Fig. 5

Dotplot representation of the top 20 most significantly enriched Gene Ontology Biological Pathways terms (both activated and suppressed) in comparison TRI-001 Hypoxia vs. TRI-001 Normoxia. X-axis shows the gene ratios of the enriched terms (i.e., the fraction of core enrichment genes vs. all genes associated with the pathway). Y-axis displays the enriched terms ordered by the gene ratio. Dot sizes depict the number of genes associated with the respective term. Dot color scale depicts the statistical significance of the enrichment, with dark blue and light blue indicating the lowest and highest adjusted p-values, respectively