Fig. 4

Transcriptional analysis of DNAH-altered versus DNAH-unaltered primary tumors. A Volcano plot showing genes with a significantly different expression between DNAH-altered and DNAH-unaltered melanomas. B KEGG pathway enrichment analysis of genes identified through differential expression analysis in the discovery cohort. C Expression of immune-related gene signatures, comparing their levels between DNAH-altered and DNAH-unaltered melanomas. D Stacked bar plot of the mutation status of DNAH genes (DNAH2, DNAH6, DNAH9) in the TCGA pan-cancer cohort. E Differentially expressed genes between DNAH-altered (n = 143) and DNAH-unaltered (n = 799) cancers within the TCGA pan-cancer cohort. F Top 10 pathways corresponding to upregulated genes in the DNAH-altered and DNAH-unaltered cancers, as determined by KEGG analysis. Pathways upregulated in DNAH-unaltered cancers are reported with adjusted P-values (padj) for statistical significance after multiple testing corrections or nominal P-values (pval) for non-significance