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Translational Metagenomics

Section edited by Souhaila Al Khodor

© Kateryna_Kon / stock.adobe.comThe Translational Metagenomics section aims to embrace studies addressing the role of the human microbiome in health and disease. This section encompasses studies about the development and application of metagenomics, metatranscriptomics, microbial metabolomics or novel bioinformatics tools used to improve our knowledge on the microbiome. 

The Translational Metagenomics section is especially interested in studies that go beyond description of the microbial composition and include experimental models used to support the proposed role of the microbiome in human health and diseases. In addition, studies about metagenomics integration with other omics are highly recommended. Studies of pathogens interaction with the host will not be considered.

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  1. There is a dearth of population-based studies on the association between the diversity of the oral microbiome and the risk of chronic obstructive pulmonary disease (COPD). The study aims to investigate the ass...

    Authors: Xian-xin Xia, Chuan-xiang Li and Hong-rong Guo
    Citation: Journal of Translational Medicine 2025 23:557
    Content type: Research Published on:

  2. Gastrointestinal disorders (GIDs) affect nearly 40% of the global population, with gut microbiome-metabolome interactions playing a crucial role in gastric cancer (GC), colorectal cancer (CRC), and inflammator...

    Authors: Daryll Philip, Rebecca Hodgkiss, Swarnima Kollampallath Radhakrishnan, Akshat Sinha and Animesh Acharjee
    Citation: Journal of Translational Medicine 2025 23:549
    Content type: Research Published on:

  3. Failure to understand the causes of recurrent spontaneous preterm birth (sPTB) has limited effective interventions. This study aimed to examine the relationship between the vaginal microbiota and the risk of s...

    Authors: Xiang Jiang, Yirong Bao, Xiang Li, Xiaoxian Qu, Xiaoyunan Mao, Jiaqi Dong, Luyao Wang, Xiaohua Liu, Feng Zhang and Hao Ying
    Citation: Journal of Translational Medicine 2025 23:541
    Content type: Research Published on:

  4. Periodontitis is a chronic inflammatory disease that significantly impacts periodontal bone regeneration, yet the distinct biological features of osteoblasts in this condition remain poorly understood. This st...

    Authors: Rui Dong, Meihui Li, Xiu Feng Gu, Haiting Gao, Ziyi Wei, Houbao Qi, Jun Zhang and Qiang Feng
    Citation: Journal of Translational Medicine 2025 23:540
    Content type: Research Published on:

  5. Chronic atrophic gastritis (CAG) is related to the body’s microbial and metabolic systems. Combined studies of microbiome and metabolomics can clarify the mechanisms of disease occurrence and progression. We u...

    Authors: Yumei Ma, Jianming Jiang, Zhufeng Yang, Yongzhang Li, Haiyan Bai, Zongxiu Liu, Shuo Zhang, Zheng Zhi and Qian Yang
    Citation: Journal of Translational Medicine 2025 23:537
    Content type: Research Published on:

  6. Preterm birth (PTB) is a major contributor to neonatal morbidity, mortality, and long-term health complications. Despite advances in perinatal care, PTB rates remain high, and its multifactorial etiology is no...

    Authors: Azusa Uchida, Kenji Imai, Rika Miki, Tomonari Hamaguchi, Hiroshi Nishiwaki, Mikako Ito, Jun Ueyama, Satomi Hattori, Sho Tano, Kazuya Fuma, Seiko Matsuo, Takafumi Ushida, Kinji Ohno, Hiroaki Kajiyama and Tomomi Kotani
    Citation: Journal of Translational Medicine 2025 23:533
    Content type: Research Published on:

  7. Oral Lichen Planus (OLP) is a chronic inflammatory disorder that may progress to Oral Squamous Cell Carcinoma (OSCC). Lipid metabolism dysregulation has been implicated in tumor development and immune response...

    Authors: Manman Yao, Yueting Lu, Tiejun Liu, Hualin Lu, Hongyue Shang, Bo Dong and Ji-ao Zhang
    Citation: Journal of Translational Medicine 2025 23:448
    Content type: Research Published on:

  8. Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects reproductive-aged women worldwide, causing hormonal imbalances and ovarian dysfunction. PCOS affects metabolic health and increases the ri...

    Authors: Harshini Senthilkumar and Mohanapriya Arumugam
    Citation: Journal of Translational Medicine 2025 23:443
    Content type: Review Published on:

  9. The gut-lung-kidney axis is pivotal in immune-related kidney diseases, with gut dysbiosis potentially exacerbating the severity of Coronavirus disease 2019 (COVID-19) in recipients of kidney transplant. This s...

    Authors: Zijie Wang, Xiang Gao, Hongsheng Ji, Ming Shao, Bin Ni, Shuang Fei, Li Sun, Hao Chen, Ruoyun Tan, Mulong Du and Min Gu
    Citation: Journal of Translational Medicine 2025 23:420
    Content type: Research Published on:

  10. Knowledge of the urinary microbiome (urobiome) in diabetic kidney disease (DKD) remains limited. The most commonly used 16S rRNA sequencing technique can only provide bacterial identification at the genus leve...

    Authors: Nan Li, Ying Wang, Haojun Zhang, Liang Ma, Xinhui Huang, Yuhang Qiao, Han Li, Hailing Zhao and Ping Li
    Citation: Journal of Translational Medicine 2025 23:414
    Content type: Research Published on:

  11. Clinical implications of metagenomics next-generation sequencing (mNGS) in sepsis have not been fully evaluated. This study aimed to determine the diagnostic, therapeutic, and prognostic impacts of mNGS in sep...

    Authors: Feixiang Xu, Chen Chen, Su Lu, Mingming Xue, Hailin Ding, Yanli Song, Yun Zhang, Keyu Sun, Lunxian Tang, Wei Wang, Meitang Wang, Yan Tang, Dingyu Tan, Chenling Yao, Dongwei Shi, Enqiang Mao…
    Citation: Journal of Translational Medicine 2025 23:394
    Content type: Research Published on:

  12. The human gut microbiome has emerged as a potential modulator of treatment efficacy for different cancers, including non-small cell lung cancer (NSCLC) patients undergoing immune checkpoint inhibitor (ICI) the...

    Authors: Muhammad Faheem Raziq, Nadeem Khan, Haseeb Manzoor, Hafiz Muhammad Adnan Tariq, Mehak Rafiq, Shahzad Rasool, Masood Ur Rehman Kayani and Lisu Huang
    Citation: Journal of Translational Medicine 2025 23:343
    Content type: Research Published on:

  13. In order to explore the differences in gut microbiota and their metabolites between patients with H-type hypertension and non-H-type hypertension.

    Authors: Jian Wu, Jiangman Zhao, Yinhong Cheng, Haoliang Zhou, Guanqiao Shen, Hongying Ding, Jin Lv, Shiye Dong and Oushan Tang
    Citation: Journal of Translational Medicine 2025 23:329
    Content type: Review Published on:

  14. The clinical value of shotgun metagenomic next-generation sequencing (mNGS) in improving the detection rates of respiratory pathogens is well-established. However, mNGS is complex and expensive. This study des...

    Authors: Dejian Gu, Jie Liu, Jiaping Wang, Yuting Yi, Yuxing Chu, Rui Gao, Hao Liu, Jun She and Binghuai Lu
    Citation: Journal of Translational Medicine 2025 23:325
    Content type: Research Published on:

  15. Prior studies have elucidated that alterations in gut microbiota are associated with a spectrum of tumors and metabolic disorders. However, the diagnostic value of gut microbiota in epithelial ovarian cancer r...

    Authors: Cheng Chen, Chengyuan Deng, Yanwen Li, Shuguang He, Yunhong Liu, Shuwen Pan, Wenqian Xu, Lu Fang, Yixi Zhu, Yingying Wang and Xiaoxin Jiang
    Citation: Journal of Translational Medicine 2025 23:319
    Content type: Research Published on:

  16. Alzheimer’s disease (AD) is a progressive and chronic neurodegenerative disorder of the central nervous system, characterized by behavioral and dysexecutive deficits. Its pathogenesis is closely associated wit...

    Authors: Guang-sheng Liu, Yang Song, Jin-sheng Yan, Yi-jie Chai, Yun-fei Zhao and Huan Ma
    Citation: Journal of Translational Medicine 2025 23:299
    Content type: Research Published on:

  17. Clinical data on oral fecal microbiota transplantation (FMT), a promising therapy for Crohn’s disease (CD), are limited. Herein, we determined the short-term safety and feasibility of FMT for pediatric patient...

    Authors: Biao Zou, Shengxuan Liu, Chen Dong, Hexiao Shen, Yongling Lv, Jiayi He, Xuesong Li, Mengling Ruan, Zhihua Huang and Sainan Shu
    Citation: Journal of Translational Medicine 2025 23:288
    Content type: Research Published on:

  18. Rheumatoid arthritis (RA) is a complex autoimmune and inflammatory disease that significantly impacts the quality of life for millions worldwide. In recent years, gut microbiota has garnered extensive attentio...

    Authors: Weiya Lan, Qianwei Lu, Wukai Ma, Zong Jiang, Yu Chen, Zhengzhen Wang, Xueming Yao and Fang Tang
    Citation: Journal of Translational Medicine 2025 23:187
    Content type: Research Published on:

  19. Lung cancer (LC) remains the leading cause of cancer death globally. Recent reports have suggested that circulating microbial nucleic acids have potential as promising biomarkers for cancer liquid biopsies. Ho...

    Authors: Huijuan Chen, XueNa Yao, Chunyan Yang, Yiran Zhang, Henan Dong, Jincheng Zhai, Dongjie Fan and Qiming Zhou
    Citation: Journal of Translational Medicine 2025 23:186
    Content type: Research Published on:

  20. Colorectal cancer (CRC) presents a complex tumor microenvironment influenced by genetic and microbial factors. Microbial DNA from the gut and tumor microenvironment can translocate into the bloodstream, formin...

    Authors: Liang Ma, Mingliang Shi, Xue Zhang, Yan Liu, Hui Jin, Dan Li, Hui Zhang, Li Feng, Jing Zuo, Yudong Wang, Jiayin Liu and Jing Han
    Citation: Journal of Translational Medicine 2025 23:178
    Content type: Research Published on:

  21. Prostate cancer is one of the most common cancers in the United States with a high mortality rate. In recent years, the traditional opinion about prostate microbiome was challenged. Although there still are so...

    Authors: Gui-Chen Ye, Hao Peng, Jia-Cheng Xiang, Ling-Tao Miao, Cheng-Zhi Liu, Shao-Gang Wang and Qi-Dong Xia
    Citation: Journal of Translational Medicine 2025 23:130
    Content type: Research Published on:

  22. Inflammatory bowel disease (IBD) is a chronic condition influenced by diet, which affects gut microbiota and immune functions. The rising prevalence of IBD, linked to Western diets in developing countries, hig...

    Authors: Qi Sun, Bai-Rong Li, Dong-Hao Li, Xiao-Ying Wang, Qian-Yi Wang, Zhi-Meng Jiang, Shou-Bin Ning and Tao Sun
    Citation: Journal of Translational Medicine 2025 23:93
    Content type: Research Published on:

  23. Preeclampsia (PE) is a pregnancy complication characterized by high blood pressure and organ damage. This study investigates the differences in the gut microbiota between preterm neonates born to mothers with ...

    Authors: Yang Chen, Zhou-Ting Yi, Hai-Long Yu, Xiao-Yan Wu, Jun-Ping Wang, Chuan Nie, Hui Li, Sheng-Hui Li, Qiu-Long Yan, Tian-Wen He, Min-Chai Chen, Xin-Yue Yang, Ji-Ying Wen and Li-Juan Lv
    Citation: Journal of Translational Medicine 2025 23:84
    Content type: Research Published on:

  24. The conversion of primary bile acids to secondary bile acids by the gut microbiota has been implicated in colonic inflammation. This study investigated the role of gut microbiota related bile acid metabolism i...

    Authors: Liping Chen, Zhenghao Ye, Junhua Li, Lijia Wang, Yu Chen, Meiping Yu, Jian Han, Jiangeng Huang, Dongyan Li, Yongling Lv, Kai Xiong, De’an Tian, Jiazhi Liao, Ursula Seidler and Fang Xiao
    Citation: Journal of Translational Medicine 2025 23:55
    Content type: Research Published on:

  25. This study investigated the oral microbiome signatures associated with upper gastrointestinal (GI) and pancreaticobiliary cancers.

    Authors: Sujin Oh, Jaihwan Kim, Cheol Min Shin, Hyo-Jung Lee, Hye Seung Lee and Kyoung Un Park
    Citation: Journal of Translational Medicine 2025 23:20
    Content type: Research Published on:

  26. Autism spectrum disorder (ASD) is a persistent neurodevelopmental disorder affecting brains of children. Mounting evidences support the associations between gut microbial dysbiosis and ASD, whereas detailed me...

    Authors: Li Shao, Guangyong Cai, Jinlong Fu, Weishi Zhang, Yuefang Ye, Zongxin Ling and Shiwei Ye
    Citation: Journal of Translational Medicine 2024 22:1165
    Content type: Research Published on:

  27. Ureaplasma urealyticum, Ureaplasma parvum, and Mycoplasma hominis were widely known as ammonia-producing microorganisms and can cause hyperammonemia, leading to cerebral edema and altered consciousness, which rep...

    Authors: Jun Xu, Xindie Ren, Xiaohan Huang, Yue Jin, Mingqiang Wang, Lin Zhong, Guojun He, Shengfeng Wang, Qianqian Wang, Muhua Dai, Yonghui Xiong, Yinghe Xu, Xuwei He, Yujie Pan, Hongyu Wang, Qi Xia…
    Citation: Journal of Translational Medicine 2024 22:1148
    Content type: Research Published on:

  28. Previous research on the lower gastrointestinal tract has proved that microbial dysbiosis can lead to intestinal barrier dysfunction and enhanced visceral sensitivity, thus triggering bowel symptoms. Whether e...

    Authors: Songfeng Chen, Dianxuan Jiang, Qianjun Zhuang, Xun Hou, Xingyu Jia, Jing Chen, Huiting Lin, Mengyu Zhang, Niandi Tan and Yinglian Xiao
    Citation: Journal of Translational Medicine 2024 22:1145
    Content type: Research Published on:

  29. The rising prevalence of Type 2 diabetes mellitus (T2D) in the Qatari population presents a significant public health challenge, highlighting the need for innovative approaches to early detection and managemen...

    Authors: Selvasankar Murugesan, Ghada Yousif, Mohamed Nadhir Djekidel, Giusy Gentilcore, Jean Charles Grivel and Souhaila Al Khodor
    Citation: Journal of Translational Medicine 2024 22:1132
    Content type: Research Published on:

  30. The aim of this study was to explore the microbial variations and biomarkers in the oral environment of patients with persistent pulmonary nodules (pPNs) and to reveal the potential biological functions of the...

    Authors: Xiao Zeng, Qiong Ma, Chun-Xia Huang, Jun-Jie Xiao, Xi Fu, Yi-Feng Ren, Yu-Li Qu, Hong-Xia Xiang, Mao Lei, Ru-Yi Zheng, Yang Zhong, Ping Xiao, Xiang Zhuang, Feng-Ming You and Jia-Wei He
    Citation: Journal of Translational Medicine 2024 22:1079
    Content type: Research Published on:

  31. Acute pancreatitis (AP) is an inflammatory condition with potentially life-threatening complications. This study investigates the therapeutic potential of Clostridium butyricum for modulating the inflammatory cas...

    Authors: Biyan Wen, Yaoxing Huang, Guiqing Deng, Qingqing Yan and Lin Jia
    Citation: Journal of Translational Medicine 2024 22:1072
    Content type: Research Published on:

  32. Hashimoto's thyroiditis (HT) is an autoimmune disorder with unclear molecular mechanisms. While current diagnosis is well-established, understanding of the gut-thyroid axis in HT remains limited. This study ai...

    Authors: Miao Li, Ke Chen, Yuqi Chen, Lei Zhang, Yipeng Cui, Fengxu Xiao, Zhenting Liu, Wen Zhang, Jue jiang, Qi Zhou, Jiangwei Yan, Yu Sun and Fanglin Guan
    Citation: Journal of Translational Medicine 2024 22:1045
    Content type: Research Published on:

  33. Advanced-stage non-small cell lung cancer (NSCLC) poses treatment challenges, with immune checkpoint inhibitors (ICIs) as the main therapy. Emerging evidence suggests the gut microbiome significantly influence...

    Authors: David Dora, Peter Kiraly, Csenge Somodi, Balazs Ligeti, Edit Dulka, Gabriella Galffy and Zoltan Lohinai
    Citation: Journal of Translational Medicine 2024 22:1044
    Content type: Research Published on:

  34. Intestinal flora promotes the pathogenesis of colorectal cancer (CRC) through microorganisms and their metabolites. This study aimed to investigate the composition of intestinal flora in different stages of CR...

    Authors: Qishi Song, Yongchao Gao, Kun Liu, Yukai Tang, Yichun Man and Haijun Wu
    Citation: Journal of Translational Medicine 2024 22:1028
    Content type: Research Published on:

  35. Hyperuricemia is considered as an independent risk factor for acute ischemic stroke (AIS), and some AIS patients are accompanied by an increase in serum uric acid. Recent studies have highlighted the important...

    Authors: Hongming Wei, Lu Zhan, Xinhuang Lv, Yan Lin, Jie Zheng, Wenwen Yang, Jiaming Liu, Jing Sun and Songfang Chen
    Citation: Journal of Translational Medicine 2024 22:999
    Content type: Research Published on:

  36. Mounting evidence suggests a significant role of the gut microbiota in the development and progression of colorectal cancer (CRC). In particular, an over-representation of oral pathogens has been linked to CRC...

    Authors: Thyra Löwenmark, Linda Köhn, Therese Kellgren, William Rosenbaum, Vicky Bronnec, Anna Löfgren-Burström, Carl Zingmark, Pär Larsson, Michael Dahlberg, Bjoern O. Schroeder, Sun Nyunt Wai, Ingrid Ljuslinder, Sofia Edin and Richard Palmqvist
    Citation: Journal of Translational Medicine 2024 22:947
    Content type: Research Published on:

  39. Periodontitis results from host-microbe dysbiosis and the resultant dysregulated immunoinflammatory response. Importantly, it closely links to numerous systemic comorbidities, and perplexingly contributes to a...

    Authors: Tianfan Cheng, Ping Wen, Rong Yu, Feng Zhang, Huijun Li, Xiaoyi Xu, Dan Zhao, Fang Liu, Weilan Su, Zheng Zheng, Hong Yang, Jilong Yao and Lijian Jin
    Citation: Journal of Translational Medicine 2024 22:819
    Content type: Research Published on:

  40. The prevalence of chronic kidney disease (CKD) is on the rise, posing a significant public health challenge. Although gut microbiome dysbiosis has been implicated in the impairment of kidney functions, the exi...

    Authors: Jing Li, Yang Shen, Kaixin Yan, Siyuan Wang, Jie Jiao, Hongjie Chi, Jiu-chang Zhong, Ying Dong and Pan Wang
    Citation: Journal of Translational Medicine 2024 22:773
    Content type: Research Published on:

  41. Acute graft-versus-host disease (aGVHD) is primarily driven by allogeneic donor T cells associated with an altered composition of the host gut microbiome and its metabolites. The severity of aGVHD after alloge...

    Authors: Lijie Han, Xianlei Sun, Jingjing Kong, Jin Li, Kai Feng, Yanliang Bai, Xianjing Wang, Zhenhua Zhu, Fengyuan Yang, Qingzhou Chen, Mengmeng Zhang, Baohong Yue, Xiaoqian Wang, Liyan Fu, Yaoyao Chen, Qiankun Yang…
    Citation: Journal of Translational Medicine 2024 22:746
    Content type: Research Published on:

  42. Metabolic syndrome (MetS) is highly prevalent in individuals with schizophrenia (SZ), leading to negative consequences like premature mortality. Gut dysbiosis, which refers to an imbalance of the microbiota, a...

    Authors: Zongxin Ling, Zhiyong Lan, Yiwen Cheng, Xia Liu, Zhimeng Li, Ying Yu, Yuwei Wang, Li Shao, Zhangcheng Zhu, Jie Gao, Wenhui Lei, Wenwen Ding and Rongxian Liao
    Citation: Journal of Translational Medicine 2024 22:729
    Content type: Research Published on:

  43. Cancer remains a leading cause of global mortality. The tumor microbiota has increasingly been recognized as a key regulator of cancer onset and progression, in addition to shaping tumor responses to immunothe...

    Authors: Jie Qiu, Yuancong Jiang, Nanwei Ye, Gan Jin, Hao Shi and Da Qian
    Citation: Journal of Translational Medicine 2024 22:728
    Content type: Review Published on:

  44. Specific alterations in gut microbiota and metabolites have been linked to AMI, with CBLB potentially playing an essential role. However, the precise interactions remain understudied, creating a significant ga...

    Authors: Hongjun You, Fengjun Chang, Haichao Chen, Yi Wang and Wenqi Han
    Citation: Journal of Translational Medicine 2024 22:654
    Content type: Research Published on:

  45. The incidence of early-stage lung adenocarcinoma (ES-LUAD) is steadily increasing among non-smokers. Previous research has identified dysbiosis in the gut microbiota of patients with lung cancer. However, the ...

    Authors: Yaohui Sun, Zhiming Gan, Xiaojin Wang, Jian Liu, Wei Zhong, Zhiyan Zhang, Jiebin Zuo, Hang Zhong, Xiuting Huang, Zhixiang Yan and Qingdong Cao
    Citation: Journal of Translational Medicine 2024 22:652
    Content type: Research Published on:

  46. Bladder cancer is a common malignancy with high recurrence rate. Early diagnosis and recurrence surveillance are pivotal to patients’ outcomes, which require novel minimal-invasive diagnostic tools. The urinar...

    Authors: Cen Wu, Xiaoyu Wei, Zhiyang Huang, Zhixiong Zheng, Wei Zhang, Jiajun Chen, Hongchang Hong and Weili Li
    Citation: Journal of Translational Medicine 2024 22:628
    Content type: Research Published on:

  47. Variations exist in the response of patients with Crohn’s disease (CD) to ustekinumab (UST) treatment, but the underlying cause remains unknown. Our objective was to investigate the involvement of immune cells...

    Authors: Qing Li, Zicheng Huang, Hongsheng Yang, Jian Tang, Tao Zuo, Qingfan Yang, Zhaopeng Huang, Qin Guo, Miao Li, Xiang Gao and Kang Chao
    Citation: Journal of Translational Medicine 2024 22:595
    Content type: Research Published on:

  48. Predictive markers for fecal microbiota transplantation (FMT) outcomes in patients with active ulcerative colitis (UC) are poorly defined. We aimed to investigate changes in gut microbiota pre- and post-FMT an...

    Authors: Jingshuang Yan, Guanzhou Zhou, Rongrong Ren, Xiaohan Zhang, Nana Zhang, Zikai Wang, Lihua Peng and Yunsheng Yang
    Citation: Journal of Translational Medicine 2024 22:589
    Content type: Research Published on:

  49. Exploration of adaptive evolutionary changes at the genetic level in vaginal microbial communities during different stages of cervical cancer remains limited. This study aimed to elucidate the mutational profi...

    Authors: Menglu Hu, Wentao Yang, Ruiyi Yan, Jiayu Chi, Qi Xia, Yilin Yang, Yinhan Wang, Lejia Sun and Ping Li
    Citation: Journal of Translational Medicine 2024 22:559
    Content type: Research Published on:

  50. Dysbiosis of the gut microbiota is pivotal in Crohn’s disease (CD) and modulated by host physiological conditions. Hyperbaric oxygen therapy (HBOT) is a promising treatment for CD that can regulate gut microbi...

    Authors: Yong Li, Ruizheng Sun, Chen Lai, Kezhen Liu, Huixiang Yang, Ziheng Peng, Duo Xu, Fangling Huang, Keke Tang, Yu Peng and Xiaowei Liu
    Citation: Journal of Translational Medicine 2024 22:518
    Content type: Research Published on:

Journal of Translational Medicine

ISSN: 1479-5876

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