Fig. 3
From: The G-quadruplex ligand CX-5461: an innovative candidate for disease treatment
CX-5461 triggers TOP2-mediated DNA DSBs at transcription sites dependent on G4. In the model, the interaction of CX-5461 with G4 is facilitated by DNA topological stress provoked by RNA-Pol-dependent transcription that can be neutralized by TOP I; G4 stabilization by CX-5461 in transcription loci would give rise to unremitting RNA-Pol stasis, mobilizing TOP to settle the topological stress, and that TOP II may be poisoned at the transcribed region bearing G4