Fig 4

Cell chat analysis results. A Results of cell chat analysis in normal lymph node tissue. B Results of cell chat analysis in plasma cell type CD tissue. C Results of cell chat analysis in mixed type CD tissue. D Results of cell chat analysis in hyaline vascular type CD tissue. E PRL signaling pathway in normal lymph node tissue. F IL-10 pathway in plasma cell type CD tissue. G BMP pathway in plasma cell type CD tissue. H VEGF pathway in plasma cell type CD tissue. I CD70 pathway in mixed type CD tissue. J CSF pathway in hyaline vascular type CD tissue. K Incoming signal patterns in mixed type CD tissue. L Difference in the CXCL signaling pathway in normal versus lesion tissues. The upper left figure demonstrates the CXCL pathway in normal lymph node tissue. The lower left panel shows the CXCL pathway in the diseased lymph node tissue (plasma cell type as an example). The diagram on the right reflects the receptors and ligands that play a major role in the CXCL pathway in diseased tissue (plasma cell type as an example).