Fig. 4
PRM-based validation in an independent cohort. (A) ROC curves show the ability of the top five hub proteins (ranked by AUC) to distinguish NPDR from non-DR. (B) Lollipop diagram showing key pathways enriched for the seven DEPs from NPDR vs. non-DR. (C) PPI network of the five hub proteins from NPDR vs. non-DR. (D) ROC curves show the ability of the top ten hub proteins (ranked by AUC) to distinguish PDR from NPDR. (E) Lollipop diagram showing key pathways enriched for the 33 DEPs from PDR vs. NPDR. (F) PPI network of the 33 DEPs from PDR vs. NPDR. PRM: parallel reaction monitoring; ROC: receiver operating characteristic; AUC: area under curve; DEPs: differentially expressed proteins; PPI: protein-protein interaction; DR: diabetic retinopathy; NPDR: non proliferative diabetic retinopathy; PDR: proliferative diabetic retinopathy