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Table 1 Characteristics of participants included in the discovery genome-wide association study (GWAS) on colorectal cancer risk

From: Identification of MMP14 and MKLN1 as colorectal cancer susceptibility genes and drug-repositioning candidates from a genome-wide association study

Characteristics

Case (N = 500)

Control (N = 1,500)

P-valuea

N (%)

N (%)

Age (year)

  

0.954

 Mean (SD)

63.0 (7.15)

62.9 (7.07)

 

Sex

  

 > 0.999

 Male

250 (50.0%)

750 (50.0%)

 

 Female

250 (50.0%)

750 (50.0%)

 

BMI (kg/m2)

  

0.002

 Underweight (BMI < 18.5)

23 (4.6%)

24 (1.6%)

 

 Normal (18.0 ≤ BMI < 23.0)

173 (34.6%)

545 (36.3%)

 

 Overweight (23.0 ≤ BMI < 25.0)

135 (27.0%)

411 (27.4%)

 

 Obese (25.0 ≤ BMI)

169 (33.8%)

519 (34.6%)

 

 Unknown

0 (0%)

1 (0.1%)

 

Smoking history

  

0.226

 Never

339 (67.8%)

1092 (72.8%)

 

 Ever

161 (31.2%)

438 (29.2%)

 

Drinking history

  

0.394

 Never

265 (53.0%)

760 (50.7%)

 

 Ever

235 (47.0%)

740 (49.3%)

 
  1. BMI value was calculated using the following formula: weight in kilograms divided by the square of height in meter. Participants who had ever smoked or consumed alcohol were categorized as 'Ever'
  2. BMI body mass index, SD standard deviation
  3. aContinuous variables were analyzed using the linear rank test and categorical variables were analyzed using the log-rank test