Fig. 6
CXCL9 + fibroblasts played an important role in inflammation. (A) UMAP projection of all fibroblasts across all samples as well as the irAE and normal groups, respectively. (B) Heatmap showing marker gene expression of fibroblast subpopulations. (C) Enriched GO pathway terms of marker genes of each fibroblast subpopulation. (D) Heatmap of normalized PROGENy pathway activity scores of fibroblast subpopulations. (E) Bar plot showing the enrichment scores of top transcription factors upregulated (red) and downregulated (blue) in CXCL9 + fibroblasts. (F) Heatmap showing the cytokine signaling scores of four fibroblast subsets. (G) Incoming and outgoing interaction strengths of all cell clusters in human heart tissues. GPX3 + Fibro, GPX3 + fibroblast; BTG2 + Fibro, BTG2 + fibroblast; CXCL9 + Fibro, CXCL9 + fibroblast; POSTN + Fibro, POSTN + fibroblast; TFs, transcription factors; UMAP, Uniform Manifold Approximation and Projection; irAE, immune-related adverse event