Fig. 6

The spatial patterns of cellular states in OV. (A) Overview of delineation of tumor boundary. (B) Tissue slide of OV are annotated by malignant spots (Mal, red), boundary spots (Bdy, blue) and non-malignant spots (nMal, orange). (C) Heatmap showing the scores of marker genes for cellular states in Mal, Bdy and nMal regions. * indicates p-value < 0.05. (D-F) Violin plots showing the scores of marker genes for cellular states in Mal, Bdy and nMal regions. P-values are calculated using Kruskal-Wallis tests followed by Wilcoxon’s rank sum tests for pairwise comparisons. (D) for fibroblasts S01. (E) for NK cells S01. (F) for NK cells S03. ** indicates p-value < 0.01 and **** indicates p-value < 0.0001 (G) Spatial feature plots of marker genes scores of NK cells S01 in OV