Fig. 1
Differential expressed genes analysis. A Statistical histograms of the DEGs, blue bar represent the number of upregulated genes and red bar represent the number of downregulated genes. B Volcano plot of DEGs, set |log2(fold-change)|> 1 and P < 0.05 as significance criteria. Red dots are upregulated genes, and green dots are downregulated genes. C Heatmap of DEGs, the vertical axis represents DEGs, the horizontal axis represents sample. Red represents upregulated genes and green represents downregulated genes. D Clustering dendrogram of the genes involved. E Heatmap of the correlations between MEs and clinical traits. Correlation coefficients and corresponding P-values are shown in the rectangles and the brackets, respectively. F Dot plot of GO analysis for blue module DEGs. G Dot plot of GO analysis for green module DEGs. H Dot plot of KEGG pathway enrichment analysis for blue and green module DEGs