Fig. 7
From: CXCL12/CXCR4 axis mediates CD8 + T cell overactivation in the progression of viral myocarditis
CXCR4 blockade reduced CD8+T cell accumulation in the heart. (A) Immunofluorescence revealed the infiltration of CD8+T cells (red) in the myocardium among control group, MC group and CXCR4 blockade group. (B) The expression of CXCR4 in the heart of three groups tested by qRT-PCR. (C-G) The expression of cytotoxic genes GZMA(C), GZMB(D), Perforin(E), IFN-γ(F) and TNF-α(G) were significantly decreased in splenic CD8+T cells in CXCR4 blockade mice compared with that in MC mice tested by qRT-PCR. Unpaired t-test was used for analysis. Data are presented as mean ± SD (n = 3–5 biologically independent samples). *p < 0.05; **p < 0.01; ***p < 0.001