Fig. 2

High IgG levels and absence of systemic inflammation during ASY malaria. Plasma samples were used in a bead fluorometric assay measurement of 27 serum cytokines, chemokines, and growth factors. (A) Statistical summary of all soluble factors relative to each group. Data was scaled using z-scores. Dot represents the median, and vertical lines represent the interquartile range for each group represented by colors: symptomatic (SY, turquoise, n = 28), asymptomatic (ASY, salmon, n = 41), and healthy controls (CTL, gray, n = 21). Asterisks represent differences compared to CTL. (B) Levels of IgG against PvMSP1₁₉, PvAMA1₆₆, and PvDBPII_brz−2 (B) and IgG subclasses against PvMSP1₁₉ and PvAMA1₆₆ (C) by group. Gray lines represent the reactivity index cut-off. Dunns’ test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001