Fig. 5

Endothelial cells were closely associated with immune-related myocarditis. (A) UMAP projection of all vascular cells across all samples as well as the irAE and normal groups, respectively. (B) Dot plot showing the expression levels of marker genes of each subpopulation. (C) GO analysis of specific marker genes of venous ECs. (D) Volcano plot showing DEGs of endothelial cells between the irAE group and the normal group. (E) Top enriched KEGG pathways of upregulated genes of endothelial cells in the irAE group. arterial EC, arterial endothelial cell; capillary EC, capillary endothelial cell; immune capillary EC, immune capillary endothelial cell; venous EC, venous endothelial cell; lymphatic EC, lymphatic endothelial cell; UMAP, Uniform Manifold Approximation and Projection; irAE, immune-related adverse event