Fig. 2

Genomic correlates of response to ICI treatment. A Mutational landscape of melanoma patients clustered by clinical response. B Comparison of mutational frequencies for the top frequently mutated features between responders (R) and non-responders (NR). The bar plot highlights genes with a ≥ 15% difference in mutational frequency between groups. C Copy number variant (CNV) analysis depicting the proportion of patients with focal-level CNV stratified by clinical response. D Prevalence of ten oncogenic signaling pathways in patients grouped by clinical response. E, F Functional annotation of genes with differential mutational frequencies between subgroups using KEGG (E) or GO analysis (F)