Fig. 2
From: Role of tumor microenvironment in ovarian cancer metastasis and clinical advancements
Schematic representation of the TIME. Multiple immune cell subpopulations are present in the TIME, which play an important role in OC development, progression and metastasis. Red arrows represent the functions of pro- tumoral cells, including Treg cells, MDSCs, TAMs and immature DC cells, which promote tumor escape. Blue arrows represent the functions of anti-tumoral cells, such as CD8 T cells, mature DC cells, NK cells and TAN cells, which contribute to tumor killing. OC, ovarian cancer; TIME, tumor immune microenvironment; MDSCs, Myeloid-derived suppressor cells; TAMs, Tumor-associated macrophages; DC cells, Dendritic cells; NK cells, Natural killer cells; TAN, Tumor-associated neutrophil