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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Potential of CLSPN as a therapeutic target in melanoma: a key player in melanoma progression and tumor microenvironment

Fig. 3

CLSPN knockdown promotes the apoptosis abilities of melanoma cells. (A-B) Cell apoptosis in A375 and A2058 after CLSPN knockdown by the flow cytometry with quantitative assessment. (C) The protein levels of Bcl-2, Bax of A375 and A2058 cells after si-CLSPN transfection measured by western blot. (D) The Bax/Bcl-2 ratio of A375 and A2058. (E) The protein expressions of cleaved-caspase-9 and cleaved-PARP, and the quantitative analysis of their expressions in A375 and A2058 cells after si-CLSPN. Data were expressed as mean ± SD. * p < 0.05, ** p < 0.01 and *** p < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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