Fig. 5
From: Mitochondrial dysfunction fuels drug resistance in adult T-cell acute lymphoblastic leukemia
Lipogenic transcription factors LXR mediate the lipid-dependent activation of ABCB1 gene. A: Control (left panels) or Ethidium Bromide treated (200ng/mL and 100ng/mL, respectively, for 7 days) (right panels) CCRF-CEM and MOLT-4 cells (indicted), were treated with the indicated concentrations of LXR agonist, GW3965, for 24 h and the accumulation of P-gp and β-actin was visualized as above. B: The same experiment as above was carried out expect that cells were treated with LXR antagonist GSK2033, with the indicated concentration for 24 h