Fig. 7

The interaction between stromal cells and immune cells contributed to inflammation in immune-related myocarditis. (A) Heatmaps showing the signaling roles and contributions of cell subpopulations in the CXCL signaling pathway network. (B) Heatmaps showing the signaling roles and contributions of cell subpopulations in the CCL signaling pathway network. (C) Interaction strengths of CXCL signaling pathways between myeloid cell subpopulations (senders) and venous ECs (receivers) in the irAE and normal groups. (D) Bubble plot showing the enriched ligand-receptor pairs of CXCL signaling pathways between myeloid cell subpopulations and venous ECs in the irAE and normal groups. (E) Chord diagrams of CCL and CXCL signaling pathways between fibroblast subpopulations (senders) and endothelial cell subpopulations (receivers). (F) Bubble plot showing the enriched ligand-receptor pairs of CCL and CXCL signaling pathways between CXCL9 + fibroblasts and other cells. CCL, C-C motif chemokine ligand; CXCL, C-X-C motif chemokine ligand; irAE, immune-related adverse event