Fig. 4
From: Innovative evaluation of selinexor and JQ1 synergy in leukemia therapy via C-MYC inhibition
The efficacy of Selinexor and JQ1 in a mouse model of bone marrow transplantation. (A) Diagram of the MLL-AF9 mouse model. (B-E) The proportion of GFP-positive cells in different tissues after treatment with Selinexor (10 mg/kg) and JQ1 (40 mg/kg), respectively in PB (B), BM (C), SP (D) and Liver (E). (F) Pathological morphological pictures of the spleen and liver treatment with Selinexor and JQ1. (G-H) Spleen weight (G) and morphological size (H) after treatment with Selinexor and JQ1. (I) Survival curves of mice after treatment with Selinexor and JQ1. *, p < 0.05; **, p < 0.01; ***, p < 0.001