Fig. 3

Cell–cell interactions. The heat map shows the number (A) and intensity (B) of interactions between cells. The vertical axis represents cells that send signals, and the horizontal axis represents cells that receive signals. The darker the color, the stronger the intensity. The heat map shows the pathways involved in cell incoming signals (C) and outgoing signals (D). The horizontal axis represents the cell type, and the vertical axis represents the signal pathway. The darker the color, the stronger the intensity of the incoming (outgoing) pathway. E Ligand-receptor pairs of epithelial cells to CAFs (efferent signals from epithelial cells, incoming signals from CAFs). F Ligand-receptor pairs from CAFs subpopulations to epithelial cells (efferent signals from CAFs, incoming signals from epithelial cells) cell incoming signal)