Association between oral microbiome diversity and chronic obstructive pulmonary disease in the US population

Table 2 Association between alpha diversity and risk of COPD in logistic regression models, weighted

	OR (95%CI) P-value
	unadjusted	Model 1	Model 2	Model 3
Observed ASVs	0.938 (0.912–0.964) < 0.001	0.976 (0.948–1.004) 0.087	0.974 (0.947–1.001) 0.063	0.964 (0.936–0.993) 0.016
Faith’s phylogenetic Diversity	0.929 (0.896–0.962) < 0.001	0.974 (0.939–1.011) 0.164	0.967 (0.932–1.003) 0.069	0.955 (0.919–0.993) 0.020
Shannon-Weiner index	0.775 (0.672–0.894) < 0.001	0.851 (0.728–0.994) 0.042	0.857 (0.729–1.007) 0.061	0.829 (0.702–0.981) 0.029
Simpson Index	1.006 (0.872–1.161) 0.932	0.983 (0.848–1.141) 0.825	0.968 (0.824–1.138) 0.694	0.955 (0.810–1.126) 0.586

Bold represents P-value < 0.05
ASVs, Amplicon sequence variants; PIR, family poverty income ratio; BMI, body mass index; OR, odds ratio; 95% CI, 95% confidence intervals
Model 1: Adjusted for age, gender, race, education level, marital status, and PIR
Model 2: Adjusted for Model 1 plus BMI, drinking status, and smoking status
Model 3: Adjusted for Model 2 plus hypertension, diabetes, and periodontitis
Note: α diversity changes corresponding to the effect values in the regression models are as follows: for observed ASVs, a 10-unit increase; for Faith’s phylogenetic Diversity, a 1-unit increase; for the Shannon-Weiner index, a 1-unit increase; and for the Simpson Index, a 0.1-unit increase

ISSN: 1479-5876