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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: High Hcy regulates fluid shear stress pathway activity through histone H3K79 homocysteinylation in hyperhomocysteinemia-related child hypertension

Fig. 7

The schematic diagram illustrates the mechanism by which high Hcy levels promote hypertension. This occurs through the upregulation of H3K79hcy modifications, thereby epigenetically regulating the expression of TRX, GPX1, and related pathway factors such as NFkB to enhance oxidative stress, or by stimulating inflammation via the upregulation of ICAM1

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Journal of Translational Medicine

ISSN: 1479-5876

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