Fig. 1

Mutational profiling of samples derived from PBMC and FFPE. a PBMC-derived samples. The upper panel shows the transitions (Ti) and transversions (Tv) ratio, along with the distribution of single nucleotide variants (SNVs) for each sample. The lower panel displays the total number of mutations identified, categorized by variant classification, for each patient. b FFPE-derived samples. The upper panel shows the Ti/Tv ratio and SNV distribution for each sample. The lower panel displays the total number of mutations identified, categorized by variant classification, for each patient. FFPE-derived samples show a significantly higher number of mutations compared to PBMC-derived samples, with a predominance of variants classified as Missense Mutation and Frame Shift Del