Fig. 5

Manhattan Plot of Results from sCCA TWAS Analysis for Allergic Disorders. Manhattan plot of the TWAS P-values for allergic disorders. The x-axis represents chromosomes, and the y-axis shows the negative logarithm of the P-value (− log10(p)). The horizontal red line corresponds to a threshold of TWAS P = 1e-12 (A). Manhattan plot of the TWAS Z-scores for allergic disorders. The x-axis represents chromosomes, and the y-axis displays the Z-scores. The horizontal blue lines mark the absolute Z-score value of 7, which represents the threshold for significance (B)