Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets

Table 1 Clinical pathological characteristics and IHC markers of lung NET cohort

ID	SANET_002	SANET_004	SANET_005	SANET_006	SANET_011	SANET_016
Sex	F	F	M	F	M	M
Age	77	43	66	64	38	57
Histotype	TC	TC	TC	TC	TC	AC
Localization	cr	cr	Cl	pr	cr	cl
Ki-67(%)	1	1	0.5	1	1	3
MI (mm²)	1.5	1	1	0.5	0.5	3.5
Grade	G1	G1	G1	G1	G1	G2
Diameter (cm)	1.8	4.5	2.8	5	4.2	2.5
Stage	IA2	IIA	IIIB	IIB	IIA	IA3
CK AE1/AE3	+	+	+	+	+	+
CGA	+	+	+	+	+	−/+
SYN	+	+	+	+	+	+
INSM	+	+	+	+	+	+
TNM	pT1b pN0 LVI0	pT2b pN0 LVI0	pT4 pN2 LVI1	pT3 pNx LVI1	pT2b pN0 LVI1	pT1c pN0 LVI0
staging	PL0 R0	PL2 R1	PL2 R0	PL0 R0	PL0 R0	PL0 R0

TC = typical carcinoids; AC = atypical carcinoids; cr = central right; cl = central left; pr = peripheral right; MI = mitotic index; CK = Cytokeratin; CGA = Chromogranin A; SYN = Synaptophysin; INSM1 = Insulinoma-associated protein 1; TNM = Tumor– Nodes– Metastasis for IHC staining + = 100%; ± = 50–75%; −/ + = 25–50%; − = 0%

ISSN: 1479-5876