7 (AR-V7) is a key factor in the resistance of castration-resistant prostate cancer (CRPC) to second-generation anti-androgens such as enzalutamide ...

    Authors: Xiannan Meng, Qingxuan Wu, Chengsong Cao, Wendong Yang, Sufang Chu, Hongjun Guo, Suhua Qi and Jin Bai
    Citation: Journal of Translational Medicine 2025 23:108
    Content type: Research Published on:

  27. Super enhancers are a unique class of enhancers that possess a distinct structure and mechanism, which enable them to exhibit stronger gene transcription regulatory function than classical enhancers, thereby r...

    Authors: Yumeng Ji, Baixue Li, Rongjin Lin, Jing Yuan, Yang Han, Yuping Du and Yang Zhao
    Citation: Journal of Translational Medicine 2025 23:98
    Content type: Review Published on:

  28. PRDX2 is significantly expressed in various cancers and is associated with the proliferation of tumor cells. Nonetheless, the precise mechanism of PRDX2 in tumor immunity remains incompletely understood. This ...

    Authors: Yunjia Dong, Anqi Cheng, Jiawei Zhou, Jianqiang Guo, Yafeng Liu, Xuan Li, Maoqian Chen, Dong Hu and Jing Wu
    Citation: Journal of Translational Medicine 2025 23:81
    Content type: Research Published on:

  29. This review seeks to elucidate the therapeutic potential of tumor necrosis factor receptor 1 (TNFR1) and enhance our comprehension of its role in disease mechanisms. As a critical cell-surface receptor, TNFR1 ...

    Authors: Yingying Li, Ruiwei Ye, Haorui Dai, Jiayi Lin, Yue Cheng, Yonghong Zhou and Yiming Lu
    Citation: Journal of Translational Medicine 2025 23:71
    Content type: Review Published on:

  30. Agonistic monoclonal antibodies targeting 4-1BB/CD137 have shown preclinical promise, but their clinical development has been limited by severe liver toxicity or limited efficacy. Therefore, a safe and efficie...

    Authors: Da-yan Zhang, Zhi-hua Zhang, Wen-ting Liu, Wei-ming Zhou, Peng-fei Zhou, Juan-juan Wei, Xue-jing Dai, Xiao-li Zeng, Yu-qiong Zhou, Han-wang Li, Heng Zhang, Ao-lin Shen, Lian-sheng Cheng, Guo-dong Shen and Yi-fu He
    Citation: Journal of Translational Medicine 2025 23:53
    Content type: Research Published on:

  31. Tumor-associated macrophages (TAMs) are pivotal immune cells within the tumor microenvironment (TME), exhibiting dual roles across various cancer types. Depending on the context, TAMs can either suppress tumor...

    Authors: Kaiting Chen, Xiaochen Li, Shuyi Dong, Yu Guo, Ziyin Luo, Shi-Min Zhuang, Jie Liu, Tianrun Liu, Jing Liao and Weiping Wen
    Citation: Journal of Translational Medicine 2025 23:27
    Content type: Research Published on:

  32. Glioblastoma (GBM) is a rare brain cancer with an exceptionally high mortality rate, which illustrates the pressing demand for more effective therapeutic options. Despite considerable research efforts on GBM, ...

    Authors: Shixue Sun, Zeenat Shyr, Kathleen McDaniel, Yuhong Fang, Dingyin Tao, Catherine Z. Chen, Wei Zheng and Qian Zhu
    Citation: Journal of Translational Medicine 2025 23:25
    Content type: Research Published on:

  33. The overall prognosis of patients with esophageal cancer (EC) is extremely poor. There is an urgent need to develop innovative therapeutic strategies. This study will investigate the anti-cancer effects of exo...

    Authors: Yanmei Yu, Bingjie Jin, Ruzhen Jia, Lei Shi, Yong Chen, Jian Ge and Changqin Xu
    Citation: Journal of Translational Medicine 2024 22:1166
    Content type: Research Published on:

  34. Renal CD8+ tissue-resident memory T (TRM) cells display prolonged survival and activity in lupus nephritis (LN), exacerbating renal pathology. NLRP3 regulates the T cell response. This study explored the impact o...

    Authors: Yimei Lai, Lili Zhuang, Jieying Zhu, Shuang Wang, Chaohuan Guo, Binfeng Chen, Jin Li, Jia Shi, Mengyuan Li, Niansheng Yang and Mianjing Zhou
    Citation: Journal of Translational Medicine 2024 22:1139
    Content type: Research Published on:

  35. Cancer has become one of the major diseases threatening human health in the twenty-first century due to its incurability. In 2022, new cases of esophageal and gastrointestinal cancers accounted for 17.1% of al...

    Authors: Xiaochao Ma, Tianyu Lu, Yue Yang, Da Qin, Ze Tang, Youbin Cui and Rui Wang
    Citation: Journal of Translational Medicine 2024 22:1120
    Content type: Review Published on:

  37. Despite the proven inhibitory effects of drugs targeting vascular endothelial growth factor receptor 2 (VEGFR2) on solid tumors, including non-small cell lung cancer (NSCLC), the development of anti-NSCLC drug...

    Authors: Zixiao Wang, Lili Sun, Yu Xu, Jing Huang, Fang Yang and Yu Chang
    Citation: Journal of Translational Medicine 2024 22:1097
    Content type: Research Published on:

  38. Sulfotransferase family 2B member 1 (SULT2B1) is involved in regulating cell proliferation, migration and metabolism. However, there is still dispute regarding whether SULT2B1 acts as an oncogene or a suppress...

    Authors: Jianxing Ma, Fengyao Sun, Wen Li, Ruihang Du, Mingchan Liu, Qiuya Wei, Boxiong Kang, Siyuan Yan and Chen Wang
    Citation: Journal of Translational Medicine 2024 22:1093
    Content type: Research Published on:

  39. Extracellular vesicles (EVs) are phospholipid bilayer-enclosed biological particles that are secreted by almost all living cells including animals, plants, and microorganisms. Chinese herbal medicines (CHM) ha...

    Authors: Jinying Zhang, Shuo Tian, Lin Guo, Hui Zhao, Zhiguo Mao and Mingsan Miao
    Citation: Journal of Translational Medicine 2024 22:1059
    Content type: Review Published on:

  40. The novel nanomaterials PNA-TN (PN) and PNA-TN-Dox (PND) have been shown to have strong inhibitory effects on breast cancer; however, it is unclear whether PN and PND have anti-head and neck squamous cell carc...

    Authors: Qian Lin, Hui-Min Liu, Li-Zhi Wu, Dong-Dong Yu, Cheng-Yu Hua, You Zou, Wo-Er Jiao, Xiang-Pan Li and Shi-Ming Chen
    Citation: Journal of Translational Medicine 2024 22:1043
    Content type: Research Published on:

  41. Since the discovery of Fe3O4 nanoparticles with enzyme-like activity in 2007, nanozymes have emerged as a promising class of catalysts, offering advantages such as high catalytic efficiency, low cost, mild rea...

    Authors: Xinqiao Li, Jinpeng Hu, Qi Zhao, Weifeng Yao, Zhitao Jing and Zhizhong Jin
    Citation: Journal of Translational Medicine 2024 22:1033
    Content type: Review Published on:

  42. ENO1, also called 2-phospho-D-glycerate hydrolase in cellular glycolysis, is an enzyme that converts 2-phosphoglycerate to phosphoenolpyruvate and plays an important role in the Warburg effect. In various tumo...

    Authors: Yafei Li, Lu Liu and Bo Li
    Citation: Journal of Translational Medicine 2024 22:1025
    Content type: Review Published on:

  43. Cholangiocarcinoma (CCA) is an aggressive malignancy with limited treatment options and poor prognosis. Platelet-Derived Growth Factor CC (PDGF-CC) has been implicated in the progression of various tumors, but...

    Authors: Zhenchao Luo, Fangfang Zhou, Canliang Tan, Liangchun Yin, Man Bao, Xiang He, Haohui Li and Jian Yan
    Citation: Journal of Translational Medicine 2024 22:1023
    Content type: Research Published on:

  44. CD38 is a multifunctional transmembrane glycoprotein found in multiple tissues and overexpressed in many cancer cells, notably in hematological malignancies such as leukemia and multiple myeloma (MM). Therefor...

    Authors: Valentina Bocuzzi, Jessica Bridoux, Michelle Pirotte, Nadia Withofs, Roland Hustinx, Matthias D’Huyvetter, Jo Caers and Guillaume Marcion
    Citation: Journal of Translational Medicine 2024 22:998
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Translational Medicine 2024 22:1113

  45. Gastrointestinal tumors are the main causes of death among the patients. These tumors are mainly diagnosed in the advanced stages and their response to therapy is unfavorable. In spite of the development of co...

    Authors: Min Tang, Junzhou Song, Shuyi Zhang, Xiaolei Shu, Shuang Liu, Milad Ashrafizadeh, Yavuz Nuri Ertas, Ya Zhou and Ming Lei
    Citation: Journal of Translational Medicine 2024 22:970
    Content type: Review Published on:

  46. Integrin α5β1 plays a crucial role in the invasion of nonphagocytic cells by Staphylococcus aureus (S. aureus), thereby facilitating infection development. Lipid nanoparticles (LNPs) serve as an effective vehicle...

    Authors: Meiqi Meng, Yue Li, Jiachao Wang, Xiaonan Han, Xuan Wang, Hongru Li, Bai Xiang and Cuiqing Ma
    Citation: Journal of Translational Medicine 2024 22:942
    Content type: Research Published on:

  47. Patients with glioblastoma (GBM) have a poor prognosis and limited treatment options. The mRNA decapping enzyme scavenger (DCPS) is a cap-hydrolyzing enzyme. The DCPS inhibitor RG3039 exhibited excellent centr...

    Authors: Hao Duan, Yuan Xie, Suwen Wu, Guangyin Zhao, Zhen Zeng, Hongrong Hu, Yanjiao Yu, Wanming Hu, Yuanzhong Yang, Yukun Chen, Haoqun Xie, Zexin Chen, Gao Zhang, Keith T. Flaherty, Shanshan Hu, Haineng Xu…
    Citation: Journal of Translational Medicine 2024 22:880
    Content type: Research Published on:

  48. Hydrogels are promising candidates for the delivery of therapeutics in the treatment of human cancers. Regarding to the biocomaptiiblity, high drug and encapsulation efficacy and adjustable physico-chemical fe...

    Authors: Chunbao Zang, Yu Tian, Yujing Tang, Min Tang, Dingyi Yang, Fangfang Chen, Mohammadreza Ghaffarlou, Yanyang Tu, Milad Ashrafizadeh and Yan Li
    Citation: Journal of Translational Medicine 2024 22:879
    Content type: Review Published on:

  49. Breast cancer, with its high morbidity and mortality rates, is a significant global health burden. Traditional treatments—surgery, chemotherapy, and radiotherapy—are widely used but come with drawbacks such as...

    Authors: Min Luo, Fu-kun Zhao, Yuan-min Wang and Jiang Bian
    Citation: Journal of Translational Medicine 2024 22:814
    Content type: Research Published on:

  50. Cancer is the leading cause of death worldwide, accounting for nearly 10 million deaths every year. Immune checkpoint blockade approaches have changed the therapeutic landscape for many tumor types. However, c...

    Authors: Linxue Li, Ruiwei Ye, Yingying Li, Hanyu Pan, Sheng Han and Yiming Lu
    Citation: Journal of Translational Medicine 2024 22:812
    Content type: Review Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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