Fig. 6

Biological features of adult T-ALL tumours expressing high levels of ABCB1. A: Results of the differential analysis between two groups of T-ALL patients with low expression of the gene ABCB1 (group “ABCB1-”, n = 67) and high expression of the gene ABCB1 (group “ABCB1+”, n = 66). The groups of low and high expression were identified with respect to the median expression level of ABCB1 in the total pooled adult T-ALL dataset. The volcano plot (left) and heatmap (right) were calculated similarly to Fig. 1B. The detailed results of the differential analysis are available in Supp. Table S2. B, C: Results of the GSEA analysis in the group “ABCB1+” versus the group “ABCB1-”. T-ALL tumours expressing high levels of ABCB1 are significantly depleted for gene expression involved in mitochondria function (B) and significantly enriched for gene expression involved in lipid droplet formation (C). The GSEA results were considered significant if the calculated p-values < 0.05 and false discovery rates (FDR) < 0.25