Table 1 The detailed information of driver modules identified in BLCA cohort

M1

APC, SEC31A, LAMA3, NOSTRIN, FHOD1, NUP98, RANBP9, EPAS1, KRT15, NUPL2, GIGYF2, AXIN1, DLG3, CYTH2

24%

1.00E-16

6.00E-16

M2

AXIN1, APC, LRP5, CTNNB1

9%

1.00E-16

6.00E-16

M3

BIRC3, CASP3, UBC, UBE2D2, UBE2N, CASP7

3%

1.00E-16

6.00E-16

M4

CTNNB1, APC, AXIN1, PSEN1, BTRC, FBXW11, PTPRJ, CDH3, HNF1A, TRRAP, CDH1, JUP

21%

1.00E-16

6.00E-16

M5

EGFR, ERBB2, PIK3C2B, HSP90AA1, CTNND1, PLSCR1, LRIG1, GRB10, NCK1, EPN1, RGS16, STAT5B, SHC1, PTK2B, GAB1, SOS1

25%

1.00E-16

6.00E-16

M6

EP300, CREBBP, PPARG, KLF5, MYB, PPARA, HDAC1, BRCA1, STAT2, NCOA3, NAP1L1, GRIP1

35%

1.00E-16

6.00E-16

M7

ERBB2, HSP90AA1, ERBB2IP, UBC, STUB1, EGFR, SHC1

17%

1.00E-16

6.00E-16

M8

MAP3K1, MAP2K4, UBC, MAP2K1, MAP2K7, YWHAE, UBE2D4, UBE2D2, UBE2D3, MAP4K2

6%

1.00E-16

6.00E-16

M9

PDGFRB, PIK3R1, KRTAP4-12, NCK1, SHC1, UBC

5%

1.00E-16

6.00E-16

M10

PIK3R1, GAB1, PDGFRB, VAV1, IRS1, KIT, SYNJ2, UBC, ABL1, FYN, LCP2, PLCG2, LCK, PIK3CD

14%

1.00E-16

6.00E-16

M11

PLCG1, ERBB2, PDGFRB, GAB1, KDR, UBC, SHC1, LCP2, KIT, FGFR1, FLT1

20%

1.00E-16

6.00E-16

M12

RANBP2, AKAP13, TAF1, UBC, SUMO1

10%

1.00E-16

6.00E-16

M13

SMAD2, SMARCC2, EP300, SMAD3, CREBBP, HDAC1, ERBB2IP, NCOA3, SMARCC1, PIAS4, SMURF1

31%

1.00E-16

6.00E-16

M14

SMAD3, CREBBP, EP300, ERBB2IP, MECO, HOXC11, HDAC1, UBC, PIAS4, SMURF1

28%

1.00E-16

6.00E-16

M15

SMAD4, TFE3, EWSR1, SKIL, BTRC, TGFBR1, SMAD9, PIAS1, JUNB, UBE2I

9%

1.00E-16

6.00E-16

M16

SRC, RASA1, ASAP2, RXRA, BCAR1, ESRRA, STAT3, STAT1, MET, ADRB2, KHDRBS1

16%

1.00E-16

6.00E-16

M17

TNFAIP3, TBK1, TAX1BP1, UBC, RNF11, YWHAH

5%

1.00E-16

6.00E-16

M18

USP8, UBC, STAM2, CHMP1B, RNF41

5%

1.00E-16

6.00E-16

M19

ZBTB16, NCOR1, SIN3A, NCOR2, RUNX1T1, PGAM5, HDAC1, LMTK3, FCHO1, KRTAP4-12, GCSH, LDOC1, COQ6

17%

1.00E-16

6.00E-16