Fig. 7
From: Innovative evaluation of selinexor and JQ1 synergy in leukemia therapy via C-MYC inhibition
The efficacy of Selinexor and JQ1 in a PDX mouse model. (A) Diagram of the PDX mouse model. the P1 NOG mice were randomly divided into four groups: vehicle, Selinexor (10 mg/kg), JQ1 (40 mg/kg) or Selinexor with JQ1. (B-E) The proportion of GFP-positive cells in different tissues after treatment with Selinexor and JQ1, respectively in PB (B), BM (C), SP (D) and Liver (E). (F-G) Spleen weight (F) and morphological size (G) after treatment with Selinexor and JQ1. (H) Survival curves of mice after treatment with Selinexor and JQ1. *, p < 0.05; **, p < 0.01; ***, p < 0.001