Table 1 Genetic associations with allergic disorders in sCCA and FOCUS analysis
Gene | CHR | Srart position | End position | Heritability Squared | TWAS Z | TWAS FDR P | FOCUS pip |
|---|---|---|---|---|---|---|---|
RP5-1115 A15.1 | 1 | 8,424,644 | 8,424,645 | 0.1611 | − 6.81478 | 1.2E-08 | 0.923 |
RERE | 1 | 8,817,642 | 8,817,643 | 0.3321 | − 6.61544 | 3.9E-08 | 0.997 |
RFTN2 | 2 | 197,676,044 | 197,676,045 | 0.1435 | 6.93279 | 7.2E-09 | 0.969 |
PLCL1 | 2 | 197,804,701 | 197,804,702 | 0.1789 | 6.757755 | 1.6E-08 | 0.837 |
IL1R2 | 2 | 101,991,843 | 101,991,844 | 0.4395 | 4.325578 | 1.8E-03 | 0.95 |
FARP2 | 2 | 241,356,242 | 241,356,243 | 0.3243 | 3.11431 | 5.0E-02 | 0.932 |
ATP1B3 | 3 | 141,876,123 | 141,876,124 | 0.0905 | − 4.92 | 2.0E-04 | 0.999 |
FAM114 A1 | 4 | 38,867,676 | 38,867,677 | 0.3223 | 11.1337 | 1.0E-24 | 1 |
KLF3 | 4 | 38,680,586 | 38,680,587 | 0.0735 | − 6.40443 | 1.3E-07 | 0.999 |
FAM114 A1 | 4 | 38,867,676 | 38,867,677 | 0.5296 | 5.56709 | 1.1E-05 | 1 |
FAM114 A1 | 4 | 38,867,676 | 38,867,677 | 0.3542 | 5.0457 | 1.2E-04 | 0.997 |
FAM114 A1 | 4 | 38,867,676 | 38,867,677 | 0.3542 | 5.0457 | 1.2E-04 | 0.971 |
RFC1 | 4 | 39,366,374 | 39,366,375 | 0.1071 | 4.52361 | 9.2E-04 | 0.997 |
RFC1 | 4 | 39,366,374 | 39,366,375 | 0.1071 | 4.52361 | 9.2E-04 | 1 |
SPATA5 | 4 | 122,923,073 | 122,923,074 | 0.2112 | 3.83259 | 8.5E-03 | 0.98 |
U91328.19 | 6 | 25,992,661 | 25,992,662 | 0.7309 | 5.824 | 3.0E-06 | 0.964 |
U91328.19 | 6 | 25,992,661 | 25,992,662 | 0.475 | − 5.64151 | 7.9E-06 | 0.998 |
ABT1 | 6 | 26,596,951 | 26,596,952 | 0.2157 | − 3.6894 | 1.3E-02 | 0.902 |
PVT1 | 8 | 127,794,532 | 127,794,533 | 0.2175 | 5.58441 | 1.0E-05 | 0.883 |
RANBP6 | 9 | 6,015,624 | 6,015,625 | 0.1052 | 4.31736 | 1.8E-03 | 0.956 |
KIAA2026 | 9 | 6,007,824 | 6,007,825 | 0.1628 | 4.26985 | 2.1E-03 | 0.984 |
TGFBR1 | 9 | 99,104,037 | 99,104,038 | 0.1129 | − 3.76475 | 1.0E-02 | 0.985 |
IL15RA | 10 | 5,978,186 | 5,978,187 | 0.3351 | 6.06753 | 8.8E-07 | 1 |
SUFU | 10 | 102,503,986 | 102,503,987 | 0.109 | 5.95708 | 1.5E-06 | 0.916 |
RBM17 | 10 | 6,088,986 | 6,088,987 | 0.2453 | 5.18371 | 6.9E-05 | 0.994 |
CUEDC2 | 10 | 102,432,660 | 102,432,661 | 0.0362 | − 4.91882 | 2.0E-04 | 0.874 |
RP11-563 J2.2 | 10 | 6,277,686 | 6,277,687 | 0.2516 | − 3.89475 | 7.0E-03 | 0.993 |
PRKCQ-AS1 | 10 | 6,580,418 | 6,580,419 | 0.1954 | 3.78693 | 9.8E-03 | 0.999 |
SIK2 | 11 | 111,602,390 | 111,602,391 | 0.1017 | 6.103014 | 7.2E-07 | 0.998 |
C11orf1 | 11 | 111,878,934 | 111,878,935 | 0.1407 | − 4.76819 | 3.7E-04 | 0.933 |
ELF1 | 13 | 41,061,272 | 41,061,273 | 0.0806 | − 5.17324 | 7.1E-05 | 0.983 |
CHP1 | 15 | 41,230,838 | 41,230,839 | 0.2169 | 5.69736 | 6.0E-06 | 0.95 |
TOM1L2 | 17 | 17,972,421 | 17,972,422 | 0.0527 | − 4.43104 | 1.2E-03 | 0.936 |
KRT15 | 17 | 41,522,528 | 41,522,529 | 0.3557 | − 4.138814 | 3.2E-03 | 0.834 |
CCDC116 | 22 | 21,632,715 | 21,632,716 | 0.4066 | − 4.66051 | 5.7E-04 | 0.945 |
LINC01637 | 22 | 20,957,091 | 20,957,092 | 0.2046 | − 3.639734 | 1.5E-02 | 0.823 |