Journal of Translational Medicine

Table 4 Targeting of MKLN1 and MMP14 and drug-repositioning candidates for colorectal cancer

From: Identification of MMP14 and MKLN1 as colorectal cancer susceptibility genes and drug-repositioning candidates from a genome-wide association study

MKLN1		MMP14 (ref^a)		MMP14 (alt^b)
Drug	Binding score	Drug	Binding score	Drug	Binding score
GW0742	3.79	GW0742	12.06	Meropenem	14.72
Fulvestrant	10.18	Meropenem	13.78	Fulvestrant	15.91
Clobetasone butyrate	11.46	Fulvestrant	13.81	Halobetasol propionate	17.56
Meropenem	12.11	Halobetasol propionate	15.92	Clobetasone butyrate	19.02
Halobetasol propionate	12.27	Norethindrone	18.09	Norethindrone	21.13
Butofilolol	12.38	Clobetasone butyrate	18.69	GW0742	21.15

^aMMP14 with the reference allele (G) for rs3751489
^bMMP14 with the alternate allele (A) for rs3751489

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ISSN: 1479-5876

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