Fig. 2

Manhattan plot of GWAS in the discovery study. Each dot represents the test results for a single SNP. The x-axis represents the genomic location along each chromosome, and the y-axis represents − log10 of the P-value. The solid horizontal line corresponds to a P-value of 5.00 × 10–8. Red dots represent SNPs with P-value < 5.00 × 10–8