Fig. 2

Subclustering and annotation of fibroblasts. A UMAP diagram shows the origin of fibroblasts. B Cell grouping results of fibroblast subpopulations. C Annotation results of fibroblast subpopulation cells. D The proportion of fibroblast subpopulation cells in each sample. E The expression of marker genes in each subpopulation of fibroblasts. F Heatmap showing pathway activity scored by AUCell in each CAF subtype. G Scatter plot showing the regulon specificity score (RSS) of transcription factors in each fibroblast subtype, with the top five transcription factors highlighted. H Trajectory analysis results for each CAF subtype