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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Treg and intestinal myofibroblasts-derived Amphiregulin induced by TGF-β mediates intestinal fibrosis in Crohn’s disease

Fig. 1

A single-cell atlas of full-thickness CD reveals higher numbers of Treg cells in stricturing Crohn’s disease. We got the scRNAseq data from Dr. Florian Rieder of Lerner Research Institute, Cleveland Clinic. Freshly resected full-thickness intestinal specimens, including strictured (CDs), nonstrictured (CDi), and noninvolved (CDni) tissues, were collected from CD patients. Both noninvolved and inflamed nonstrictured were classified as nonstrictured, and finally divided into two groups: stricture VS nonstricture. (A) Several types of cells were differentially expressed between stricture CD with nonstricture CD. (B) Different T cell ratios in stricture and nonstricture CD

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Journal of Translational Medicine

ISSN: 1479-5876

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