Fig. 1

Schematic representation of the TRI-001 production process and outline of the cell culture experiments. CD14 + monocytes are isolated from leukopaks using magnetic bead sorting followed by differentiation into TRI-001 over a period of 7 days (A). Induction of hypoxia/reperfusion using an enzyme-based hypoxia model in vitro (B). Induction of inflammation using LPS stimulation in vitro (C)