Fig. 1

Extracellular vesicles (EVs) biogenesis. Mechanisms of extracellular vesicle release and EV markers. ALIX ALG-2-interacting protein X, CD cluster of differentiation, ESCRT endosomal sorting complex required for transport, HRS hepatocyte growth factor-regulated tyrosine kinase substrate, HSP heat shock protein, ILVs intraluminal vesicles, MHC major histocompatibility complex, MVB multivesicular bodies, sEVs soluble extracellular vesicles, TSG101 tumor susceptibility gene 101 protein