Fig. 4

Comparison of TRI-001 gene expression under inflammatory and hypoxic conditions. Principal component analysis of the top 500 genes by sample variance of VST-transformed expression values. PC1 and PC2 are shown on the x- and y-axis, respectively. Groups are indicated with colors (A). Pairwise Pearson’s correlations of the top 500 most variable genes. Samples are clustered using hierarchical clustering based on Pearson’s correlation coefficients. Groups are annotated with symbols on the top. Pearson’s correlations are visualized as a color scale from blue (low) to yellow (mid) to red (high) (B). Hierarchically clustered heatmap showing normalized expression of 25 pre-selected marker genes. Samples are clustered using hierarchical clustering based on VST-transformed expression values. Rows show genes and columns show samples. Normalized expression values are visualized as a color scale from yellow (low) to brown (high) (C)