Stage-dependent proteomic alterations in aqueous humor of diabetic retinopathy patients based on data-independent acquisition and parallel reaction monitoring

Table 1 The hub proteins (ranked by AUC) in NPDR vs. non-DR and PDR vs. NPDR

Protein	Gene name	Protein location	module	Ratio	P value	AUC value
NPDR vs. non-DR
P00734	F2	extracellular	turquoise	1.54009	0.036444	0.89
P03952	KLKB1	extracellular	turquoise	2.155632	0.010474	0.86
P02679	FGG	extracellular	turquoise	12.65522	0.033686	0.79
P02743	APCS	extracellular	turquoise	3.336828	0.035931	0.78
P02675	FGB	extracellular	turquoise	8.553475	0.044983	0.77
PDR vs. NPDR
P07357	C8A	extracellular	turquoise	2.222135	0.000302	0.94
P02753	RBP4	extracellular	turquoise	4.09654	0.000158	0.93
Q96IY4	CPB2	extracellular	turquoise	2.497397	0.001473	0.92
P04004	VTN	extracellular	turquoise	2.516913	0.007644	0.92
P02760	AMBP	extracellular	turquoise	3.088958	0.002747	0.91
P06681	C2	extracellular	turquoise	2.054174	0.006503	0.91
P00747	PLG	extracellular	turquoise	2.060559	0.000463	0.90
P43652	AFM	extracellular	turquoise	2.737774	0.004905	0.89
P13671	C6	extracellular	turquoise	2.938061	0.000725	0.89
P00734	F2	extracellular	turquoise	1.806203	0.002592	0.89

AUC, area under curve; non-DR, without diabetic retinopathy; NPDR, non-proliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy.

ISSN: 1479-5876