Fig. 8
From: CXCL12/CXCR4 axis mediates CD8 + T cell overactivation in the progression of viral myocarditis
Blocking CXCR4 could alleviate myocardial inflammation and improve cardiac function. (A) Schematic workflow of blocking CXCR4. (B) Weight changes of mice in different groups during the experimental process. (C) Representative echocardiographic image of different groups. (D) Representative HE staining images in different groups. Scale bar, 20 μm. (E-F) The ejection fraction (E) and fraction shortening (F) change of three groups. (G) Tunel staining revealed the cell apoptosis in the myocardium of mice in different groups. Broken DNA were labeled with CF488 (green). Nuclei were stained with DAPI (blue). Scale bar, 50 μm. (H-I) The plasma expression level of cardiac troponin T(cTnT) (H) and TNF-α (I) in different group mice. Data are presented as mean ± SD (n = 5 biologically independent samples). *p < 0.05; **p < 0.01; ***p < 0.001 (Student’s t-test)