Fig. 11

Inhibition of OC-STAMP in mouse lung tissue inhibits M1-type giant filament cell polarisation and enhances M2 polarisation. A–D Flow cytometry detection of alveolar macrophages, interstitial macrophages in rat lung tissues from silica modelling group, OC-STAMP siRNA intervention group and control group (n = 3). E, F Proportion of CD86+ positive cells in alveolar macrophages (n = 3). G, H Proportion of MHC-II+ positive cells in alveolar macrophages (n = 3). I, J Proportion of CD206+ positive cells in alveolar macrophages (n = 3). K, L Proportion of CD86+ positive cells in interstitial lung macrophages (n = 3). M, N Proportion of MHC-II+ positive cells in interstitial lung macrophages (n = 3). O, P Proportion of CD206+ positive cells in interstitial lung macrophages (n = 3). All data are expressed as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001