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Table 1 Characteristics of heart failure (HF)-progressors from STOP-HF cohort

From: Proteomic-based biomarker discovery reveals panels of diagnostic biomarkers for early identification of heart failure subtypes

 

No-HF

P-value (no-HF) (baseline vs Dx)

HFpEF

P-value (HFpEF) (baseline vs Dx)

HFrEF

P-value (HFrEF) (baseline vs Dx)

Overall

 

Baseline

Dx

Baseline

Dx

Baseline

Dx

Baseline

Dx

 

(n=12)

(n=12)

(n=14)

(n=14)

(n=14)

(n=14)

(n=40)

(n=40)

Gender

           

 Female

6

6

 

7

7

 

7

7

 

20

20

 (%)

(50.0%)

(50.0%)

>0.9999

(50.0%)

(50.0%)

>0.9999

(50.0%)

(50.0%)

>0.9999

(50.0%)

(50.0%)

 Male

6

6

7

7

7

7

20

20

 (%)

(50.0%)

(50.0%)

 

(50.0%)

(50.0%)

 

(50.0%)

(50.0%)

 

(50.0%)

(50.0%)

Age (years)

           

 Mean

74.4

76.1

 

75.0

76.9

 

72.7

74.5

 

74.0

75.8

 (SD)

(4.61)

(4.31)

0.0005

(6.46)

(6.44)

0.0001

(7.35)

(7.36)

<0.0001

(6.24)

(6.18)

 Median

72.8

74.4

76.1

78.1

72.7

74.3

74.2

75.8

 [IQR]

[4.52]

[3.20]

 

[3.30]

[3.40]

 

[8.16]

[8.47]

 

[6.06]

[5.87]

EF (%)

           

 Mean

68.3

68.9

 

69.1

66.6

 

47.1

38.1

 

61.2

57.3

 (SD)

(6.61)

(5.33)

0.7251

(7.39)

(6.01)

0.2129

(9.88)

(6.98)

0.0007

(13.1)

(15.5)

 Median

68.0

70.0

69.5

67.0

50.0

39.0

62.5

62.0

 [IQR]

[6.25]

[5.50]

 

[14.3]

[9.25]

 

[11.9]

[9.25]

 

[20.3]

[25.8]

BNP (pg/ml)

           

 Mean

37.6

40.6

 

111

210

 

130

382

 

95.4

220

 (SD)

(24.2)

(14.7)

0.712

(75.2)

(175)

0.0107

(83.8)

(379)

0.0006

(76.9)

(278)

 Median

29.1

42.5

84.4

154

136

240

70.7

128

 [IQR]

[27.6]

[18.6]

 

[88.4]

[107]

 

[104]

[285]

 

[105]

[188]

  1. Chi-squared test is used for categorical variables, and paired t test or Wilcoxon matched-pairs signed rank test is used for numerical variables
  2. Dx diagnosis, EF ejection fraction, BNP b-type natriuretic peptide, No-HF no heart failure, HFpEF heart failure with preserved ejection fraction, HFrEF heart failure with reduced ejection fraction, SD standard deviation, IQR interquartile range