Table 2 Endothelial-derived EVs main cargo and roles

miR-10a, 19a, 23b, 101, 143, and 145

Suppress NF-kB, limit atherosclerotic plaque

miR-126 and miR-181b

Reduce monocyte activation

miR-146a

Reduces cardiac contractile function

A_{2 A}R

Hyperhomocysteinemia in CAD

miR-126-5p

Reduces endothelial dysfunction, improves cardiac function in HF

miR-1, miR-30, miR-133a, miR-208, miR-499

More sensible than hs-TnI in AMI

miR-499-5p

Superior to hs-cTnT in NSTEMI vs acute HF

miR-208a

Correlates with severity and mortality in AMI

miR-192, miR-194 and miR-34a

Correlate with LVEDD in AMI

miR-423-3p

Reduces cell apoptosis in IRI

miR-214

Prevents calcium overload

miR- 155

Inflammatory macrophage polarization

miR-29b and miR-455

Antifibrotic

miR-712 and miR-205

Enhance endothelial inflammation

HSP70, Arginase-1

Endothelial dysfunction

miR-122 and miR-192

Obesity and insulin resistance

miR-29a

Obesity, correlates with NT-proBNP

miR-410-5p

Cardiac fibrosis

miR-132 and miR-17-5p

Inverse correlation with BMI

miR-423-5p, miR-520c-3p and miR-15a

Morbid obesity and metabolic syndrome

miR-483

Insulin resistance, dyslipidemia, obesity, risk of developing T2DM

miR-21

Reduced in T2DM and metabolic syndrome

IgG

Retinal damage in T2DM

TGF-β1

Apoptosis in renal glomerular cells