Fig. 7
Cured mice displayed superior tumor growth control compared to naïve animals. (A) Representative scheme of rechallenge experiment. Cured mice are those animals that show complete tumor regression from combination therapy with 1959-sss/DM4 + anti-PD-1. (B) Tumor growth expressed as tumor volume (mm3) from rechallenge of NXS2 CTRL allografts in tumor naïve mice, cured mice treated with PBS, or cured mice treated with anti-PD-1. Arrows indicate administration of vehicle (PBS) or anti-PD-1 (10 mg/kg; twice weekly; three total i.p. injections). Two mice were considered per experimental group and curves reported refer to tumor growth of allografts of each single animal considered per group