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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Potential of CLSPN as a therapeutic target in melanoma: a key player in melanoma progression and tumor microenvironment

Fig. 6

The role of compounds in melanoma based on cMAP prediction. (A) Chemical formula structure diagrams of the 3 top compounds with the highest scores in the cMAP analysis. The inhibitory effects of different CGP-52,411 and TAK-715 concentrations on A375 (B) and A2058 (C) after incubation for 24 h. The effects of CGP-52,411 and TAK-715 on A375 (D) and A2058 (E) colony formation. (F) Representative images of migration in A375 and A2058 after CGP-52,411 and TAK-715 treated. (G) Cell apoptosis in A375 after CGP-52,411 and TAK-715 treated. cMAP, connectivity map. Data were expressed as mean ± SD. *** p < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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