Fig. 2

Growth of murine MPM cells in DBA/2J-Gpnmb mutant mice. A Crossing of DBA/2J mice (GPNMB-deficient) and DBA/2J-GPNMB + mice (GPNMB-reconstituted) with BALB/c mice to generate a hybrid strain on a BALB/c background. BALB/c X DBA/2J strain (GPNMB KO) and the reconstituted strain BALB/c X DBA/2J-Gpnmb + (GPNMB WT) were used in the experiments. B Tumor progression (mean values of 5 mice) of AB1 cells in GPNMB KO mice (red lines) and in GPNMB WT mice (black lines), and C in each single mouse. Results are expressed as fold increase (F.I.) relative to the previous quantification. D Tumor progression (mean values of 5 mice) of AB22 cells in GPNMB KO mice (blue lines) and in GPNMB WT mice (black lines) and E in each single mouse. Statistical analysis Two-way ANOVA